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ChEMBL ligand: CHEMBL119385 (745, Neflamapimod, VD-31, VD-31,745, VD-31745, VRT-031745, Vx-745, VX-745) |
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530] | ||||||||
ChEMBL | Binding constant for full-length PDPK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PDPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
ChEMBL | Binding constant for ACVR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ACVR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] | ||||||||
ChEMBL | Binding constant for ACVR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ACVR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037] | ||||||||
ChEMBL | Binding constant for ACVR2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ACVR2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705] | ||||||||
ChEMBL | Binding constant for ACVR2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ACVR2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
AP2 associated kinase 1/Adaptor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8] | ||||||||
ChEMBL | Binding constant for AAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) | B | 5.32 | pKi | 4831 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) | B | 5.07 | pIC50 | 8547 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Binding constant for ALK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ALK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 4.89 | pKi | 12813 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 4.47 | pIC50 | 34167 | nM | IC50 | DrugMatrix in vitro pharmacology data |
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
ChEMBL | DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) | B | 4.84 | pKi | 14557 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) | B | 4.5 | pIC50 | 31886 | nM | IC50 | DrugMatrix in vitro pharmacology data |
protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131] | ||||||||
ChEMBL | Binding constant for AMPK-alpha1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AMPK-alpha1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646] | ||||||||
ChEMBL | Binding constant for AMPK-alpha2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AMPK-alpha2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2] | ||||||||
ChEMBL | Binding constant for ANKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ANKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1] | ||||||||
ChEMBL | Binding constant for BIKE kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BIKE kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
ChEMBL | Binding constant for BMPR1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BMPR1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
ChEMBL | Binding constant for BMPR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
ChEMBL | Binding constant for BMPR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BMPR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3] | ||||||||
ChEMBL | Binding constant for BRSK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BRSK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3] | ||||||||
ChEMBL | Binding constant for full-length BRSK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BRSK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Calcium-dependent protein kinase 1 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908387] [UniProtKB: P62344] | ||||||||
ChEMBL | Binding constant for PFCDPK1(P.falciparum) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012] | ||||||||
ChEMBL | Binding constant for full-length CAMK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] | ||||||||
ChEMBL | Binding constant for CAMK1D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK1D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5] | ||||||||
ChEMBL | Binding constant for CAMK1G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK1G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] | ||||||||
ChEMBL | Binding constant for CAMK2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554] | ||||||||
ChEMBL | Binding constant for CAMK2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
ChEMBL | Binding constant for CAMK2D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK2D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555] | ||||||||
ChEMBL | Binding constant for CAMK2G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK2G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
ChEMBL | Binding constant for CAMK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9] | ||||||||
ChEMBL | Binding constant for CAMKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4] | ||||||||
ChEMBL | Binding constant for CAMKK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CAMKK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Binding constant for PKAC-alpha kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PKAC-alpha kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694] | ||||||||
ChEMBL | Binding constant for full-length PKAC-beta | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PKAC-beta kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
ChEMBL | Binding constant for CSNK1A1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
ChEMBL | Binding constant for full-length CSNK1D | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK1D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
ChEMBL | Binding constant for full-length CSNK1E | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK1E kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] | ||||||||
ChEMBL | Binding constant for CSNK1G1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK1G1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368] | ||||||||
ChEMBL | Binding constant for full-length CSNK1G2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK1G2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
ChEMBL | Binding constant for full-length CSNK2A1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK2A1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784] | ||||||||
ChEMBL | Binding constant for full-length CSNK2A2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK2A2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752] | ||||||||
ChEMBL | Binding constant for full-length CSNK1A1L | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK1A1L kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4] | ||||||||
ChEMBL | Binding constant for full-length CSNK1G3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSNK1G3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Cell division control protein 2 homolog in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908388] [UniProtKB: P61075] | ||||||||
ChEMBL | Binding constant for PFPK5(P.falciparum) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
ChEMBL | Binding constant for CDK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336] | ||||||||
ChEMBL | Binding constant for CDK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976] | ||||||||
ChEMBL | Binding constant for PRKG1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKG1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237] | ||||||||
ChEMBL | Binding constant for PRKG2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKG2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60] | ||||||||
ChEMBL | Binding constant for ADCK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ADCK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578] | ||||||||
ChEMBL | Binding constant for CIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Binding constant for full-length JNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for JNK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Binding constant for full-length JNK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for JNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
ChEMBL | Binding constant for JNK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for JNK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of JNK3 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004] | ||||||||
ChEMBL | Binding constant for CDC2L5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Binding constant for full-length CDK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of CDK2 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526] | ||||||||
