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ChEMBL ligand: CHEMBL266497 (CP-45,634, CP-45634, NSC-355082, Sorbinil) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
ChEMBL | Tested for in vitro inhibition activity against human aldehyde reductase (AHR) | B | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (2000) 43: 2479-2483 [PMID:10882376] |
ChEMBL | Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehyde | B | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (2005) 48: 5536-5542 [PMID:16107153] |
ChEMBL | Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction | B | 5.34 | pIC50 | 4600 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
Aldehyde reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4049] [UniProtKB: P50578] | ||||||||
ChEMBL | Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehyde | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2005) 48: 5536-5542 [PMID:16107153] |
ChEMBL | Inhibitory activity measured against pig kidney aldehyde reductase using 3-pyridinecarboxaldehyde as substrate | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (1991) 34: 1011-1018 [PMID:1900532] |
Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635] | ||||||||
ChEMBL | Evaluated for inhibition of Aldehyde reductase 1 | B | 5.76 | pIC50 | 1740 | nM | IC50 | J Med Chem (1996) 39: 4396-4405 [PMID:8893834] |
ChEMBL | In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney. | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2003) 46: 1419-1428 [PMID:12672241] |
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
ChEMBL | Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
ChEMBL | Inhibitory activity against human placental aldose reductase in Sepharose 4B column at day 7 | B | 5.14 | pIC50 | 7200 | nM | IC50 | J Med Chem (1985) 28: 841-849 [PMID:3925146] |
GtoPdb | - | - | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (2000) 43: 2479-83 [PMID:10882376] |
ChEMBL | Inhibitory activity against human placental aldose reductase in Sepharose 4B column at time 1 | B | 5.33 | pIC50 | 4700 | nM | IC50 | J Med Chem (1985) 28: 841-849 [PMID:3925146] |
ChEMBL | In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined | B | 5.44 | pIC50 | 3600 | nM | IC50 | J Med Chem (2003) 46: 5208-5221 [PMID:14613323] |
ChEMBL | Inhibition of ALR2 (unknown origin) | B | 5.5 | pIC50 | 3140 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127664-127664 [PMID:33152379] |
ChEMBL | Tested for in vitro inhibition activity against human Aldose reductase (human AR) | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2000) 43: 2479-2483 [PMID:10882376] |
ChEMBL | Inhibition of aldose reductase | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem (2007) 15: 7865-7877 [PMID:17870536] |
ChEMBL | Inhibitory concentration against human ALR2 | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2005) 48: 5536-5542 [PMID:16107153] |
ChEMBL | Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 4870-4874 [PMID:27666634] |
ChEMBL | Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-perturbation assay | B | 5.8 | pIC50 | 1580 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
ChEMBL | Inhibitory activity against human placenta aldose reductase | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1985) 28: 1716-1720 [PMID:3934383] |
ChEMBL | Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-perturbation assay | B | 6.01 | pIC50 | 971 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
ChEMBL | Inhibitory Activity against Human recombinant Aldose Reductase (wild type) | B | 6.04 | pIC50 | 918.6 | nM | IC50 | J Med Chem (2000) 43: 1062-1070 [PMID:10737739] |
ChEMBL | Inhibition of human recombinant aldose reductase | B | 6.04 | pIC50 | 910 | nM | IC50 | Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015] |
ChEMBL | Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured after 30 mins at 2 mins interval by spectrophotometry relative to control | B | 6.12 | pIC50 | 750 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibitory activity against human placental aldose reductase in 30 -70% (NH4)2SO4. | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (1985) 28: 841-849 [PMID:3925146] |
ChEMBL | Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction | B | 6.26 | pIC50 | 550 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
ChEMBL | In vitro inhibitory activity towards human placenta aldose reductase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1988) 31: 230-243 [PMID:3121857] |
ChEMBL | Inhibitory activity against human placental aldose reductase (HPAR) with glyceraldehyde as substrate | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1989) 32: 1208-1213 [PMID:2498517] |
