Sézary syndrome

Disease ID:1135
Name:Sézary syndrome
Associated with:1 target
Synonyms
Sézary lymphoma
Description
Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes.
Database Links
Orphanet: ORPHA3162

Targets

CXCR5
Role:  CXCR5 expression and a dense dermal infiltrate correlates with a poor prognosis in Sézary syndrome.
References:  1

Ligands

No ligand related data available for Sézary syndrome

References

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1. Capriotti E, Vonderheid EC, Thoburn CJ, Bright EC, Hess AD. (2007) Chemokine receptor expression by leukemic T cells of cutaneous T-cell lymphoma: clinical and histopathological correlations. J. Invest. Dermatol., 127 (12): 2882-92. [PMID:17597825]