Asthma, susceptibility to

Disease ID:86
Name:Asthma, susceptibility to
Associated with:12 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Database Links
Disease Ontology: DOID:2841
OMIM: 600807

Targets

β2-adrenoceptor
Comments:  Polymorphisms in ADRB2 are associated with susceptibility to nocturnal asthma.
CysLT2 receptor
Mutations:  CysLT2 receptor is associated with 1 mutation. Click here for details
Glucocorticoid receptor
Role:  Mutations in the GR gene
References:  1-2
5-LOX
Role:  Mutations in ALOX5 are associated with diminished response to antileukotriene treatment in asthma.

Ligands

No ligand related data available for Asthma, susceptibility to

References

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1. Barnes PJ, Greening AP, Crompton GK. (1995) Glucocorticoid resistance in asthma. Am. J. Respir. Crit. Care Med., 152 (6 Pt 2): S125-40. [PMID:7489120]

2. Corrigan CJ, Brown PH, Barnes NC, Szefler SJ, Tsai JJ, Frew AJ, Kay AB. (1991) Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am. Rev. Respir. Dis., 144 (5): 1016-25. [PMID:1952426]

3. Pillai SG, Cousens DJ, Barnes AA, Buckley PT, Chiano MN, Hosking LK, Cameron LA, Fling ME, Foley JJ, Green A et al.. (2004) A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pharmacogenetics, 14 (9): 627-33. [PMID:15475736]

4. Thompson MD, Storm van's Gravesande K, Galczenski H, Burnham WM, Siminovitch KA, Zamel N, Slutsky A, Drazen JM, George SR, Evans JF et al.. (2003) A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. Pharmacogenetics, 13 (10): 641-9. [PMID:14515063]