ChEMBL | Binding constant for full-length CDK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
ChEMBL | Binding constant for CDK4-cyclinD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for CDK4-cyclinD3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Binding constant for full-length CDK5 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
ChEMBL | Binding constant for full-length CDK7 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
ChEMBL | Binding constant for full-length CDK9 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532] | ||||||||
ChEMBL | Binding constant for CDKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772] | ||||||||
ChEMBL | Binding constant for CDKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4] | ||||||||
ChEMBL | Binding constant for CDKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039] | ||||||||
ChEMBL | Binding constant for CDKL5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355] | ||||||||
ChEMBL | Binding constant for DAPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DAPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4] | ||||||||
ChEMBL | Binding constant for full-length DAPK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DAPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
ChEMBL | Binding constant for full-length DLK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DAPK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DAPK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832] | ||||||||
ChEMBL | Binding constant for DDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
ChEMBL | DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) | B | 5.19 | pKi | 6434 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) | B | 5.09 | pIC50 | 8098 | nM | IC50 | DrugMatrix in vitro pharmacology data |
dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3] | ||||||||
ChEMBL | Binding constant for RIPK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
ChEMBL | Binding constant for full-length MEK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] | ||||||||
ChEMBL | Binding constant for full-length MEK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734] | ||||||||
ChEMBL | Binding constant for full-length MEK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MEK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
ChEMBL | Binding constant for MEK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MEK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163] | ||||||||
ChEMBL | Binding constant for MEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564] | ||||||||
ChEMBL | Binding constant for MEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] | ||||||||
ChEMBL | Binding constant for MKK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
ChEMBL | Binding constant for CLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
ChEMBL | Binding constant for full-length CLK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
ChEMBL | Binding constant for CLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
ChEMBL | Binding constant for TTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] | ||||||||
ChEMBL | Binding constant for TESK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TESK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
ChEMBL | Binding constant for DYRK1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
ChEMBL | Binding constant for full-length DYRK1B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DYRK1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
ChEMBL | Binding constant for DYRK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Binding constant for full-length CLK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] | ||||||||
ChEMBL | Binding constant for EPHA1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA1 kinase domain | B | 5.33 | pKd | 4700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
ChEMBL | Binding constant for EPHA2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for EPHA2; NA=Not Active at 10 uM | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
ChEMBL | Binding constant for EPHA3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
ChEMBL | Average Binding Constant for EPHA4; NA=Not Active at 10 uM | B | 5 | pKd | 10000 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for EPHA4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] | ||||||||
ChEMBL | Binding constant for EPHA5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for EPHA5; NA=Not Active at 10 uM | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33] | ||||||||
ChEMBL | Binding constant for EPHA6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] | ||||||||
ChEMBL | Binding constant for EPHA7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] | ||||||||
ChEMBL | Binding constant for EPHA8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHA8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for EPHA8; NA=Not Active at 10 uM | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
ChEMBL | Binding constant for EPHB1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHB1 kinase domain | B | 5.21 | pKd | 6200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for EPHB1; NA=Not Active at 10 uM | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
ChEMBL | Binding constant for EPHB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] | ||||||||
ChEMBL | Binding constant for EPHB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
ChEMBL | Binding constant for EPHB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EPHB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for EPHB4; NA=Not Active at 10 uM | B | 6 | pKd | 1000 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197] | ||||||||
ChEMBL | Binding constant for EPHB6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Binding constant for EGFR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(E746-A750del) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(G719C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(G719S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(L747-E749del, A750P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(L747-S752del, P753S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(L747-T751del,Sins) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(L858R) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(L861Q) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR(S752-I759del) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for EGFR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(E746-A750del) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(G719C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(G719S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(L747-E749del, A750P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(L747-S752del, P753S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(L747-T751del,Sins) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(L858R) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(L858R,T790M) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(L861Q) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(S752-I759del) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for EGFR(T790M) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
ChEMBL | Binding constant for DDR1 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DDR1 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3] | ||||||||
ChEMBL | Binding constant for EIF2AK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8] | ||||||||
ChEMBL | Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Binding constant for FGFR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FGFR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
ChEMBL | Binding constant for FGFR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FGFR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
ChEMBL | Binding constant for FGFR3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FGFR3(G697C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FGFR3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FGFR3(G697C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
