Synonyms: Apatef® | Cefotan® | ICI-156834 | ICI156834
cefotetan is an approved drug (FDA (1985))
Compound class:
Synthetic organic
Comment: Cefotetan is a semi-synthetic, broad-spectrum, β-lactamase-resistant, second-generation cephalosporin antibacterial. Because of its inhibitory activity towards human aldehyde dehydrogenase, cefotetan produces an effect to ethanol similar to that produced by disulfiram (Antabuse).
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References |
1. Betriu C, Sánchez A, Palau ML, Gómez M, Picazo JJ. (2001)
In vitro activities of MK-0826 and 16 other antimicrobials against Bacteroides fragilis group strains. Antimicrob Agents Chemother, 45 (8): 2372-4. [PMID:11451700] |
2. Hoellman DB, Spangler SK, Jacobs MR, Appelbaum PC. (1998)
In vitro activities of cefminox against anaerobic bacteria compared with those of nine other compounds. Antimicrob Agents Chemother, 42 (3): 495-501. [PMID:9517922] |