Lung cancer

Disease ID:567
Name:Lung cancer
Associated with:13 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Database Links
Disease Ontology: DOID:1324
OMIM: 211980

Targets

ADGRB1
Role:  Mutations in ADGRB1 are associated with squamous cell carcinoma of the lung
References:  4
Mutations:  ADGRB1 is associated with 3 mutation. Click here for details
ADGRB2
Role:  Mutations in ADGRB2 are associated with squamous cell carcinoma of the lung and other forms of lung cancer
References:  4
Mutations:  ADGRB2 is associated with 3 mutation. Click here for details
ADGRB3
Role:  Mutations in BAI3 are associated with lung adenocarcinoma, squamous cell carcimoma and small cell carcinoma
References:  4
Mutations:  ADGRB3 is associated with 19 mutation. Click here for details
FZD7
References:  5,8
FZD8
References:  1,10
PKR1
References:  6
Mutations:  PKR1 is associated with 7 mutation. Click here for details
Retinoic acid receptor-β
Role:  Non-small-cell lung cancer is associated with RARb loss-of expression.
References:  2,7,11
Caspase 8
Role:  A deletion allele in CASP8 is associated with reduced risk of lung cancer
Mutations:  Caspase 8 is associated with 1 mutation. Click here for details
epidermal growth factor receptor
Role:  Mutations in EGFR are associated with non-small cell lung cancer and adenocarcinoma of the lung.
B-Raf proto-oncogene, serine/threonine kinase
Role:  Mutations in BRAF are associated with lung adenocarcinoma
erb-b2 receptor tyrosine kinase 2
Role:  Mutations in ERBB2 are associated with lung adenocarcinoma
regulator of G-protein signaling 12
Comments:  Non-small cell lung cancer
References:  3

Ligands

No ligand related data available for Lung cancer

References

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1. Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons DM, You L. (2013) Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer, 13: 316. [PMID:23815780]

2. Castillo L, Milano G, Santini J, Demard F, Pierrefite V. (1997) Analysis of retinoic acid receptor beta expression in normal and malignant laryngeal mucosa by a sensitive and routine applicable reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay method. Clin. Cancer Res., 3 (11): 2137-42. [PMID:9815607]

3. Dai J, Gu J, Lu C, Lin J, Stewart D, Chang D, Roth JA, Wu X. (2011) Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer. PLoS ONE, 6 (6): e21120. [PMID:21698121]

4. Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, Yue P, Haverty PM, Bourgon R, Zheng J, Moorhead M, Chaudhuri S, Tomsho LP, Peters BA, Pujara K, Cordes S, Davis DP, Carlton VE, Yuan W, Li L, Wang W, Eigenbrot C, Kaminker JS, Eberhard DA, Waring P, Schuster SC, Modrusan Z, Zhang Z, Stokoe D, de Sauvage FJ, Faham M, Seshagiri S. (2010) Diverse somatic mutation patterns and pathway alterations in human cancers. Nature, 466 (7308): 869-73. [PMID:20668451]

5. King TD, Zhang W, Suto MJ, Li Y. (2012) Frizzled7 as an emerging target for cancer therapy. Cell. Signal., 24 (4): 846-51. [PMID:22182510]

6. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. (2013) The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat. Rev. Cancer, 13 (6): 412-24. [PMID:23640210]

7. Picard E, Seguin C, Monhoven N, Rochette-Egly C, Siat J, Borrelly J, Martinet Y, Martinet N, Vignaud JM. (1999) Expression of retinoid receptor genes and proteins in non-small-cell lung cancer. J. Natl. Cancer Inst., 91 (12): 1059-66. [PMID:10379969]

8. Sagara N, Toda G, Hirai M, Terada M, Katoh M. (1998) Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. Biochem Biophys Res Commun, 252: 117-122. [PMID:9813155]

9. Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q et al.. (2007) A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat. Genet., 39 (5): 605-13. [PMID:17450141]

10. Wang HQ, Xu ML, Ma J, Zhang Y, Xie CH. (2012) Frizzled-8 as a putative therapeutic target in human lung cancer. Biochem. Biophys. Res. Commun., 417 (1): 62-6. [PMID:22138402]

11. Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R. (1997) Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development. J. Natl. Cancer Inst., 89 (9): 624-9. [PMID:9150186]