ChEMBL | Binding constant for FGFR4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FGFR4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Binding constant for PTK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Binding constant for full-length GSK3A | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for GSK3A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Binding constant for full-length GSK3B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for GSK3B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
G protein-coupled receptor kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298] | ||||||||
ChEMBL | Binding constant for GRK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
G protein-coupled receptor kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075133] [GtoPdb: 1471] [UniProtKB: Q8WTQ7] | ||||||||
ChEMBL | Binding constant for GRK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Binding constant for MET kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MET kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for MET(M1250T) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for MET(Y1235D) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02] | ||||||||
ChEMBL | Binding constant for HIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] | ||||||||
ChEMBL | Binding constant for HIPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422] | ||||||||
ChEMBL | Binding constant for HIPK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63] | ||||||||
ChEMBL | Binding constant for HIPK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058] | ||||||||
ChEMBL | Binding constant for HUNK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
ChEMBL | Binding constant for IKK-alpha kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Binding constant for IKK-beta kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Binding constant for full-length IKK-epsilon | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for IKK-epsilon kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Binding constant for IGF1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for IGF1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of IGF1R by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Binding constant for INSR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for INSR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616] | ||||||||
ChEMBL | Binding constant for INSRR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for INSRR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
ChEMBL | Binding constant for PRKR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
ChEMBL | Binding constant for IRAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616] | ||||||||
ChEMBL | Binding constant for IRAK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for IRAK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
ChEMBL | Binding constant for IRAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] | ||||||||
ChEMBL | Binding constant for LRRK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for LRRK2(G2019S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376] | ||||||||
ChEMBL | Binding constant for LTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
ChEMBL | Binding constant for full-length LIMK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LIMK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
ChEMBL | Binding constant for full-length LIMK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LIMK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
ChEMBL | Binding constant for CSF1R kinase domain | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSF1R kinase domain | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
ChEMBL | Binding constant for MST1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Binding constant for MAPKAPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MAPKAPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of MK2 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
ChEMBL | Binding constant for MAPKAPK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MAPKAPK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Binding constant for full-length ERK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Binding constant for full-length ERK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of Erk2 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Binding constant for full-length MKNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MKNK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Average Binding Constant for p38-alpha; NA=Not Active at 10 uM | B | 8.49 | pKd | 3.2 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for full-length p38-alpha | B | 8.55 | pKd | 2.8 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for p38-alpha kinase domain | B | 8.55 | pKd | 2.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding affinity to p38alpha (unknown origin) | B | 8.55 | pKd | 2.8 | nM | Kd | J Med Chem (2013) 56: 2619-2629 [PMID:23442188] |
ChEMBL | Inhibition of MAPK14 (unknown origin) | B | 4.6 | pIC50 | 25118.86 | nM | IC50 | J Med Chem (2013) 56: 6991-7002 [PMID:23937569] |
ChEMBL | Inhibition of human p38-alpha kinase phosphorylation | B | 5.28 | pIC50 | 5300 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1772-1777 [PMID:18325768] |
ChEMBL | DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) | B | 6.19 | pIC50 | 643 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Inhibition of p38alpha in human whole blood assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA | B | 6.74 | pIC50 | 180 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
ChEMBL | Inhibition of p38alpha in human whole blood assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA | B | 6.82 | pIC50 | 150 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
ChEMBL | Inhibition of p38alpha | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5851-5856 [PMID:19751974] |
ChEMBL | Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA | B | 7.29 | pIC50 | 51 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
ChEMBL | Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA | B | 7.35 | pIC50 | 45 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
ChEMBL | In vitro inhibitory activity determined against human mitogen-activated protein kinase p38 alpha | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2003) 46: 5651-5662 [PMID:14667219] |
ChEMBL | Inhibition of human p38-alpha kinase | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1772-1777 [PMID:18325768] |
GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Nat Biotechnol (2008) 26: 127-32 [PMID:18183025] |
ChEMBL | Inhibition of human recombinant p38alpha by liquid scintillation counting | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Antagonist activity at p38 MAPK alpha (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2022) 65: 1225-1242 [PMID:33974419] |
ChEMBL | Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay | B | 8.05 | pIC50 | 9 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2336] [GtoPdb: 1499] [UniProtKB: P47811] | ||||||||
ChEMBL | Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcription factor-2). | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2003) 46: 349-352 [PMID:12540232] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
ChEMBL | Average Binding Constant for p38-beta; NA=Not Active at 10 uM | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for full-length p38-beta | B | 7.13 | pKd | 74 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for p38-beta kinase domain | B | 7.13 | pKd | 74 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of p38beta using KRELVEPLTPSGEAPNQALLR as substrate for 10 mins by lactate dehydrogenase-coupled spectrophotometric assay | B | 6.66 | pKi | 220 | nM | Ki | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
ChEMBL | Inhibition of human p38beta | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2019) 62: 5298-5311 [PMID:30978288] |
GtoPdb | - | - | 6.66 | pIC50 | 220 | nM | IC50 | Nat Biotechnol (2008) 26: 127-32 [PMID:18183025] |
mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
ChEMBL | Binding constant for p38-delta kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
