Traumatic and possibly ischemic brain injury

Disease ID:930
Name:Traumatic and possibly ischemic brain injury
Associated with:1 target

Targets

KCa3.1
Role:  KCa3.1 is involved in respiratory burst and microglia mediated neuronal killing
Drugs:  cyclohexadione 16, TRAM-34
Side effects:  none reported
Therapeutic use:  KCa3.1 blockers suggested for the treatment of brain injury
Comments:  cyclohexadione 16, TRAM-34 efficacy has been demonstrated in rat models of traumatic brain injury or optic nerve transcetion
References:  1-3

Ligands

No ligand related data available for Traumatic and possibly ischemic brain injury

References

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1. Kaushal V, Koeberle PD, Wang Y, Schlichter LC. (2007) The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration. J. Neurosci., 27 (1): 234-44. [PMID:17202491]

2. Khanna R, Roy L, Zhu X, Schlichter LC. (2001) K+ channels and the microglial respiratory burst. Am. J. Physiol., Cell Physiol., 280 (4): C796-806. [PMID:11245596]

3. Mauler F, Hinz V, Horváth E, Schuhmacher J, Hofmann HA, Wirtz S, Hahn MG, Urbahns K. (2004) Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. Eur. J. Neurosci., 20 (7): 1761-8. [PMID:15379997]