Hepatocellular carcinoma

Disease ID:422
Name:Hepatocellular carcinoma
Associated with:4 targets
Database Links
Disease Ontology: DOID:684
OMIM: 114550

Targets

FZD7
References:  1-4
Caspase 8
TLR2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Ligands

No ligand related data available for Hepatocellular carcinoma

References

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1. Bengochea A, de Souza MM, Lefran├žois L, Le Roux E, Galy O, Chemin I, Kim M, Wands JR, Trepo C, Hainaut P, Scoazec JY, Vitvitski L, Merle P. (2008) Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer, 99: 143-150. [PMID:18577996]

2. Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, Yu E, Merle P, Wands JR. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J. Hepatol., 48 (5): 780-91. [PMID:18313787]

3. King TD, Zhang W, Suto MJ, Li Y. (2012) Frizzled7 as an emerging target for cancer therapy. Cell. Signal., 24 (4): 846-51. [PMID:22182510]

4. Merle P, de la Monte S, Kim M, Herrmann M, Tanaka S, Von Dem Bussche A, Kew MC, Trepo C, Wands JR. (2004) Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology, 127 (4): 1110-22. [PMID:15480989]