ChEMBL | Binding constant for full-length p38-gamma | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for p38-gamma kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding affinity to p38gamma (unknown origin) | B | 5 | pKd | >10000 | nM | Kd | J Med Chem (2013) 56: 2619-2629 [PMID:23442188] |
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
ChEMBL | Binding constant for MKNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MKNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
ChEMBL | Binding constant for MARK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MARK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34] | ||||||||
ChEMBL | Binding constant for MARK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MARK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680] | ||||||||
ChEMBL | Binding constant for full-length MELK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MELK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9] | ||||||||
ChEMBL | Binding constant for MAST1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8] | ||||||||
ChEMBL | Binding constant for MINK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08] | ||||||||
ChEMBL | Binding constant for ERK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152] | ||||||||
ChEMBL | Binding constant for ERK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659] | ||||||||
ChEMBL | Binding constant for ERK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164] | ||||||||
ChEMBL | Binding constant for ERK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
ChEMBL | Binding constant for MAP3K1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] | ||||||||
ChEMBL | Binding constant for MLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
ChEMBL | Binding constant for MLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852] | ||||||||
ChEMBL | Binding constant for DLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283] | ||||||||
ChEMBL | Binding constant for LZK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16] | ||||||||
ChEMBL | Binding constant for MAP3K15 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5] | ||||||||
ChEMBL | Binding constant for MAP3K2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759] | ||||||||
ChEMBL | Binding constant for MAP3K3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4] | ||||||||
ChEMBL | Binding constant for MAP3K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MAP3K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683] | ||||||||
ChEMBL | Binding constant for MAP3K5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ASK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382] | ||||||||
ChEMBL | Binding constant for ASK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
ChEMBL | Binding constant for TAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
ChEMBL | Binding constant for MLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918] | ||||||||
ChEMBL | Binding constant for MAP4K1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for HPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851] | ||||||||
ChEMBL | Binding constant for MAP4K2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8] | ||||||||
ChEMBL | Binding constant for MAP4K3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MAP4K3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
ChEMBL | Binding constant for MAP4K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MAP4K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4] | ||||||||
ChEMBL | Binding constant for MAP4K5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MAP4K5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
ChEMBL | Binding constant for ZAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ZAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] | ||||||||
ChEMBL | Binding constant for MUSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MUSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
myosin IIIA/Myosin IIIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4] | ||||||||
ChEMBL | Binding constant for MYO3A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MYO3A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
myosin IIIB/Myosin-IIIB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4] | ||||||||
ChEMBL | Binding constant for MYO3B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MYO3B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
myosin light chain kinase 3/Myosin light chain kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0] | ||||||||
ChEMBL | Binding constant for MLCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3] | ||||||||
ChEMBL | Binding constant for MYLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MYLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6] | ||||||||
ChEMBL | Binding constant for SgK085 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MYLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799] | ||||||||
ChEMBL | Binding constant for MLCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746] | ||||||||
ChEMBL | Binding constant for MYLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MYLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013] | ||||||||
ChEMBL | Binding constant for DMPK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DMPK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Binding constant for TRKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TRKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
ChEMBL | Binding constant for TRKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TRKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470] | ||||||||
ChEMBL | Binding constant for full-length TNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TNK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) | B | 4.69 | pKi | 20236 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) | B | 4.69 | pIC50 | 20404 | nM | IC50 | DrugMatrix in vitro pharmacology data |
neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
ChEMBL | Binding constant for TRKC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TRKC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285] | ||||||||
ChEMBL | Binding constant for ARK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ARK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093] | ||||||||
ChEMBL | Binding constant for SNARK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SNARK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936] | ||||||||
ChEMBL | Binding constant for CASK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750] | ||||||||
ChEMBL | Binding constant for PIK3C2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747] | ||||||||
ChEMBL | Binding constant for PIK3C2G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755] | ||||||||
ChEMBL | Binding constant for full-length PIP5K1A | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIP5K1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331] | ||||||||
ChEMBL | Binding constant for PIP5K1C kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356] | ||||||||
ChEMBL | Binding constant for full-length PIP5K2B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIP5K2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8] | ||||||||
ChEMBL | Binding constant for PIP5K2C kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816] | ||||||||
ChEMBL | Binding constant for full-length PHKG1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PHKG1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735] | ||||||||
ChEMBL | Binding constant for PHKG2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PHKG2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
ChEMBL | Binding constant for PIK3CA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIK3CA(E545K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIK3CA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(C420R) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(E542K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(E545A) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(E545K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(H1047L) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(H1047Y) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(I800L) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(M1043I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for PIK3CA(Q546K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
