SLC25 family of mitochondrial transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters

SLC25 family of mitochondrial transporters C

Contents

Overview
Subfamilies
Further reading
How to cite this family page

Overview

Mitochondrial transporters are nuclear-encoded proteins, which convey solutes across the inner mitochondrial membrane. Topological modelling suggests homodimeric transporters, each with six TM segments and termini in the cytosol.

Subfamilies

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Mitochondrial di- and tri-carboxylic acid transporter subfamily C
Mitochondrial amino acid transporter subfamily C
Mitochondrial phosphate transporters C
Mitochondrial nucleotide transporter subfamily C
Mitochondrial uncoupling proteins C
Miscellaneous SLC25 mitochondrial transporters C

Further reading

* Key recommended reading is highlighted with an asterisk

* Cioffi F, Senese R, de Lange P, Goglia F, Lanni A, Lombardi A. (2009) Uncoupling proteins: a complex journey to function discovery. Biofactors, 35 (5): 417-28. [PMID:19626697]

* Clémençon B, Babot M, Trézéguet V. (2013) The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction. Mol. Aspects Med., 34 (2-3): 485-93. [PMID:23506884]

* Gnoni GV, Priore P, Geelen MJ, Siculella L. (2009) The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression. IUBMB Life, 61 (10): 987-94. [PMID:19787704]

* Gutiérrez-Aguilar M, Baines CP. (2013) Physiological and pathological roles of mitochondrial SLC25 carriers. Biochem. J., 454 (3): 371-86. [PMID:23988125]

Halestrap AP. (2009) What is the mitochondrial permeability transition pore?. J. Mol. Cell. Cardiol., 46 (6): 821-31. [PMID:19265700]

Jezek P, Jabůrek M, Garlid KD. (2010) Channel character of uncoupling protein-mediated transport. FEBS Lett., 584 (10): 2135-41. [PMID:20206627]

Leung AW, Halestrap AP. (2008) Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim. Biophys. Acta, 1777 (7-8): 946-52. [PMID:18407825]

* Monné M, Palmieri F. (2014) Antiporters of the mitochondrial carrier family. Curr Top Membr, 73: 289-320. [PMID:24745987]

* Palmieri F. (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch., 447 (5): 689-709. [PMID:14598172]

* Palmieri F. (2013) The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol. Aspects Med., 34 (2-3): 465-84. [PMID:23266187]

* Palmieri F. (2014) Mitochondrial transporters of the SLC25 family and associated diseases: a review. J. Inherit. Metab. Dis., 37 (4): 565-75. [PMID:24797559]

* Seifert EL, Ligeti E, Mayr JA, Sondheimer N, Hajnóczky G. (2015) The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease. Biochem. Biophys. Res. Commun., 464 (2): 369-75. [PMID:26091567]

How to cite this family page

Database page citation:

SLC25 family of mitochondrial transporters. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=147.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.