ChEMBL | Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (1992) 35: 2085-2094 [PMID:1597858] |
ChEMBL | Inhibition of aldose reductase | B | 6.6 | pIC50 | 249 | nM | IC50 | Eur J Med Chem (2010) 45: 1663-1666 [PMID:20071057] |
ChEMBL | In vitro inhibitory activity against Aldose reductase isolated from human placenta | F | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (1990) 33: 1859-1865 [PMID:2113948] |
ChEMBL | In vitro inhibitroy concentration against Aldose reductase incubated at 24 degree C for 15 minutes in pH 7.0 | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2005) 48: 6326-6339 [PMID:16190759] |
ChEMBL | In vitro inhibitory activity against human recombinant Aldose reductase in streptozotocin diabetic rat at 50 mg/kg | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2003) 46: 2283-2286 [PMID:12773033] |
ChEMBL | Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrate | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (1989) 32: 1208-1213 [PMID:2498517] |
ChEMBL | Inhibition of aldose reductase | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem (2010) 18: 2107-2114 [PMID:20189816] |
ChEMBL | In vitro inhibition of rabbit lens aldose reductase. | B | 7.17 | pIC50 | 67 | nM | IC50 | J Med Chem (1986) 29: 2347-2351 [PMID:3097317] |
Aldose reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4559] [UniProtKB: P80276] | ||||||||
ChEMBL | Inhibition of aldose reductase from pig lenses | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2004) 47: 5076-5084 [PMID:15456251] |
Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116] | ||||||||
ChEMBL | Inhibition of ALR2 in calf lenses using DL-glyceraldehyde as substrate treated with compound for 10 mins prior to substrate addition by UV spectrophotometer analysis | B | 5.5 | pIC50 | 3140 | nM | IC50 | Eur J Med Chem (2015) 98: 127-138 [PMID:26005026] |
ChEMBL | Evaluated for inhibition of Aldose reductase 2 | B | 5.52 | pIC50 | 3040 | nM | IC50 | J Med Chem (1996) 39: 4396-4405 [PMID:8893834] |
ChEMBL | In vitro inhibitory activity against Aldose reductase 2 obtained from calf lenses | B | 5.52 | pIC50 | 3040 | nM | IC50 | J Med Chem (1999) 42: 1894-1900 [PMID:10354397] |
ChEMBL | Inhibition of bovine aldose reductase assessed as oxidation of NADPH | B | 5.7 | pIC50 | 2000 | nM | IC50 | Eur J Med Chem (2014) 81: 1-14 [PMID:24819954] |
ChEMBL | Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 200-203 [PMID:21129963] |
ChEMBL | Inhibition of bovine lens aldose reductase | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem (2010) 18: 4049-4055 [PMID:20452228] |
ChEMBL | Inhibition of bovine lens ALR2 | B | 5.7 | pIC50 | 2000 | nM | IC50 | Eur J Med Chem (2011) 46: 2797-2806 [PMID:21531055] |
ChEMBL | Inhibition of Aldose reductase 2 of bovine lens | B | 5.73 | pIC50 | 1850 | nM | IC50 | J Med Chem (1999) 42: 1881-1893 [PMID:10354396] |
ChEMBL | The compound was tested for Inhibitory effect against Aldose reductase 1 in bovine kidneys | B | 5.81 | pIC50 | 1560 | nM | IC50 | J Med Chem (1999) 42: 1881-1893 [PMID:10354396] |
ChEMBL | Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrate | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (1984) 27: 255-256 [PMID:6422042] |
ChEMBL | Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometry | B | 5.85 | pIC50 | 1410 | nM | IC50 | Bioorg Med Chem (2008) 16: 5840-5852 [PMID:18492610] |
ChEMBL | Inhibition of bovine aldose reductase | B | 5.85 | pIC50 | 1410 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3886-3893 [PMID:17512196] |
ChEMBL | In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-6 M concentration | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (1991) 34: 2504-2520 [PMID:1908522] |
ChEMBL | In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentration | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (1991) 34: 2504-2520 [PMID:1908522] |
ChEMBL | Inhibitory activity against bovine lens aldose reductase | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (1985) 28: 1716-1720 [PMID:3934383] |
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
ChEMBL | Inhibition of aldose reductase in rat lens by spectrophotometer analysis | B | 5.1 | pIC50 | 8000 | nM | IC50 | Eur J Med Chem (2014) 80: 209-217 [PMID:24780598] |
ChEMBL | Inhibition of rat kidney ALR1 using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured for 30 mins at 2 mins interval by spectrophotometry relative to control | B | 5.34 | pIC50 | 4570 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibition of Sprague-Dawley rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric method | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3068-3076 [PMID:28392277] |