ChEMBL | Binding constant for PIK3CB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
ChEMBL | Binding constant for PIK3CD kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
ChEMBL | Binding constant for PIK3CG kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
phosphatidylinositol 4-kinase beta/PI4-kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8] | ||||||||
ChEMBL | Binding constant for PIK4CB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127] | ||||||||
ChEMBL | Binding constant for CDC2L1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDC2L1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88] | ||||||||
ChEMBL | Binding constant for CDC2L2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CDC2L2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
ChEMBL | Binding constant for PDGFRA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PDGFRA kinase domain | B | 5.06 | pKd | 8800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
ChEMBL | Binding constant for PDGFRB kinase domain | B | 5.08 | pKd | 8400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PDGFRB kinase domain | B | 5.08 | pKd | 8400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for PDGFRB; NA=Not Active at 10 uM | B | 6.06 | pKd | 870 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Inhibition of human PRGFRbeta | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2019) 62: 5298-5311 [PMID:30978288] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
ChEMBL | Binding constant for PRKCD kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKCD kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
ChEMBL | Binding constant for PRKCE kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKCE kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
ChEMBL | Binding constant for PRKCH kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKCH kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743] | ||||||||
ChEMBL | Binding constant for PRKCI kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
ChEMBL | Binding constant for PRKD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
ChEMBL | Binding constant for PRKD3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKD3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] | ||||||||
ChEMBL | Binding constant for PRKCQ kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKCQ kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase N1/Protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512] | ||||||||
ChEMBL | Binding constant for PKN1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PKN1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513] | ||||||||
ChEMBL | Binding constant for PKN2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PKN2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
ChEMBL | Binding constant for full-length PTK2B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PYK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
ChEMBL | Binding constant for MERTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MERTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
ChEMBL | Binding constant for ROS1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ROS1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
sugen kinase 110/Putative uncharacterized serine/threonine-protein kinase SgK110 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264] | ||||||||
ChEMBL | Binding constant for SgK110 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
ChEMBL | Binding constant for RIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078] | ||||||||
ChEMBL | Binding constant for RIPK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Binding constant for ERBB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ERBB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
ChEMBL | Binding constant for ERBB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860] | ||||||||
ChEMBL | Binding constant for ERBB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
ChEMBL | Binding constant for ROCK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of ROCK1 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
ChEMBL | Binding constant for ROCK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
G protein-coupled receptor kinase 1/Rhodopsin kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835] | ||||||||
ChEMBL | Binding constant for GRK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
ChEMBL | Binding constant for S6K1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] | ||||||||
ChEMBL | Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349] | ||||||||
ChEMBL | Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA2(Kin.Dom.2 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
ChEMBL | Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
ChEMBL | Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA4(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
ChEMBL | Binding constant for RPS6KA5(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA5(Kin.Dom.1 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32] | ||||||||
ChEMBL | Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804] | ||||||||
ChEMBL | Binding constant for LOK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LOK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831] | ||||||||
ChEMBL | Binding constant for full-length LKB1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LKB1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716] | ||||||||
ChEMBL | Binding constant for STK16 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for STK16 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5] | ||||||||
ChEMBL | Binding constant for DRAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DRAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768] | ||||||||
ChEMBL | Binding constant for full-length DRAK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DRAK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2] | ||||||||
ChEMBL | Binding constant for SLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0] | ||||||||
ChEMBL | Binding constant for MST3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MST3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506] | ||||||||
ChEMBL | Binding constant for YSK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for YSK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08] | ||||||||
ChEMBL | Binding constant for YANK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57] | ||||||||
ChEMBL | Binding constant for full-length YANK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for YANK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6] | ||||||||
ChEMBL | Binding constant for YANK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for YANK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3] | ||||||||
ChEMBL | Binding constant for full-length STK33 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for STK33 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2] | ||||||||
ChEMBL | Binding constant for STK35 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7] | ||||||||
ChEMBL | Binding constant for STK36 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for STK36 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208] | ||||||||
ChEMBL | Binding constant for NDR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1] | ||||||||
ChEMBL | Binding constant for NDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Binding constant for AKT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AKT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
ChEMBL | Binding constant for AKT2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AKT2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
