Localized scleroderma

Disease ID:1241
Name:Localized scleroderma
Associated with:0 target
1 immuno-relevant ligand
Synonyms
circumscribed scleroderma | localised morphea | morphea
Description
Localized scleroderma is scleroderma-like spectrum disorder that produces sclerosis of skin and underlying soft tissues.
Database Links
Disease Ontology: DOID:8472

Targets

No target related data available for Localized scleroderma

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
CXCL9 1
Immuno Disease Comments: Serum and lesional levels of CXCL9 are elevated in localized scleroderma. The serum concentration positively correlated with disease activity. CXCL9 co-localizes with CD68+ dermal macrophages by double-staining immunohistochemistry.

References

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1. O'Brien JC, Rainwater YB, Malviya N, Cyrus N, Auer-Hackenberg L, Hynan LS, Hosler GA, Jacobe HT. (2017) Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea. J. Invest. Dermatol., 137 (8): 1663-1670. [PMID:28450066]