Localized scleroderma

Disease ID:1241
Name:Localized scleroderma
Associated with:0 targets
0 immuno-relevant targets
1 immuno-relevant ligands
Synonyms
circumscribed scleroderma | localised morphea | morphea
Description
Localized scleroderma is scleroderma-like spectrum disorder that produces sclerosis of skin and underlying soft tissues.
Database Links
Disease Ontology: DOID:8472

Targets

No target related data available for Localized scleroderma

Ligands

Ligand Approved Immuno References Clinical comments
CXCL9 1
Immuno Disease Comments: Serum and lesional levels of CXCL9 are elevated in localized scleroderma. The serum concentration positively correlated with disease activity. CXCL9 co-localizes with CD68+ dermal macrophages by double-staining immunohistochemistry.

References

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1. O'Brien JC, Rainwater YB, Malviya N, Cyrus N, Auer-Hackenberg L, Hynan LS, Hosler GA, Jacobe HT. (2017) Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea. J. Invest. Dermatol., 137 (8): 1663-1670. [PMID:28450066]