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ATP-binding cassette transporter family

ATP-binding cassette transporter family C

Contents

Overview
Subfamilies
Comments
Further reading
References
NC-IUPHAR subcommittee and family contributors
How to cite this family page

Overview

ATP-binding cassette transporters are ubiquitous membrane proteins characterized by active ATP-dependent movement of a range of substrates, including ions, lipids, peptides, steroids. Individual subunits are typically made up of two groups of 6TM-spanning domains, with two nucleotide-binding domains (NBD). The majority of eukaryotic ABC transporters are ‘full’ transporters incorporating both TM and NBD entities. Some ABCs, notably the ABCD and ABCG families are half-transporters with only a single membrane spanning domain and one NBD, and are only functional as homo- or heterodimers. Eukaryotic ABC transporters convey substrates from the cytoplasm, either out of the cell or into intracellular organelles. Their role in the efflux of exogenous compounds, notably chemotherapeutic agents, has led to considerable interest.

Subfamilies

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ABCA subfamily C
ABCB subfamily C
ABCC subfamily C
ABCD subfamily of peroxisomal ABC transporters C
ABCG subfamily C

Comments

A further group of ABC transporter-like proteins have been identified to lack membrane spanning regions and are not believed to be functional transporters, but appear to have a role in protein translation [1-2]: ABCE1 (P61221, also known as OABP or 2'-5' oligoadenylate-binding protein); ABCF1 (Q8NE71, also known as ABC50 or TNF-α-stimulated ABC protein); ABCF2 (Q9UG63, also known as iron-inhibited ABC transporter 2) and ABCF3 (Q9NUQ8).

Further reading

* Key recommended reading is highlighted with an asterisk

* Aye IL, Singh AT, Keelan JA. (2009) Transport of lipids by ABC proteins: interactions and implications for cellular toxicity, viability and function. Chem. Biol. Interact., 180 (3): 327-39. [PMID:19426719]

Borst P, de Wolf C, van de Wetering K. (2007) Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch., 453 (5): 661-73. [PMID:16586096]

Bryan J, Muñoz A, Zhang X, Düfer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L. (2007) ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch., 453 (5): 703-18. [PMID:16897043]

Ecker GF, Stockner T, Chiba P. (2008) Computational models for prediction of interactions with ABC-transporters. Drug Discov. Today, 13 (7-8): 311-7. [PMID:18405843]

* Gutmann DA, Ward A, Urbatsch IL, Chang G, van Veen HW. (2010) Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1. Trends Biochem. Sci., 35 (1): 36-42. [PMID:19819701]

* Haenisch S, Werk AN, Cascorbi I. (2014) MicroRNAs and their relevance to ABC transporters. Br J Clin Pharmacol, 77 (4): 587-96. [PMID:24645868]

* Hinz A, Tampé R. (2012) ABC transporters and immunity: mechanism of self-defense. Biochemistry, 51 (25): 4981-9. [PMID:22668350]

* Kemp S, Theodoulou FL, Wanders RJ. (2011) Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance. Br. J. Pharmacol., 164 (7): 1753-66. [PMID:21488864]

* Kerr ID, Haider AJ, Gelissen IC. (2011) The ABCG family of membrane-associated transporters: you don't have to be big to be mighty. Br. J. Pharmacol., 164 (7): 1767-79. [PMID:21175590]

Linton KJ, Higgins CF. (2007) Structure and function of ABC transporters: the ATP switch provides flexible control. Pflugers Arch., 453 (5): 555-67. [PMID:16937116]

* López-Marqués RL, Poulsen LR, Bailly A, Geisler M, Pomorski TG, Palmgren MG. (2015) Structure and mechanism of ATP-dependent phospholipid transporters. Biochim. Biophys. Acta, 1850 (3): 461-475. [PMID:24746984]

* Miller DS. (2010) Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol. Sci., 31 (6): 246-54. [PMID:20417575]

* Nishi T, Kobayashi N, Hisano Y, Kawahara A, Yamaguchi A. (2014) Molecular and physiological functions of sphingosine 1-phosphate transporters. Biochim. Biophys. Acta, 1841 (5): 759-65. [PMID:23921254]

* Phillips MC. (2014) Molecular mechanisms of cellular cholesterol efflux. J. Biol. Chem., 289 (35): 24020-9. [PMID:25074931]

* Procko E, O'Mara ML, Bennett WF, Tieleman DP, Gaudet R. (2009) The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter. FASEB J., 23 (5): 1287-302. [PMID:19174475]

* Ravna AW, Sager G. (2009) Molecular modeling studies of ABC transporters involved in multidrug resistance. Mini Rev Med Chem, 9 (2): 186-93. [PMID:19200023]

* Rees DC, Johnson E, Lewinson O. (2009) ABC transporters: the power to change. Nat. Rev. Mol. Cell Biol., 10 (3): 218-27. [PMID:19234479]

Russel FG, Koenderink JB, Masereeuw R. (2008) Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules. Trends Pharmacol. Sci., 29 (4): 200-7. [PMID:18353444]

Schrickx JA, Fink-Gremmels J. (2008) Implications of ABC transporters on the disposition of typical veterinary medicinal products. Eur. J. Pharmacol., 585 (2-3): 510-9. [PMID:18417119]

* Seeger MA, van Veen HW. (2009) Molecular basis of multidrug transport by ABC transporters. Biochim. Biophys. Acta, 1794 (5): 725-37. [PMID:19135557]

Sharom FJ. (2008) ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics, 9 (1): 105-27. [PMID:18154452]

* Stacy AE, Jansson PJ, Richardson DR. (2013) Molecular pharmacology of ABCG2 and its role in chemoresistance. Mol. Pharmacol., 84 (5): 655-69. [PMID:24021215]

Szakács G, Váradi A, Ozvegy-Laczka C, Sarkadi B. (2008) The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discov. Today, 13 (9-10): 379-93. [PMID:18468555]

* Tarling EJ, de Aguiar Vallim TQ, Edwards PA. (2013) Role of ABC transporters in lipid transport and human disease. Trends Endocrinol. Metab., 24 (7): 342-50. [PMID:23415156]

Wanders RJ, Visser WF, van Roermund CW, Kemp S, Waterham HR. (2007) The peroxisomal ABC transporter family. Pflugers Arch., 453 (5): 719-34. [PMID:17039367]

* Westerterp M, Bochem AE, Yvan-Charvet L, Murphy AJ, Wang N, Tall AR. (2014) ATP-binding cassette transporters, atherosclerosis, and inflammation. Circ. Res., 114 (1): 157-70. [PMID:24385509]

* Wong K, Ma J, Rothnie A, Biggin PC, Kerr ID. (2014) Towards understanding promiscuity in multidrug efflux pumps. Trends Biochem. Sci., 39 (1): 8-16. [PMID:24316304]

References

NC-IUPHAR subcommittee and family contributors

How to cite this family page

Database page citation:

Mary Vore. ATP-binding cassette transporter family. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=136.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.