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ChEMBL ligand: CHEMBL227744 (L-Nitroarginine, L-N-Nitroarginine, L-Nw-Nitroarginine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline | B | 6.3 | pKi | 500 | nM | Ki | Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512] |
GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1998) 41: 2858-71 [PMID:9667974] |
ChEMBL | Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme. | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1998) 41: 2858-2871 [PMID:9667974] |
ChEMBL | Inhibition of human nNOS by hemoglobin capture assay | B | 5.36 | pIC50 | 4400 | nM | IC50 | J Med Chem (2009) 52: 4533-4537 [PMID:19537690] |
ChEMBL | Inhibition of cloned (from RNA) human Neuronal nitric oxide synthase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1998) 41: 3675-3683 [PMID:9733492] |
ChEMBL | Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
ChEMBL | Concentration required to inhibit neuronal nitric oxide synthase | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
Neuronal NOS/Nitric-oxide synthase, brain in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4719] [GtoPdb: 1251] [UniProtKB: Q9Z0J4] | ||||||||
ChEMBL | Inhibition of neuronal nitric oxide synthase (nNOS) in mice | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 313-316 [PMID:14698148] |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | Inhibition of rat recombinant nNOS | B | 5.34 | pKi | 4550 | nM | Ki | J Med Chem (2010) 53: 7804-7824 [PMID:20958055] |
ChEMBL | Inhibition of wild type rat nNOS by hemoglobin capture assay | B | 5.22 | pIC50 | 6000 | nM | IC50 | J Med Chem (2009) 52: 4533-4537 [PMID:19537690] |
ChEMBL | Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem (2012) 20: 2435-2443 [PMID:22370337] |
ChEMBL | Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem (2012) 20: 2435-2443 [PMID:22370337] |
ChEMBL | Inhibition of rat nNOS L337H mutant by hemoglobin capture assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2009) 52: 4533-4537 [PMID:19537690] |
ChEMBL | Inhibitory activity against isomeric form of Neuronal nitric oxide synthase measured by citrulline assay | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (1998) 41: 2636-2642 [PMID:9651169] |
ChEMBL | Compound was tested in vitro for inhibitory activity against nNOS (constitutive isoform found in neurons) | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 999-1002 |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
GtoPdb | - | - | 7.52 | pKi | 30 | nM | Ki | J Med Chem (1998) 41: 2858-71 [PMID:9667974] |
ChEMBL | Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme. | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (1998) 41: 2858-2871 [PMID:9667974] |
ChEMBL | Inhibition of cloned (from RNA) human endothelial constitutive Endothelial nitric oxide synthase (heNOS) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1998) 41: 3675-3683 [PMID:9733492] |
ChEMBL | Inhibitory concentration against recombinant human Endothelial nitric oxide synthase | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
ChEMBL | In vitro inhibition of endothelial nitric oxide synthase. | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
ChEMBL | Inhibition of bovine recombinant eNOS | B | 6.12 | pKi | 750 | nM | Ki | J Med Chem (2010) 53: 7804-7824 [PMID:20958055] |
ChEMBL | Inhibition of bovine recombinant endothelial NOS by hemoglobin capture assay | B | 6.14 | pKi | 720 | nM | Ki | J Med Chem (2007) 50: 2089-2099 [PMID:17425297] |
ChEMBL | Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase from cultured bovine aortic endothelial cells | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (1998) 41: 2636-2642 [PMID:9651169] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
GtoPdb | - | - | 6.17 | pKi | 670 | nM | Ki | J Med Chem (1998) 41: 2858-71 [PMID:9667974] |
ChEMBL | Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. | B | 6.17 | pKi | 670 | nM | Ki | J Med Chem (1998) 41: 2858-2871 [PMID:9667974] |
ChEMBL | Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS) | B | 5.12 | pIC50 | 7600 | nM | IC50 | J Med Chem (1998) 41: 3675-3683 [PMID:9733492] |
ChEMBL | Inhibitory concentration against human Inducible nitric oxide synthase | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
ChEMBL | In vitro inhibition of inducible nitric oxide synthase. | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
ChEMBL | Inhibition of mouse recombinant inducible NOS by hemoglobin capture assay | B | 5.37 | pKi | 4280 | nM | Ki | J Med Chem (2007) 50: 2089-2099 [PMID:17425297] |
ChEMBL | Inhibition of mouse recombinant iNOS | B | 6.24 | pKi | 570 | nM | Ki | J Med Chem (2010) 53: 7804-7824 [PMID:20958055] |
ChEMBL | Inhibition of inducible nitric oxide synthase (iNOS) in mice | B | 4.1 | pIC50 | 80000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 313-316 [PMID:14698148] |
ChEMBL | Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide overproduction incubated for 24 hrs by Griess assay | B | 4.56 | pIC50 | 27550 | nM | IC50 | Bioorg Med Chem (2020) 28: 115733-115733 [PMID:33065432] |
ChEMBL | Inhibition of inducible NOS mediated nitric oxide production in LPS-activated Kunming mouse macrophages | B | 4.83 | pIC50 | 14740 | nM | IC50 | Bioorg Med Chem (2008) 16: 578-585 [PMID:17937988] |
ChEMBL | Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (1998) 41: 2636-2642 [PMID:9651169] |
ChEMBL | Compound was tested in vitro for inhibitory activity against inducible nitric oxide synthase | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 999-1002 |
ChEMBL | Tested for inhibition of mouse inducible nitric oxide synthase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1994) 37: 3886-3888 [PMID:7525961] |
Inducible NOS/Nitric oxide synthase, inducible in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3051] [GtoPdb: 1250] [UniProtKB: Q06518] | ||||||||
ChEMBL | Tested for inhibition of rat brain inducible nitric oxide synthase | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (1994) 37: 3886-3888 [PMID:7525961] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]