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ChEMBL ligand: CHEMBL293492 (Abion ca, .beta.-phenylacrolein, Cinnamal, Cinnamaldehyde, Cinnamic aldehyde, FEMA NO. 2286, NSC-16935, NSC-40346, XC-800, Zimtaldehyde) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
ChEMBL | Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC method | B | 4.46 | pIC50 | 35000 | nM | IC50 | Bioorg Med Chem (2019) 27: 3745-3759 [PMID:31331653] |
Cell division protein ftsZ in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6] | ||||||||
ChEMBL | Inhibition of Escherichia coli FtsZ polymerization | B | 5.16 | pIC50 | 6860 | nM | IC50 | Eur J Med Chem (2015) 95: 1-15 [PMID:25791674] |
ChEMBL | Inhibition of Escherichia coli FtsZ GTPase activity | B | 5.24 | pIC50 | 5810 | nM | IC50 | Eur J Med Chem (2015) 95: 1-15 [PMID:25791674] |
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count | F | 4.29 | pEC50 | 51400 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 276-279 [PMID:19945872] |
ChEMBL | Activation of TRPA1 | B | 4.72 | pEC50 | 19000 | nM | EC50 | Nature (2007) 445: 541-545 [PMID:17237762] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 5.05 | pEC50 | 9000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 5.07 | pEC50 | 8511.38 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels | B | 5.19 | pEC50 | 6500 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8] | ||||||||
GtoPdb | - | - | 4.2 | pEC50 | 63000 | nM | EC50 | Neuron (2004) 41: 849-57 [PMID:15046718] |
ChEMBL | Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis | B | 4.21 | pEC50 | 61000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]