Lanosterol biosynthesis pathway C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and the mitochondrial generation of (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation of fatty acids.

Enzymes

acetyl-CoA acetyltransferase 1 C Show summary » More detailed page

acetyl-CoA acetyltransferase 2 C Show summary » More detailed page

hydroxymethylglutaryl-CoA synthase 1 C Show summary » More detailed page

hydroxymethylglutaryl-CoA synthase 2 C Show summary » More detailed page

hydroxymethylglutaryl-CoA reductase C Show summary » More detailed page

mevalonate kinase C Show summary » More detailed page

phosphomevalonate kinase C Show summary » More detailed page

diphosphomevalonate decarboxylase C Show summary » More detailed page

isopentenyl-diphosphate Δ-isomerase 1 C Show summary » More detailed page

isopentenyl-diphosphate Δ-isomerase 2 C Show summary » More detailed page

geranylgeranyl diphosphate synthase C Show summary » More detailed page

farnesyl diphosphate synthase C Show summary » More detailed page

squalene synthase C Show summary » More detailed page

squalene monooxygenase C Show summary » More detailed page

lanosterol synthase C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Helen E. Benson. Lanosterol biosynthesis pathway. Accessed on 16/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=104.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.