SLC26 family of anion exchangers
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Overview 
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Along with the SLC4 family, the SLC26 family acts to allow movement of monovalent and divalent anions across cell membranes. The predicted topology is of 8-14 TM domains with intracellular C- and N-termini, probably existing as dimers. Within the family, subgroups may be identified on the basis of functional differences.
Selective sulphate transporters
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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Sat-1
(SLC26A1)
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| Nomenclature |
Sat-1 |
| Systematic nomenclature |
SLC26A1 |
| Other names |
SAT-1,
EDM4,
SLC26A1,
canalicular sulfate transporter,
solute carrier family 26 member 1,
sulfate anion transporter,
sulfate anion transporter 1,
sulfate/carbonate antiporter,
Sat1
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| Genes |
SLC26A1 (Hs), Slc26a1 (Mm), Slc26a1 (Rn) |
| Ensembl ID |
ENSG00000145217 (Hs), ENSMUSG00000046959 (Mm), ENSRNOG00000000041 (Rn)
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| Substrates |
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| Stoichiometry |
SO42- (in) : anion (out)
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DTDST
(SLC26A2)
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Chloride/bicarbonate exchangers
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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DRA
(SLC26A3)
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| Nomenclature |
DRA |
| Systematic nomenclature |
SLC26A3 |
| Other names |
CLD,
congenital chloride diarrhea,
chloride anion exchanger,
down-regulated in adenoma,
solute carrier family 26, member 3
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| Genes |
SLC26A3 (Hs), Slc26a3 (Mm), Slc26a3 (Rn) |
| Ensembl ID |
ENSG00000091138 (Hs), ENSMUSG00000001225 (Mm), ENSRNOG00000006878 (Rn)
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| Substrates |
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| Stoichiometry |
2 Cl- (in) : 1 HCO3- (out) or 2 Cl- (in) : 1 OH- (out)
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Pendrin
(SLC26A4)
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| Nomenclature |
Pendrin |
| Systematic nomenclature |
SLC26A4 |
| Other names |
DFNB4,
PDS,
pendrin,
Pendred syndrome homolog,
Solute carrier family 26 member 4,
pendred syndrome homolog (human),
sodium-independent chloride/iodide transporter,
solute carrier family 26, member 4
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| Genes |
SLC26A4 (Hs), Slc26a4 (Mm), Slc26a4 (Rn) |
| Ensembl ID |
ENSG00000091137 (Hs), ENSMUSG00000020651 (Mm), ENSRNOG00000007314 (Rn)
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| Substrates |
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| Stoichiometry |
Unknown
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PAT-1
(SLC26A6)
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| Nomenclature |
PAT-1 |
| Systematic nomenclature |
SLC26A6 |
| Other names |
CFEX,
DKFZp586E1422,
pendrin-like protein 1,
pendrin L1,
sulfate anion transporter,
anion transporter 1,
LOC301010,
Slc26a6_predicted,
solute carrier family 26, member 6,
solute carrier family 26, member 6 (predicted),
Pat1
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| Genes |
SLC26A6 (Hs), Slc26a6 (Mm), Slc26a6 (Rn) |
| Ensembl ID |
ENSG00000225697 (Hs), ENSMUSG00000023259 (Mm), ENSRNOG00000020450 (Rn)
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| Substrates |
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| Stoichiometry |
1 SO42- (in) : 2 HCO3- (out) or 1 Cl- (in) : 2 HCO3- (out)
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Anion channels
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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SLC26A7
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| Systematic nomenclature |
SLC26A7 |
| Other names |
SUT2,
LOC297910,
Slc26a7_predicted,
anion exchange transporter,
solute carrier family 26, member 7,
solute carrier family 26, member 7 (predicted)
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| Genes |
SLC26A7 (Hs), Slc26a7 (Mm), Slc26a7 (Rn) |
| Ensembl ID |
ENSG00000147606 (Hs), ENSMUSG00000040569 (Mm), ENSRNOG00000006096 (Rn)
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Substrates
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nitrate >> Cl- = Br- = iodide > SO42- = L-glutamic acid
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| Functional characteristics |
Voltage- and time-independent current, linear I-V relationship [3]
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SLC26A9
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| Systematic nomenclature |
SLC26A9 |
| Other names |
anion transporter/exchanger-9,
LOC304784,
Slc26a9_predicted,
solute carrier family 26 member 9,
solute carrier family 26, member 9,
solute carrier family 26, member 9 (predicted)
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| Genes |
SLC26A9 (Hs), Slc26a9 (Mm), Slc26a9 (Rn) |
| Ensembl ID |
ENSG00000174502 (Hs), ENSMUSG00000042268 (Mm), ENSRNOG00000029514 (Rn)
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Substrates
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iodide > Br- > nitrate > Cl- > L-glutamic acid
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| Functional characteristics |
Voltage- and time-independent current, linear I-V relationship [2]
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| Comment |
SLC26A9 has been suggested to operate in two additional modes as a Cl--HCO3- exchanger and as a Na+-anion cotransporter [1].
