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Endometriosis

Disease ID:299
Name:Endometriosis
Associated with:1 target
Database Links
Disease Ontology: DOID:289
OMIM: 607311

Targets

Progesterone receptor
Role:  Reduced expression of PR
Drugs:  Asoprisnil
Comments:  A study found that PRA, but not B, is expressed in diseased tissue, whereas both PRA and B are expressed in normal tissue. Further, asoprisnil, a PR partial agonist, has been used with some success to treat endometriosis.
References:  1-2

Ligands

No ligand related data available for Endometriosis

References

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1. Attia GR, Zeitoun K, Edwards D, Johns A, Carr BR, Bulun SE. (2000) Progesterone receptor isoform A but not B is expressed in endometriosis. J. Clin. Endocrinol. Metab., 85 (8): 2897-902. [PMID:10946900]

2. Chwalisz K, DeManno D, Garg R, Larsen L, Mattia-Goldberg C, Stickler T. (2004) Therapeutic potential for the selective progesterone receptor modulator asoprisnil in the treatment of leiomyomata. Semin. Reprod. Med., 22 (2): 113-9. [PMID:15164306]