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ChEMBL ligand: CHEMBL205742 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Monocarboxylate transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4360] [GtoPdb: 988] [UniProtKB: P53985] | ||||||||
ChEMBL | Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione from MCT1 in human Jurkat cell membranes | B | 7.51 | pKi | 30.9 | nM | Ki | Nat Chem Biol (2005) 1: 371-376 [PMID:16370372] |
ChEMBL | Binding affinity to MCT1 by SPA | B | 8.32 | pKi | 4.8 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2260-2265 [PMID:16455256] |
ChEMBL | Binding affinity to MCT1 | B | 8.32 | pKi | 4.8 | nM | Ki | J Med Chem (2007) 50: 254-263 [PMID:17228867] |
GtoPdb | - | - | 8.32 | pKi | 4.8 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2260-5 [PMID:16455256] |
ChEMBL | Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione from human MCT1 expressed in INS1 cell membrane | B | 8.48 | pKi | 3.31 | nM | Ki | Nat Chem Biol (2005) 1: 371-376 [PMID:16370372] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]