Schizophrenia 13; SCZD13

Disease ID:840
Name:Schizophrenia 13; SCZD13
Associated with:1 target
Synonyms
Schizophrenia
Database Links
Disease Ontology: DOID:5419
OMIM: 181500, 613025
Orphanet: ORPHA3140

Targets

nicotinic acetylcholine receptor α7 subunit
Role:  There is linkage between the α7 gene locus on chromosome 15 and auditory gating deficits common in schizophrenic patients. Polymorphisms in the promoter region of the α7 gene that reduce its transcription appear to be associated with schizophrenia. Brains of schizophrenics have reduced levels of α-bungarotoxin binding sites.
References:  1,3
Mutations:  nicotinic acetylcholine receptor α7 subunit is associated with 2 mutation. Click here for details

Ligands

No ligand related data available for Schizophrenia 13; SCZD13

References

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1. Freedman R, Hall M, Adler LE, Leonard S. (1995) Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol. Psychiatry, 38 (1): 22-33. [PMID:7548469]

2. Gault J, Robinson M, Berger R, Drebing C, Logel J, Hopkins J, Moore T, Jacobs S, Meriwether J, Choi MJ et al.. (1998) Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics, 52 (2): 173-85. [PMID:9782083]

3. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, Drebing C, Berger R, Venn D, Sirota P et al.. (2002) Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch. Gen. Psychiatry, 59 (12): 1085-96. [PMID:12470124]