Adhesion Class GPCRs C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [1] containing a GPCR proteolytic site. The N-terminus often shares structural homology with proteins such as lectins and immunoglobulins, leading to the term adhesion GPCR [3,9]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [4].

Receptors

ADGRA1 C Show summary » More detailed page

ADGRA2 C Show summary » More detailed page

ADGRA3 C Show summary » More detailed page

ADGRB1 C Show summary » More detailed page

ADGRB2 C Show summary » More detailed page

ADGRB3 C Show summary » More detailed page

CELSR1 C Show summary » More detailed page

CELSR2 C Show summary » More detailed page

CELSR3 C Show summary » More detailed page

ADGRD1 C Show summary » More detailed page

ADGRD2 C Show summary » More detailed page

ADGRE1 C Show summary » More detailed page

ADGRE2 C Show summary » More detailed page

ADGRE3 C Show summary » More detailed page

ADGRE4P C Show summary » More detailed page

ADGRE5 C Show summary » More detailed page

ADGRF1 C Show summary » More detailed page

ADGRF2 C Show summary » More detailed page

ADGRF3 C Show summary » More detailed page

ADGRF4 C Show summary » More detailed page

ADGRF5 C Show summary » More detailed page

ADGRG1 C Show summary » More detailed page

ADGRG2 C Show summary » More detailed page

ADGRG3 C Show summary » More detailed page

ADGRG4 C Show summary » More detailed page

ADGRG5 C Show summary » More detailed page

ADGRG6 C Show summary » More detailed page

ADGRG7 C Show summary » More detailed page

ADGRL1 C Show summary » More detailed page

ADGRL2 C Show summary » More detailed page

ADGRL3 C Show summary » More detailed page

ADGRL4 C Show summary » More detailed page

ADGRV1 C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Demet Arac-Ozkan, Gabriela Aust, Tom I. Bonner, Heike Cappallo-Obermann, Caroline Formstone, Jörg Hamann, Breanne Harty, Henrike Heyne, Christiane Kirchhoff, Barbara Knapp, Arunkumar Krishnan, Tobias Langenhan, Diana Le Duc, Hsi-Hsien Lin, David C. Martinelli, Kelly Monk, Xianhua Piao, Simone Prömel, Helgi Schiöth, Torsten Schöneberg, Kathleen Singer, Martin Stacey, Yuri Ushkaryov, Uwe Wolfrum, Lei Xu. Adhesion Class GPCRs. Accessed on 26/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=17.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.