ChEMBL | Binding constant for AKT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AKT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of Akt3 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Binding constant for AURKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AURKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Binding constant for AURKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AURKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9] | ||||||||
ChEMBL | Binding constant for full-length AURKC | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AURKC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
ChEMBL | Binding constant for BRAF kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BRAF(V600E) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BRAF kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for BRAF(V600E) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Binding constant for CHEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CHEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
ChEMBL | Binding constant for CHEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
ChEMBL | Binding constant for full-length MARK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MARK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
ChEMBL | Binding constant for PRKD2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKD2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075] | ||||||||
ChEMBL | Binding constant for DCAMKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DCAMKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568] | ||||||||
ChEMBL | Binding constant for DCAMKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DCAMKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098] | ||||||||
ChEMBL | Binding constant for DCAMKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DCAMKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460] | ||||||||
ChEMBL | Binding constant for ERN1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976] | ||||||||
ChEMBL | Binding constant for GAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for GAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9] | ||||||||
ChEMBL | Binding constant for ICK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835] | ||||||||
ChEMBL | Binding constant for LATS1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LATS1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7] | ||||||||
ChEMBL | Binding constant for LATS2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LATS2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794] | ||||||||
ChEMBL | Binding constant for MAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2] | ||||||||
ChEMBL | Binding constant for MARK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MARK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] | ||||||||
ChEMBL | Binding constant for MRCKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MRCKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2] | ||||||||
ChEMBL | Binding constant for MRCKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MRCKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37] | ||||||||
ChEMBL | Binding constant for DMPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for DMPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043] | ||||||||
ChEMBL | Binding constant for full-length MST1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MST1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
ChEMBL | Binding constant for MST2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MST2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
ChEMBL | Binding constant for full-length MST4 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for MST4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
ChEMBL | Binding constant for MTOR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6] | ||||||||
ChEMBL | Binding constant for NEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66] | ||||||||
ChEMBL | Binding constant for NEK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
ChEMBL | Binding constant for NEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956] | ||||||||
ChEMBL | Binding constant for NEK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957] | ||||||||
ChEMBL | Binding constant for NEK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8] | ||||||||
ChEMBL | Binding constant for NEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
ChEMBL | Binding constant for NEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7] | ||||||||
ChEMBL | Binding constant for full-length NEK7 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NEK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19] | ||||||||
ChEMBL | Binding constant for NEK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NEK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
ChEMBL | Binding constant for NIM1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8] | ||||||||
ChEMBL | Binding constant for full-length NLK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for NLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747] | ||||||||
ChEMBL | Binding constant for OSR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
ChEMBL | Binding constant for PAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177] | ||||||||
ChEMBL | Binding constant for PAK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PAK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914] | ||||||||
ChEMBL | Binding constant for full-length PAK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PAK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Binding constant for PAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5] | ||||||||
ChEMBL | Binding constant for PAK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PAK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286] | ||||||||
ChEMBL | Binding constant for PAK7/PAK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PAK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536] | ||||||||
ChEMBL | Binding constant for PCTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PCTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537] | ||||||||
ChEMBL | Binding constant for full-length PCTK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PCTK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002] | ||||||||
ChEMBL | Binding constant for full-length PCTK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PCTK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921] | ||||||||
ChEMBL | Binding constant for full-length PFTK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PFTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
cyclin dependent kinase 15/Serine/threonine-protein kinase PFTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40] | ||||||||
ChEMBL | Binding constant for PFTAIRE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Binding constant for PIM1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIM1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of PIM1 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
ChEMBL | Binding constant for PIM2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIM2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
ChEMBL | Binding constant for PIM3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PIM3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Serine/threonine-protein kinase pknB in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81] | ||||||||
ChEMBL | Binding constant for PKNB(M.tuberculosis) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Binding constant for PLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3] | ||||||||
ChEMBL | Binding constant for PLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
ChEMBL | Binding constant for PLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] | ||||||||
ChEMBL | Binding constant for PLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817] | ||||||||
ChEMBL | Binding constant for full-length PRKX | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PRKX kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523] | ||||||||
ChEMBL | Binding constant for PRP4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
ChEMBL | Binding constant for RAF1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RAF1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