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Other SLC26 anion exchangers
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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Prestin
(SLC26A5)
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| Nomenclature |
Prestin |
| Systematic nomenclature |
SLC26A5 |
| Other names |
PRES,
DFNB61,
prestin (motor protein),
deafness, neurosensory, autosomal recessive, 61,
prestin,
solute carrier family 26 member 5,
solute carrier family 26, member 5
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| Genes |
SLC26A5 (Hs), Slc26a5 (Mm), Slc26a5 (Rn) |
| Ensembl ID |
ENSG00000170615 (Hs), ENSMUSG00000029015 (Mm), ENSRNOG00000011616 (Rn)
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| Substrates |
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| Stoichiometry |
Unknown
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| Comment |
Prestin has been suggested to function as a molecular motor, rather than a transporter
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Tat1
(SLC26A8)
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| Nomenclature |
Tat1 |
| Systematic nomenclature |
SLC26A8 |
| Other names |
LOC309646,
Slc26a8_predicted,
solute carrier family 26, member 8,
solute carrier family 26, member 8 (predicted),
testis anion transporter 1
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| Genes |
SLC26A8 (Hs), Slc26a8 (Mm), Slc26a8 (Rn) |
| Ensembl ID |
ENSG00000112053 (Hs), ENSMUSG00000036196 (Mm), ENSRNOG00000042805 (Rn)
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| Substrates |
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| Stoichiometry |
Unknown
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SLC26A10
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| Systematic nomenclature |
SLC26A10 |
| Other names |
LOC366909,
RGD1564851,
RGD1564851_predicted,
Slc26a10,
similar to putative anion transporter,
similar to putative anion transporter (predicted),
solute carrier family 26 member 10,
solute carrier family 26, member 10
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| Genes |
SLC26A10 (Hs), Slc26a10 (Mm), Slc26a10 (Rn) |
| Ensembl ID |
ENSG00000135502 (Hs), ENSMUSG00000040441 (Mm), ENSRNOG00000029465 (Rn)
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| Stoichiometry |
Unknown
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| Comment |
SLC26A10 is a possible pseudogene
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SLC26A11
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| Systematic nomenclature |
SLC26A11 |
| Other names |
LOC360670,
Slc26a11_predicted,
sodium-independent sulfate anion transporter,
solute carrier family 26, member 11,
solute carrier family 26, member 11 (predicted)
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| Genes |
SLC26A11 (Hs), Slc26a11 (Mm), Slc26a11 (Rn) |
| Ensembl ID |
ENSG00000181045 (Hs), ENSMUSG00000039908 (Mm), ENSRNOG00000030537 (Rn)
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| Substrates |
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| Stoichiometry |
Unknown
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Further Reading Show »« Hide
Dorwart, MR; Shcheynikov, N; Yang, D; Muallem, S. (2008) The solute carrier 26 family of proteins in epithelial ion transport.
Physiology (Bethesda), 23: 104-14.
[PMID:18400693]
Kato, A; Romero, MF. (2011) Regulation of electroneutral NaCl absorption by the small intestine.
Annu. Rev. Physiol., 73: 261-81.
[PMID:21054167]
Mount, DB; Romero, MF. (2004) The SLC26 gene family of multifunctional anion exchangers.
Pflugers Arch., 447 (5): 710-21.
[PMID:12759755]
Ohana, E; Yang, D; Shcheynikov, N; Muallem, S. (2009) Diverse transport modes by the solute carrier 26 family of anion transporters.
J. Physiol. (Lond.), 587 (Pt 10): 2179-85.
[PMID:19015189]
References Show »« Hide
1. Chang, MH; Plata, C; Zandi-Nejad, K; Sindić, A; Sussman, CR; Mercado, A; Broumand, V; Raghuram, V; Mount, DB; Romero, MF. (2009) Slc26a9--anion exchanger, channel and Na+ transporter.
J. Membr. Biol., 228 (3): 125-40.
[PMID:19365592]
2. Dorwart, MR; Shcheynikov, N; Wang, Y; Stippec, S; Muallem, S. (2007) SLC26A9 is a Cl(-) channel regulated by the WNK kinases.
J. Physiol. (Lond.), 584 (Pt 1): 333-45.
[PMID:17673510]
3. Kim, KH; Shcheynikov, N; Wang, Y; Muallem, S. (2005) SLC26A7 is a Cl- channel regulated by intracellular pH.
J. Biol. Chem., 280 (8): 6463-70.
[PMID:15591059]
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