- Advanced search
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The cell-surface Na+/K+-ATPase is an integral membrane protein which regulates the membrane potential of the cell by maintaining gradients of Na+ and K+ ions across the plasma membrane, also making a small, direct contribution to membrane potential, particularly in cardiac cells. For every molecule of ATP hydrolysed, the Na+/K+-ATPase extrudes three Na+ ions and imports two K+ ions. The active transporter is a heteromultimer with incompletely defined stoichiometry, possibly as tetramers of heterodimers, each consisting of one of four large, ten TM domain catalytic α subunits and one of three smaller, single TM domain glycoprotein β-subunits (see table). Additional protein partners known as FXYD proteins (e.g. FXYD2, P54710) appear to associate with and regulate the activity of the pump.
1. Bagrov AY, Shapiro JI, Fedorova OV. (2009) Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol. Rev., 61 (1): 9-38. [PMID:19325075]
2. De Munari S, Cerri A, Gobbini M, Almirante N, Banfi L, Carzana G, Ferrari P, Marazzi G, Micheletti R, Schiavone A et al.. (2003) Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds. J. Med. Chem., 46 (17): 3644-54. [PMID:12904068]
3. Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH et al.. (2009) Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur. J. Pharmacol., 622 (1-3): 7-14. [PMID:19751721]
4. Laursen M, Yatime L, Nissen P, Fedosova NU. (2013) Crystal structure of the high-affinity Na+K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site. Proc. Natl. Acad. Sci. U.S.A., 110 (27): 10958-63. [PMID:23776223]
5. Sweadner KJ. (1989) Isozymes of the Na+/K+-ATPase. Biochim. Biophys. Acta, 988 (2): 185-220. [PMID:2541792]
6. Templeton JF, Ling Y, Zeglam TH, LaBella FS. (1993) Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor. J. Med. Chem., 36 (1): 42-5. [PMID:8421289]
7. Woo AL, James PF, Lingrel JB. (2000) Sperm motility is dependent on a unique isoform of the Na,K-ATPase. J. Biol. Chem., 275 (27): 20693-9. [PMID:10764792]
Database page citation:
Na+/K+-ATPases. Accessed on 29/08/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=158.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol. 170: 1706–1796.