compound 3 [PMID: 23849879] [Ligand Id: 8488] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1413622 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| kallikrein related peptidase 14/Kallikrein 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2641] [GtoPdb: 2866] [UniProtKB: Q9P0G3] | ||||||||
| ChEMBL | Inhibition of human kallikrein 14 measured after 15 mins at pH 8 by fluorescence assay | B | 5.89 | pIC50 | 1290 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879] |
| GtoPdb | - | - | 5.89 | pIC50 | 1290 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879] |
| kallikrein related peptidase 5/Kallikrein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4447] [GtoPdb: 2375] [UniProtKB: Q9Y337] | ||||||||
| ChEMBL | Inhibition of human kallikrein 5 measured after 15 mins at pH 8 by double-reciprocal plot analysis | B | 5.36 | pKi | 4400 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879] |
| ChEMBL | Inhibition of human kallikrein 5 measured after 15 mins at pH 8 by fluorescence assay | B | 6.57 | pIC50 | 270 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879] |
| GtoPdb | - | - | 6.57 | pIC50 | 270 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879] |
| kallikrein related peptidase 7/Kallikrein 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2443] [GtoPdb: 2377] [UniProtKB: P49862] | ||||||||
| ChEMBL | Inhibition of human kallikrein 7 measured after 15 mins at pH 8 by fluorescence assay | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879] |
| GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879] |
| ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6] | ||||||||
| GtoPdb | - | - | 6.24 | pIC50 | 570 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879] |
| ChEMBL | Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay | B | 6.24 | pIC50 | 570 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
