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ChEMBL ligand: CHEMBL290376 (DuP-714) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
ChEMBL | In vitro for inhibition of plasmin | B | 8.29 | pKi | 5.1 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913-2918 |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
ChEMBL | Binding affinity against Thrombin. | B | 10.39 | pKd | 0.04 | nM | Kd | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Inhibition of Coagulation factor II | B | 10.38 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 925-930 [PMID:10230612] |
ChEMBL | Inhibition constant for binding with thrombin was determined | B | 10.39 | pKi | 0.04 | nM | Ki | J Med Chem (1993) 36: 1831-1838 [PMID:8515421] |
ChEMBL | In vitro for inhibition of thrombin. | B | 10.39 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913-2918 |
GtoPdb | Affinity for thrombin active site. | - | 10.39 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913–2918 |
ChEMBL | Inhibition of thrombin | B | 10.4 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 1595-1600 |
ChEMBL | Inhibition of compound against thrombin mediated platelet activation and fibrinogen cleavage. | B | 10.4 | pKi | 0.04 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735] | ||||||||
ChEMBL | Concentration necessary to double time for clot formation induced by bovine thrombin | B | 7.26 | pKi | 55 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913-2918 |
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] | ||||||||
GtoPdb | - | - | 8.24 | pKi | 5.7 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913–2918 |
ChEMBL | Compound was tested in vitro for inhibition of tissue plasminogen activator | B | 8.24 | pKi | 5.7 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913-2918 |
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] | ||||||||
ChEMBL | Inhibitory activity against trypsin | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 925-930 [PMID:10230612] |
ChEMBL | Inhibition of trypsin | B | 10.35 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 1595-1600 |
ChEMBL | Binding affinity against Trypsin | B | 10.35 | pKi | 0.04 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Compound was tested in vitro for inhibition of trypsin | B | 10.35 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2913-2918 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]