Hypertension, essential

Disease ID:458
Name:Hypertension, essential
Associated with:3 targets
Database Links
Disease Ontology: DOID:10825
OMIM: 145500

Targets

AT1 receptor
References:  1,3,6
Endothelin-converting enzyme 1
regulator of G-protein signaling 2
References:  2,4-5,7

Ligands

No ligand related data available for Hypertension, essential

References

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1. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension, 24: 63-69. [PMID:8021009]

2. Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH et al.. (2003) Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J. Clin. Invest., 111 (4): 445-52. [PMID:12588882]

3. Kobashi G, Hata A, Ohta K, Yamada H, Kato EH, Minakami H, Fujimoto S, Kondo K. (2004) A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene. J. Hum. Genet., 49 (4): 182-6. [PMID:15042429]

4. Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA. (2006) Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension, 47 (3): 415-20. [PMID:16432041]

5. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y et al.. (2003) Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat. Med., 9 (12): 1506-12. [PMID:14608379]

6. Wang WY, Zee RY, Morris BJ. (1997) Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clin. Genet., 51: 31-34. [PMID:9084931]

7. Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A et al.. (2005) Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. J. Hypertens., 23 (8): 1497-505. [PMID:16003176]