F-type and V-type ATPases | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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F-type and V-type ATPases

F-type and V-type ATPases C

Contents

Overview
Subfamilies
Further reading
How to cite this family page

Overview

The F-type (ATP synthase) and the V-type (vacuolar or vesicular proton pump) ATPases, although having distinct subcellular locations and roles, exhibit marked similarities in subunit structure and mechanism. They are both composed of a ‘soluble’ complex (termed F₁ or V₁) and a membrane complex (F_o or V_o). Within each ATPase complex, the two individual sectors appear to function as connected opposing rotary motors, coupling catalysis of ATP synthesis or hydrolysis to proton transport. Both the F-type and V-type ATPases have been assigned enzyme commission number E.C. 3.6.3.14

Subfamilies

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F-type ATPase C
V-type ATPase C

Further reading

* Key recommended reading is highlighted with an asterisk

* El Far O, Seagar M. (2011) A role for V-ATPase subunits in synaptic vesicle fusion?. J. Neurochem., 117 (4): 603-12. [PMID:21375531]

Huss M, Vitavska O, Albertmelcher A, Bockelmann S, Nardmann C, Tabke K, Tiburcy F, Wieczorek H. (2011) Vacuolar H(+)-ATPases: intra- and intermolecular interactions. Eur. J. Cell Biol., 90 (9): 688-95. [PMID:21640428]

* Junge W, Sielaff H, Engelbrecht S. (2009) Torque generation and elastic power transmission in the rotary F(O)F(1)-ATPase. Nature, 459 (7245): 364-70. [PMID:19458712]

* Krah A. (2015) Linking structural features from mitochondrial and bacterial F-type ATP synthases to their distinct mechanisms of ATPase inhibition. Prog. Biophys. Mol. Biol., [Epub ahead of print]. [PMID:26140992]

* Marshansky V, Rubinstein JL, Grüber G. (2014) Eukaryotic V-ATPase: novel structural findings and functional insights. Biochim. Biophys. Acta, 1837 (6): 857-79. [PMID:24508215]

* Martínez-Reyes I, Cuezva JM. (2014) The H(+)-ATP synthase: a gate to ROS-mediated cell death or cell survival. Biochim. Biophys. Acta, 1837 (7): 1099-112. [PMID:24685430]

* Mindell JA. (2012) Lysosomal acidification mechanisms. Annu. Rev. Physiol., 74: 69-86. [PMID:22335796]

* Nakamoto RK, Baylis Scanlon JA, Al-Shawi MK. (2008) The rotary mechanism of the ATP synthase. Arch. Biochem. Biophys., 476 (1): 43-50. [PMID:18515057]

* Nakanishi-Matsui M, Sekiya M, Nakamoto RK, Futai M. (2010) The mechanism of rotating proton pumping ATPases. Biochim. Biophys. Acta, 1797 (8): 1343-52. [PMID:20170625]

Navarro A, Boveris A. (2007) The mitochondrial energy transduction system and the aging process. Am. J. Physiol., Cell Physiol., 292 (2): C670-86. [PMID:17020935]

* Okuno D, Iino R, Noji H. (2011) Rotation and structure of FoF1-ATP synthase. J. Biochem., 149 (6): 655-64. [PMID:21524994]

Qi J, Wang Y, Forgac M. (2007) The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation. J. Bioenerg. Biomembr., 39 (5-6): 423-6. [PMID:18040762]

von Ballmoos C. (2007) Alternative proton binding mode in ATP synthases. J. Bioenerg. Biomembr., 39 (5-6): 441-5. [PMID:17965925]

* von Ballmoos C, Cook GM, Dimroth P. (2008) Unique rotary ATP synthase and its biological diversity. Annu Rev Biophys, 37: 43-64. [PMID:18573072]

* von Ballmoos C, Wiedenmann A, Dimroth P. (2009) Essentials for ATP synthesis by F1F0 ATP synthases. Annu. Rev. Biochem., 78: 649-72. [PMID:19489730]

How to cite this family page

Database page citation:

F-type and V-type ATPases. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=137.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.