ChEMBL | Binding constant for ACVRL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ACVRL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2] | ||||||||
ChEMBL | Binding constant for full-length RIOK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RIOK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4] | ||||||||
ChEMBL | Binding constant for RIOK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730] | ||||||||
ChEMBL | Binding constant for full-length RIOK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RIOK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] | ||||||||
ChEMBL | Binding constant for RIPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RIPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2] | ||||||||
ChEMBL | Binding constant for SBK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1] | ||||||||
ChEMBL | Binding constant for SGK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059] | ||||||||
ChEMBL | Binding constant for SNF1LK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SIK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1] | ||||||||
ChEMBL | Binding constant for full-length SNF1LK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SIK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2] | ||||||||
ChEMBL | Binding constant for QSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4] | ||||||||
ChEMBL | Binding constant for full-length SRPK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SRPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362] | ||||||||
ChEMBL | Binding constant for full-length SRPK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SRPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1] | ||||||||
ChEMBL | Binding constant for SRPK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
ChEMBL | Binding constant for TAOK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54] | ||||||||
ChEMBL | Binding constant for TAOK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
ChEMBL | Binding constant for TAOK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
ChEMBL | Binding constant for TBK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18] | ||||||||
ChEMBL | Binding constant for full-length TNNI3K | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TNNI3K kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8] | ||||||||
ChEMBL | Binding constant for TLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8] | ||||||||
ChEMBL | Binding constant for TLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385] | ||||||||
ChEMBL | Binding constant for ULK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8] | ||||||||
ChEMBL | Binding constant for ULK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2] | ||||||||
ChEMBL | Binding constant for ULK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07] | ||||||||
ChEMBL | Binding constant for VRK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291] | ||||||||
ChEMBL | Binding constant for WEE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for WEE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SNF related kinase/SNF-related serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2] | ||||||||
ChEMBL | Binding constant for SNRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
mitogen-activated protein kinase kinase kinase 19/SPS1/STE20-related protein kinase YSK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5] | ||||||||
ChEMBL | Binding constant for YSK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8] | ||||||||
ChEMBL | Binding constant for STK39 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Binding constant for KIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for KIT(D816V) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for KIT(V559D,T670I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for KIT(V559D,V654A) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for KIT(V559D) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding affinity to human KIT incubated for 1 hr by kinase binding assay | B | 5 | pKd | >10000 | nM | Kd | Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632] |
ChEMBL | Binding affinity to human KIT D816V mutant incubated for 1 hr by kinase binding assay | B | 5 | pKd | >10000 | nM | Kd | Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632] |
ChEMBL | Binding constant for KIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(A829P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(D816H) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(D816V) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(L576P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(V559D) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(V559D,T670I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for KIT(V559D,V654A) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7] | ||||||||
ChEMBL | Binding constant for full-length TSSK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TSSK1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
ChEMBL | Binding constant for TGFBR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TGFBR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
ChEMBL | Binding constant for TGFBR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TGFBR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5] | ||||||||
ChEMBL | Binding constant for TNIK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TNIK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84] | ||||||||
ChEMBL | Binding constant for TRPM6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tubulin alpha 1a/Tubulin alpha-1 chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370] | ||||||||
ChEMBL | Binding constant for ERBB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640] | ||||||||
ChEMBL | Binding constant for PKMYT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for PKMYT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
ChEMBL | Binding constant for TNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Binding constant for ABL1-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(F317L)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(F317L)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(H396P)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(H396P)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(M351T)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(Q252H)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(Q252H)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(T315I)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(T315I)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(Y253F)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(E255K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ABL1(T315I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ABL1(E255K)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(F317I)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for ABL1(F317I)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for ABL1(E255K); NA=Not Active at 10 uM | B | 5.14 | pKd | 7200 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for ABL1(H396P) kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ABL1(Q252H) kinase domain | B | 5.66 | pKd | 2200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Average Binding Constant for ABL1(M351T); NA=Not Active at 10 uM | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Average Binding Constant for ABL1(Q252H); NA=Not Active at 10 uM | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for ABL1(M351T) kinase domain | B | 5.82 | pKd | 1500 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ABL1(Y253F) kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Average Binding Constant for ABL1(H396P); NA=Not Active at 10 uM | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Average Binding Constant for ABL1; NA=Not Active at 10 uM | B | 6.06 | pKd | 870 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for ABL1 kinase domain | B | 6.14 | pKd | 730 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Average Binding Constant for ABL1(Y253F); NA=Not Active at 10 uM | B | 6.15 | pKd | 710 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Inhibition of human ABL1 | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2019) 62: 5298-5311 [PMID:30978288] |
