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ChEMBL ligand: CHEMBL429852 (SP-4206) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Interleukin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5880] [UniProtKB: P60568] | ||||||||
ChEMBL | Binding affinity to IL2 (unknown origin) by SPR assay | B | 7 | pKd | 100 | nM | Kd | J Med Chem (2021) 64: 17496-17510 [PMID:34821503] |
ChEMBL | Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction | B | 7.22 | pKi | 60 | nM | Ki | Nature (2007) 450: 1001-1009 [PMID:18075579] |
ChEMBL | Binding affinity to IL2 (unknown origin) assessed as inhibition of binding to IL2 receptor alpha | B | 7.22 | pIC50 | 60 | nM | IC50 | Med Chem Res (2013) 22: 5739-5751 |
Interleukin-2 receptor subunit α/Interleukin-2 receptor alpha chain in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3287] [GtoPdb: 1695] [UniProtKB: P01590] | ||||||||
ChEMBL | Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2004) 47: 3111-3130 [PMID:15163192] |
ChEMBL | Effective concentration required against phosphorylation of Mammary gland factor/STAT5 | F | 8.52 | pEC50 | 3 | nM | EC50 | J Med Chem (2004) 47: 3111-3130 [PMID:15163192] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]