Thyroid carcinoma, follicular; FTC

Disease ID:924
Name:Thyroid carcinoma, follicular; FTC
Associated with:3 targets
Synonyms
Differentiated thyroid carcinoma | Follicular thyroid carcinoma
Database Links
Disease Ontology: DOID:3962
OMIM: 188470
Orphanet: ORPHA146

Targets

Peroxisome proliferator-activated receptor-γ
Comments:  PAX8-PPAR gamma fusion protein promotes differentiated follicular thyroid neoplasia
References:  1-3
HRAS
NRAS

Ligands

No ligand related data available for Thyroid carcinoma, follicular; FTC

References

Show »

1. Cheung L, Messina M, Gill A, Clarkson A, Learoyd D, Delbridge L, Wentworth J, Philips J, Clifton-Bligh R, Robinson BG. (2003) Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas. J. Clin. Endocrinol. Metab., 88 (1): 354-7. [PMID:12519876]

2. Marques AR, Espadinha C, Catarino AL, Moniz S, Pereira T, Sobrinho LG, Leite V. (2002) Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas. J. Clin. Endocrinol. Metab., 87 (8): 3947-52. [PMID:12161538]

3. Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW, Tallini G, Kroll TG, Nikiforov YE. (2003) RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J. Clin. Endocrinol. Metab., 88 (5): 2318-26. [PMID:12727991]