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ChEMBL ligand: CHEMBL2386188 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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TRPV6/Transient receptor potential cation channel subfamily V member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628465] [GtoPdb: 512] [UniProtKB: Q9H1D0] | ||||||||
ChEMBL | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay | B | 4.72 | pIC50 | 19200 | nM | IC50 | Bioorg Med Chem (2013) 21: 3202-3213 [PMID:23602525] |
ChEMBL | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay | B | 4.75 | pIC50 | 17700 | nM | IC50 | Bioorg Med Chem (2013) 21: 3202-3213 [PMID:23602525] |
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] | ||||||||
GtoPdb | Patch clamp electrophysiology | - | 4.2 | pEC50 | 63095 | nM | EC50 | J Biol Chem (2005) 280: 15928-41 [PMID:15722340] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]