The SLC22 family of transporters is mostly composed of non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role in drug disposition. The family may be divided into three subfamilies based on the nature of the substrate transported: organic cations (OCTs), organic anions (OATs) and organic zwiterrion/cations (OCTN). Membrane topology is predicted to contain 12 TM domains with intracellular termini, and an extended extracellular loop at TM 1/2.

Toggle GtoImmuPdb View Expand all nodesCollapse all nodes

* Key recommended reading is highlighted with an asterisk

Anderson CM, Thwaites DT. (2010) Hijacking solute carriers for proton-coupled drug transport. Physiology (Bethesda), 25 (6): 364-77. [PMID:21186281]

* Burckhardt G. (2012) Drug transport by Organic Anion Transporters (OATs). Pharmacol. Ther., 136 (1): 106-30. [PMID:22841915]

Duan P, You G. (2010) Short-term regulation of organic anion transporters. Pharmacol. Ther., 125 (1): 55-61. [PMID:19744520]

* Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol. Aspects Med., 34 (2-3): 413-35. [PMID:23506881]

Koepsell H, Endou H. (2004) The SLC22 drug transporter family. Pflugers Arch., 447 (5): 666-76. [PMID:12883891]

Koepsell H, Lips K, Volk C. (2007) Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm. Res., 24 (7): 1227-51. [PMID:17473959]

* König J, Müller F, Fromm MF. (2013) Transporters and drug-drug interactions: important determinants of drug disposition and effects. Pharmacol. Rev., 65 (3): 944-66. [PMID:23686349]

Miyazaki H, Sekine T, Endou H. (2004) The multispecific organic anion transporter family: properties and pharmacological significance. Trends Pharmacol. Sci., 25 (12): 654-62. [PMID:15530644]

* Motohashi H, Inui K. (2013) Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney. AAPS J, 15 (2): 581-8. [PMID:23435786]

Nigam SK, Bush KT, Bhatnagar V. (2007) Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol, 3 (8): 443-8. [PMID:17653123]

Saito H. (2010) Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol. Ther., 125 (1): 79-91. [PMID:19837111]

Sekine T, Miyazaki H, Endou H. (2006) Molecular physiology of renal organic anion transporters. Am. J. Physiol. Renal Physiol., 290 (2): F251-61. [PMID:16403838]

Zhou F, You G. (2007) Molecular insights into the structure-function relationship of organic anion transporters OATs. Pharm. Res., 24 (1): 28-36. [PMID:17103332]

Bruno Hagenbuch 4093 HLSIC; MS-1018 3901 Rainbow Blvd. Kansas City Kansas 66160