ChEMBL ligand: CHEMBL625 (E233, Equizole, Lombristop, Mintezol, Minzolum, MK-360, Nemapan, NSC-525040, NSC-90507, Omnizole, Pitrizet, Thiabendazole, Thiabenzole, Tiabendazole)
CYP1A2/Cytochrome P450 1A2 in Human [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!
Methionine aminopeptidase in Escherichia coli [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18] There should be some charts here, you may need to enable JavaScript!
Methionyl aminopeptidase 1/Methionine aminopeptidase 1 in Human [ChEMBL: CHEMBL2474] [GtoPdb: 1572] [UniProtKB: P53582] There should be some charts here, you may need to enable JavaScript!
Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177]
ChEMBL	DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	6.1	pIC50	800	nM	IC50	DrugMatrix in vitro pharmacology data
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942]
ChEMBL	Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry	B	4.22	pKd	60000	nM	Kd	J Med Chem (2007) 50: 6607-6617 [PMID:18038971]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTP	B	4.84	pIC50	14600	nM	IC50	J Med Chem (2002) 45: 5410-5413 [PMID:12431069]
Methionine aminopeptidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18]
ChEMBL	Inhibition of Co2+ loaded MetAP expressed in Escherichia coli	B	6.33	pIC50	472	nM	IC50	J Med Chem (2006) 49: 511-522 [PMID:16420038]
Methionyl aminopeptidase 1/Methionine aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2474] [GtoPdb: 1572] [UniProtKB: P53582]
ChEMBL	Inhibition of human MetAP1	B	4.32	pIC50	47800	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4038-4044 [PMID:20621724]
ChEMBL	Inhibition of human methionine aminopeptidase 1 in presence of Mn2+	B	4	pEC50	>100000	nM	EC50	J Med Chem (2013) 56: 3996-4016 [PMID:23634668]
ChEMBL	Inhibition of human methionine aminopeptidase 1 in presence of Co2+	B	5.47	pEC50	3400	nM	EC50	J Med Chem (2013) 56: 3996-4016 [PMID:23634668]
Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579]
ChEMBL	Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells	B	4.35	pIC50	44700	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4038-4044 [PMID:20621724]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]