Esophageal cancer

Disease ID:336
Name:Esophageal cancer
Associated with:4 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Database Links
Disease Ontology: DOID:5041
OMIM: 133239

Targets

CCR7
References:  1
FZD7
Comments:  FZD7 has been implcated in esophageal carcimoma.
References:  2,4
Retinoic acid receptor-β
Role:  Esophageal cancer is associated with RARb loss-of expression.
References:  3

Ligands

No ligand related data available for Esophageal cancer

References

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1. Ishida K, Iwahashi M, Nakamori M, Nakamura M, Yokoyama S, Iida T, Naka T, Nakamura Y, Yamaue H. (2009) High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma. Int. J. Oncol., 34 (4): 915-22. [PMID:19287948]

2. King TD, Zhang W, Suto MJ, Li Y. (2012) Frizzled7 as an emerging target for cancer therapy. Cell. Signal., 24 (4): 846-51. [PMID:22182510]

3. Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, Lotan R, Xu XC. (1999) Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis. Am. J. Pathol., 155 (5): 1519-23. [PMID:10550308]

4. Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. U.S.A., 95 (17): 10164-9. [PMID:9707618]