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ChEMBL ligand: CHEMBL1885748 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
ChEMBL | Inhibition of CLK2 (unknown origin) | B | 6.64 | pIC50 | 231 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
GtoPdb | - | - | 6.64 | pIC50 | 231 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479] |
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
ChEMBL | Inhibition of CLK3 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
ChEMBL | Inhibition of CLK4 (unknown origin) by bioluminescence assay | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
ChEMBL | Inhibition of CLK4 (unknown origin) | B | 7.17 | pIC50 | 68 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
GtoPdb | - | - | 7.17 | pIC50 | 68 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
ChEMBL | Inhibition of DYRK1A (unknown origin) by bioluminescence assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
ChEMBL | Inhibition of DYRK1A (unknown origin) | B | 6.55 | pIC50 | 282 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
GtoPdb | - | - | 6.55 | pIC50 | 282 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479] |
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
ChEMBL | Inhibition of DYRK1B (unknown origin) | B | 5.94 | pIC50 | 1156 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Inhibition of CLK1 (unknown origin) | B | 7.17 | pIC50 | 68 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
GtoPdb | - | - | 7.17 | pIC50 | 68 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]