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ChEMBL ligand: CHEMBL120526 (Methanandamide, (R)-Methanandamide) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assay | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 7.55 | pKi | 28.3 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
ChEMBL | Tested for binding affinity to Cannabinoid receptor 1 | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1999) 42: 896-902 [PMID:10072686] |
ChEMBL | Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranes | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1996) 39: 4515-4519 [PMID:8893848] |
ChEMBL | Displacement of [3H]-CP55940 from CB1 receptor of rat cerebellar membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
GtoPdb | - | - | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1996) 39: 4515-9 [PMID:8893848] |
ChEMBL | Displacement of [3H]CP-55940 from cannabinoid CB1 receptor in rat brain membrane in presence of phenylmethanesulfonyl fluoride | B | 7.75 | pKi | 17.9 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 5912-5915 [PMID:18723350] |
ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 7.75 | pKi | 17.9 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
ChEMBL | Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
ChEMBL | Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
ChEMBL | Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]CP-55940 as radioligand | B | 6.06 | pKi | 868 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
ChEMBL | Displacement of [3H]CP-55940 from cannabinoid CB2 receptor in mouse spleen membrane | B | 6.06 | pKi | 868 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 5912-5915 [PMID:18723350] |
ChEMBL | Compound was evaluated for its binding affinity for mouse spleen Cannabinoid receptor 2 | B | 6.09 | pKi | 815 | nM | Ki | J Med Chem (1996) 39: 4515-4519 [PMID:8893848] |
ChEMBL | Binding affinity to mouse spleen CB2 receptor | B | 6.09 | pKi | 815 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
K2P3.1/Potassium channel subfamily K member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649] | ||||||||
GtoPdb | - | - | 6.15 | pIC50 | ~700 | nM | IC50 | EMBO J (2001) 20: 47-54 [PMID:11226154] |
ChEMBL | Inhibition of human TASK1 expressed in African green monkey COS cells by whole cell patch clamp assay | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]