Kisspeptin, neuropeptide FF, prolactin-releasing peptide and QRFP receptors
Jump toKisspeptin (nomenclature agreed by NC-IUPHAR committee on kisspeptin receptors, Kirby et al., 2010 [12]), neuropeptide FF (NPFF), prolactin-releasing peptide (PrP) and QRFP receptors (provisional nomenclature) respond to endogenous peptides with an arginine-phenylalanine-amide (RFamide) motif. kisspeptin-54 (KP54, originally named metastin), kisspeptin-13 (KP13) and kisspeptin-10 (KP10) are biologically-active peptides cleaved from the KISS1 gene product (ENSG00000170498), while a single propeptide precursor (ENSG00000139574) generates the octapeptides NPFF (FLFQPQRF-NH2, neuropeptide FF or F-8-F-amide) and NPSF (SLAAPQRF-NH2, neuropeptide SF) and the octadecapeptide NPAF (AGEGLSSPFWSLAAPQRF-NH2, neuropeptide AF or A-18-F-amide). NPFF and NPAF were originally isolated from bovine brain [30]. The precursor (ENSG00000071677) for PrRP generates 31 and 20-amino-acid versions. QRFP (named after a pyroglutamylated arginine-phenylalanine-amide peptide) is a 43 amino acid peptide derived from ENSG00000188710 and is also known as P518 or 26RFa. RFRP is an RF amide-related peptide [10] derived from a FMRFamide-related peptide precursor (ENSG00000105954), which is cleaved to generate neuropeptide NPSF, neuropeptide RFRP-1, neuropeptide RFRP-2 and neuropeptide RFRP-3 (neuropeptide NPVF).
Kisspeptin receptor
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors 
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kisspeptin receptor Show »« Hide
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Neuropeptide FF/neuropeptide AF receptors
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors
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Prolactin-releasing peptide receptor
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors
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Peptide P518 receptor
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors
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Colledge, WH. (2009) Kisspeptins and GnRH neuronal signalling. Trends Endocrinol. Metab., 20 (3): 115-21. [PMID:19097915]
Fukusumi, S; Fujii, R; Hinuma, S. (2006) Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides, 27 (5): 1073-86. [PMID:16500002]
Hameed, S; Jayasena, CN; Dhillo, WS. (2011) Kisspeptin and fertility. J. Endocrinol., 208 (2): 97-105. [PMID:21084385]
Jayasena, CN; Dhillo, WS; Bloom, SR. (2009) Kisspeptins and the control of gonadotropin secretion in humans. Peptides, 30 (1): 76-82. [PMID:18656511]
Kirby, HR; Maguire, JJ; Colledge, WH; Davenport, AP. (2010) International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function. Pharmacol. Rev., 62 (4): 565-78. [PMID:21079036]
Mead, EJ; Maguire, JJ; Kuc, RE; Davenport, AP. (2007) Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br. J. Pharmacol., 151 (8): 1143-53. [PMID:17519946]
Millar, RP; Roseweir, AK; Tello, JA; Anderson, RA; George, JT; Morgan, K; Pawson, AJ. (2010) Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Brain Res., 1364: 81-9. [PMID:20858467]
Moulédous, L; Mollereau, C; Zajac, JM. (2010) Opioid-modulating properties of the neuropeptide FF system. Biofactors, 36 (6): 423-9. [PMID:20803521]
Oakley, AE; Clifton, DK; Steiner, RA. (2009) Kisspeptin signaling in the brain. Endocr. Rev., 30 (6): 713-43. [PMID:19770291]
Samson, WK; Taylor, MM. (2006) Prolactin releasing peptide (PrRP): an endogenous regulator of cell growth. Peptides, 27 (5): 1099-103. [PMID:16500730]
Seminara, SB. (2006) Mechanisms of Disease: the first kiss-a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction. Nat Clin Pract Endocrinol Metab, 2 (6): 328-34. [PMID:16932310]
Takayanagi, Y; Onaka, T. (2010) Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake. FEBS J., 277 (24): 4998-5005. [PMID:21126313]
Tena-Sempere, M. (2010) Kisspeptin signaling in the brain: recent developments and future challenges. Mol. Cell. Endocrinol., 314 (2): 164-9. [PMID:19464345]
Vyas, N; Mollereau, C; Chevé, G; McCurdy, CR. (2006) Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives. Peptides, 27 (5): 990-6. [PMID:16490282]
Yang, HY; Tao, T; Iadarola, MJ. (2008) Modulatory role of neuropeptide FF system in nociception and opiate analgesia. Neuropeptides, 42 (1): 1-18. [PMID:17854890]
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An orphan receptor GPR83 (ENSG00000123901) shows sequence similarities with NPFF1, NPFF2, PrRP and QRFP receptors. The antagonist RF9 is selective for NPFF receptors, but does not distinguish between the NPFF1 and NPFF2 subtypes (pKi 7.1 and 7.2, respectively, [26]).