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Endometrial cancer

Disease ID:298
Name:Endometrial cancer
Associated with:5 targets
Database Links
Disease Ontology: DOID:1380
OMIM: 608089

Targets

PKR1
References:  3
Mutations:  PKR1 is associated with 2 mutation. Click here for details
Estrogen receptor-α
References:  1
Progesterone receptor
Comments:  Polymorphisms in the PR promoter favoring expression of PRB and demonstrated this mutation correlated with increased risk of endometrial cancer.
References:  2,4
TLR9
NLRP7

Ligands

No ligand related data available for Endometrial cancer

References

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1. Burke C. (2005) Endometrial cancer and tamoxifen. Clin J Oncol Nurs, 9 (2): 247-9. [PMID:15853168]

2. De Vivo I, Huggins GS, Hankinson SE, Lescault PJ, Boezen M, Colditz GA, Hunter DJ. (2002) A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk. Proc. Natl. Acad. Sci. U.S.A., 99 (19): 12263-8. [PMID:12218173]

3. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. (2013) The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat. Rev. Cancer, 13 (6): 412-24. [PMID:23640210]

4. Terry KL, De Vivo I, Titus-Ernstoff L, Sluss PM, Cramer DW. (2005) Genetic variation in the progesterone receptor gene and ovarian cancer risk. Am. J. Epidemiol., 161 (5): 442-51. [PMID:15718480]