Nucleoside transporters are divided into two families, the sodium-dependent, concentrative solute carrier family 28 (SLC28) and the equilibrative, solute carrier family 29 (SLC29). The endogenous substrates are typically nucleosides, although some family members can also transport nucleobases and organic cations.

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* Key recommended reading is highlighted with an asterisk

* Boswell-Casteel RC, Hays FA. (2017) Equilibrative nucleoside transporters-A review. Nucleosides Nucleotides Nucleic Acids, 36 (1): 7-30. [PMID:27759477]

Cano-Soldado P, Pastor-Anglada M. (2012) Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition. Med Res Rev, 32 (2): 428-57. [PMID:21287570]

Dos Santos-Rodrigues A, Grañé-Boladeras N, Bicket A, Coe IR. (2014) Nucleoside transporters in the purinome. Neurochem. Int., 73: 229-37. [PMID:24704797]

King AE, Ackley MA, Cass CE, Young JD, Baldwin SA. (2006) Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol. Sci., 27 (8): 416-25. [PMID:16820221]

Pastor-Anglada M, Cano-Soldado P, Errasti-Murugarren E, Casado FJ. (2008) SLC28 genes and concentrative nucleoside transporter (CNT) proteins. Xenobiotica, 38 (7-8): 972-94. [PMID:18668436]

* Pastor-Anglada M, Pérez-Torras S. (2015) Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets. Front Pharmacol, 6: 13. [PMID:25713533]

* Young JD. (2016) The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey. Biochem. Soc. Trans., 44 (3): 869-76. [PMID:27284054]

* Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. (2013) The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects Med., 34 (2-3): 529-47. [PMID:23506887]

James R. Hammond Department of Pharmacology 970 Medical Sciences Bldg University of Alberta Edmonton, AB