ChEMBL | In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK) | B | 6 | pIC50 | 990 | nM | IC50 | J Med Chem (1991) 34: 3229-3234 [PMID:1956041] |
ChEMBL | Tested for in vitro inhibition activity against rat Aldose reductase (AR) | B | 6.05 | pIC50 | 900 | nM | IC50 | J Med Chem (2000) 43: 2479-2483 [PMID:10882376] |
ChEMBL | Inhibitory concentration against rat ALR2 aldose reductase | B | 6.05 | pIC50 | 900 | nM | IC50 | J Med Chem (2005) 48: 5536-5542 [PMID:16107153] |
ChEMBL | Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lens | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2001) 44: 4359-4369 [PMID:11728182] |
ChEMBL | In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction. | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2003) 46: 1419-1428 [PMID:12672241] |
ChEMBL | Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometry | B | 6.21 | pIC50 | 620 | nM | IC50 | Eur J Med Chem (2010) 45: 909-914 [PMID:19962793] |
ChEMBL | In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction. | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2003) 46: 1419-1428 [PMID:12672241] |
ChEMBL | Inhibition of rat lenses ALR2 using DL-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 4 mins | B | 6.37 | pIC50 | 430 | nM | IC50 | Eur J Med Chem (2016) 124: 750-762 [PMID:27639366] |
ChEMBL | Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (1991) 34: 1011-1018 [PMID:1900532] |
ChEMBL | In vitro inhibitory activity of compound against rat lens aldose reductase | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2004) 47: 2706-2709 [PMID:15115413] |
ChEMBL | Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysis | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem (2010) 18: 2107-2114 [PMID:20189816] |
ChEMBL | Inhibition of rat lens ALR2 | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2010) 53: 7756-7766 [PMID:20936791] |
ChEMBL | Inhibition of Fischer-344 rat lens ALR2 using D-glycuronate as substrate by spectrophotometry | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem (2013) 21: 869-873 [PMID:23312612] |
ChEMBL | Inhibition of partially purified Fischer-344 rat lens ALR2 using D,L-glyceraldehyde as substrate assessed as NADPH consumption by spectrophotometry | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem (2013) 21: 4951-4957 [PMID:23891165] |
ChEMBL | Inhibition of Fischer-344 rat lens ALR2 using D, L-glyceraldehyde as substrate by spectrophotometry | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem (2014) 22: 2194-2207 [PMID:24630695] |
ChEMBL | Inhibition of aldose reductase in rat lenses | B | 6.6 | pIC50 | 249 | nM | IC50 | Bioorg Med Chem (2008) 16: 3926-3932 [PMID:18267362] |
ChEMBL | Inhibition of aldose reductase from rat lens. Value ranges from 0.07 - 1.2 | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (1989) 32: 1033-1038 [PMID:2496229] |
ChEMBL | Inhibitory activity against rat lens aldose reductase | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (1985) 28: 1716-1720 [PMID:3934383] |
ChEMBL | Inhibitory activity against aldose reductase in rat lens | B | 6.72 | pIC50 | 190 | nM | IC50 | J Med Chem (1991) 34: 2120-2126 [PMID:1906108] |
ChEMBL | Inhibitory concentration against aldose reductase obtained from rat lens | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (1989) 32: 145-151 [PMID:2491890] |
ChEMBL | In vitro inhibition of Aldose reductase (AR) from rat lens (RL) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1991) 34: 3229-3234 [PMID:1956041] |
ChEMBL | Concentration required to produce 50% inhibition of aldose reductase enzyme (the literature IC50 value for sorbinil is 0.07 uM) | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1987) 30: 1595-1598 [PMID:3114491] |
ChEMBL | The compound was tested for the inhibition of Aldose reductase in rat lens assay. | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (1991) 34: 2120-2126 [PMID:1906108] |
ChEMBL | Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lens | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1986) 29: 627-629 [PMID:3084783] |
ChEMBL | Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type) | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1986) 29: 1094-1099 [PMID:3086557] |
ChEMBL | Inhibition of crude aldose reductase of rat lens | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1986) 29: 2024-2028 [PMID:3093680] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]