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Your search for repurposing returned 92 results
Ligand: lebrikizumab
Clinical use: repurposed as a potential asthma treatment . The antibody entered Phase 2 trial for idiopathic pulmonary
Immuno Disease Ligand Comment: Repurposed clinical candidate for IPF (Phase 2).
Immuno Disease Ligand Comment: Repurposed clinical candidate for asthma (Phase 3).
Immuno Disease Ligand Comment: Repurposed clinical candidate for IPF (Phase 2).
Immuno Disease Ligand Comment: Repurposed clinical candidate for asthma (Phase 3).
Ligand: fluoxetine
Clinical use: repurposing candidates as potential therapeutics for secondary progressive multiple sclerosis (SPMS or late MS), having
Bioactivity comments: repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693) suggest that this antiviral activity
Bioactivity comments: repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693) suggest that this antiviral activity
Ligand: metformin
Comments: this could ultimately lead to metformin being repurposed for indications other than type 2 diabetes.
Immuno Ligand Comments: found to be effective, this could ultimately lead to metformin being repurposed for inflammatory indications .
Immuno Ligand Comments: found to be effective, this could ultimately lead to metformin being repurposed for inflammatory indications .
Disease: Idiopathic pulmonary fibrosis
Ligand association comment: Repurposed clinical candidate for IPF (Phase 2).
Target:
signal transducer and activator of transcription 3 (STAT transcription factors)
Receptor Immuno Comment: repurposed drug) inhibits binding of pSTAT3 to DNA. It has reached Phase 2 clinical development
Target:
basigin (Ok blood group) (CD molecules)
Receptor Immuno Comment: repurposed for COVID-19 pneumonia (caused by the coronavirus SARS-CoV-2). In this setting
Target:
A2A receptor (Adenosine receptors)
Receptor Immuno Comment: repurpose A2A receptor antagonists that have failed late stage clinical trials (Phase 3) as Parkinson
Target:
CoV 3C-like (main) protease (Coronavirus (CoV) proteins)
Inhibitors - comment: repurposing screen, which corroborated the inhibitory activity of boceprevir (and other hepatitis C NS3/4A protease
Ligand: SR8185
Immuno Ligand Comments: developed for their anticancer potential, may be suitable for repurposing as clinical agents for autoimmune diseases.
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