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ChEMBL ligand: CHEMBL479014 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
GtoPdb | - | - | 6.5 | pIC50 | 316 | nM | IC50 | Life Sci (1995) 57: PL131-5 [PMID:7544863] |
ChEMBL | Inhibition of NOS1 | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem (2009) 17: 6180-6187 [PMID:19679481] |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | Inhibition of rat brain recombinant nNOS | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134] |
Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
ChEMBL | Inhibition of bovine recombinant eNOS | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
ChEMBL | Inhibition of NOS2 | B | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem (2009) 17: 6180-6187 [PMID:19679481] |
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
ChEMBL | Inhibition of mouse recombinant iNOS | B | 5.66 | pIC50 | 2200 | nM | IC50 | Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]