Synonyms: Bleph-10® | Klaron® | sulphacetamide
sulfacetamide is an approved drug (FDA (1945))
Compound class:
Synthetic organic
Comment: Sulfacetamide is a sulfonamide antibacterial compound that has been in clinical use since the 1940s [3]. It inhibits the bacterial dihydropteroate synthase pathway which generates the folic acid that is essential for bacterial growth.
|
|
References |
1. Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK. (1997)
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nat Struct Biol, 4 (6): 490-7. [PMID:9187658] |
2. Bermingham A, Derrick JP. (2002)
The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays, 24 (7): 637-48. [PMID:12111724] |
3. DUEMLING WW. (1954)
Sodium sulfacetamide in topical therapy. AMA Arch Derm Syphilol, 69 (1): 75-82. [PMID:13113725] |
4. Ovung A, Bhattacharyya J. (2021)
Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions. Biophys Rev, 13 (2): 259-272. [PMID:33936318] |