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] | ||||||||
ChEMBL | Binding constant for ABL2 kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ABL2 kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for ABL2; NA=Not Active at 10 uM | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Inhibition of human ABL2 | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2019) 62: 5298-5311 [PMID:30978288] |
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
ChEMBL | Binding constant for BLK kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BLK kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813] | ||||||||
ChEMBL | Binding constant for full-length BMX | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BMX kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] | ||||||||
ChEMBL | Binding constant for PTK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
ChEMBL | Binding constant for full-length BTK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for BTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] | ||||||||
ChEMBL | Binding constant for full-length CSK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for CSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
megakaryocyte-associated tyrosine kinase/Tyrosine-protein kinase CTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679] | ||||||||
ChEMBL | Binding constant for CTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
FER tyrosine kinase/Tyrosine-protein kinase FER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591] | ||||||||
ChEMBL | Binding constant for FER kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FER kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332] | ||||||||
ChEMBL | Binding constant for FES kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FES kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] | ||||||||
ChEMBL | Binding constant for FGR kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FGR kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for FGR; NA=Not Active at 10 uM | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685] | ||||||||
ChEMBL | Binding constant for FRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for FRK; NA=Not Active at 10 uM | B | 5.48 | pKd | 3300 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Binding constant for FYN kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FYN kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631] | ||||||||
ChEMBL | Average Binding Constant for HCK; NA=Not Active at 10 uM | B | 5 | pKd | 10000 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for HCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for HCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
ChEMBL | Binding constant for ITK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ITK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of ITK by filter binding assay | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
ChEMBL | Binding constant for JAK1(Kin.Dom.1/JH2 - pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for JAK1(JH2domain-pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for JAK1(JH1domain-catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for JAK2(JH1domain-catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for JAK3(JH1domain-catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Binding constant for LCK kinase domain | B | 5.34 | pKd | 4600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LCK kinase domain | B | 5.34 | pKd | 4600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for LCK; NA=Not Active at 10 uM | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
ChEMBL | Binding constant for LYN kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for LYN kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
ChEMBL | Binding constant for FLT3(ITD) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT3(N841I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT3(D835H) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT3(D835Y) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FLT3(D835H) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FLT3(D835Y) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FLT3(ITD) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FLT3(K663Q) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FLT3(N841I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for FLT3(R834Q) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
ChEMBL | Binding constant for RET kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RET(M918T) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for RET kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RET(M918T) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RET(V804L) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for RET(V804M) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590] | ||||||||
ChEMBL | Binding constant for TIE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TIE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418] | ||||||||
ChEMBL | Binding constant for TYRO3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TYRO3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
ChEMBL | Binding constant for AXL kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for AXL kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Binding constant for SRC kinase domain | B | 5.26 | pKd | 5500 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SRC kinase domain | B | 5.26 | pKd | 5500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Average Binding Constant for SRC; NA=Not Active at 10 uM | B | 6.01 | pKd | 980 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Inhibition of SRC by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
ChEMBL | Inhibition of human SRC | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2019) 62: 5298-5311 [PMID:30978288] |
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6] | ||||||||
ChEMBL | Binding constant for SRMS kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SRMS kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Binding constant for SYK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for SYK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of SYK by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680] | ||||||||
ChEMBL | Binding constant for TEC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TEC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
ChEMBL | Binding constant for TIE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TIE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] | ||||||||
ChEMBL | Binding constant for TXK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TXK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
ChEMBL | Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for TYK2(JH1domain-catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Binding constant for TYK2(JH2domain-pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
ChEMBL | Average Binding Constant for YES; NA=Not Active at 10 uM | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
ChEMBL | Binding constant for YES kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for YES kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Binding constant for ZAP70 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ZAP70 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of ZAP70 by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53] | ||||||||
ChEMBL | Binding constant for full-length ADCK4 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for ADCK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
ChEMBL | Binding constant for FLT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Binding constant for VEGFR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for VEGFR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL | Inhibition of KDR by filter binding assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 758-763 [PMID:24900264] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Binding constant for FLT4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
ChEMBL | Binding constant for FLT4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8] | ||||||||
ChEMBL | Binding constant for WEE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]