Synonyms: compound 3 [PMID: 29960205] | Fetcroja® | Fetroja® | GSK-2696266 | GSK2696266 | RSC 649266 | RSC-649266 | RSC649266 | S-649266
cefiderocol is an approved drug (FDA (2019), EMA (2020))
Compound class:
Synthetic organic
Comment: Cefiderocol (S-649266) is a novel parenteral cephalosporin antibacterial with Gram-negative activity including against multi-drug resistant bacteria [1,3]. Chemically it is a catechol-conjugated siderophore cephalosporin. It was developed to treat bloodstream infections, hospital-acquired and ventilator-associated bacterial pneumonia, and complicated urinary tract infections. It can be formulated as the sulphate tosylate complex. Cefiderocol was the first siderophore class antibacterial to be approved by FDA.
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Bioactivity Comments |
In vitro, the most potent antimicrobial activity was against KPC-2 producing Klebsiella pneumoniae (ATCC BAA-1705) [1]. The MIC for this strain was 0.063 μg/ml. |