Adhesion Class GPCRs | G protein-coupled receptors | IUPHAR/BPS Guide to PHARMACOLOGY

Home
Targets
G protein-coupled receptors
Adhesion Class GPCRs

Adhesion Class GPCRs C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF

Overview

Show »« Hide More detailed introduction

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [1] containing a GPCR proteolytic site. The N-terminus often shares structural homology with proteins such as lectins and immunoglobulins, leading to the term adhesion GPCR [3,9]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [4].

Receptors

ADGRA1 C Show summary »« Hide summary More detailed page

ADGRA2 C Show summary »« Hide summary More detailed page

ADGRA3 C Show summary »« Hide summary More detailed page

ADGRB1 C Show summary »« Hide summary More detailed page

ADGRB2 C Show summary »« Hide summary More detailed page

ADGRB3 C Show summary »« Hide summary More detailed page

CELSR1 C Show summary »« Hide summary More detailed page

CELSR2 C Show summary »« Hide summary More detailed page

Target Id	179
Nomenclature	CELSR2
Previous and unofficial names	ADGRC2 (adhesion G protein-coupled receptor C2) \| MEGF3 \| multiple epidermal growth factor-like domains 3
Genes	CELSR2 (Hs), Celsr2 (Mm), Celsr2 (Rn)
Ensembl ID	ENSG00000143126 (Hs), ENSMUSG00000068740 (Mm), ENSRNOG00000020058 (Rn)
UniProtKB AC	Q9HCU4 (Hs), Q9R0M0 (Mm), Q9QYP2 (Rn)
Principal transduction	-

CELSR3 C Show summary »« Hide summary More detailed page

Target Id	180
Nomenclature	CELSR3
Previous and unofficial names	ADGRC3 (adhesion G protein-coupled receptor C3) \| MEGF2 \| multiple epidermal growth factor-like domains 2
Genes	CELSR3 (Hs), Celsr3 (Mm), Celsr3 (Rn)
Ensembl ID	ENSG00000008300 (Hs), ENSMUSG00000023473 (Mm), ENSRNOG00000034005 (Rn)
UniProtKB AC	Q9NYQ7 (Hs), Q91ZI0 (Mm), O88278 (Rn)
Principal transduction	-

ADGRD1 C Show summary »« Hide summary More detailed page

ADGRD2 C Show summary »« Hide summary More detailed page

Target Id	204
Nomenclature	ADGRD2
Previous and unofficial names	GPR144 (G protein-coupled receptor 144)
Genes	ADGRD2 (Hs), Adgrd2-ps (Mm)
Ensembl ID	ENSG00000180264 (Hs), ENSMUSG00000083722 (Mm)
UniProtKB AC	Q7Z7M1 (Hs)
Principal transduction	-

ADGRE1 C Show summary »« Hide summary More detailed page

ADGRE2 C Show summary »« Hide summary More detailed page

Target Id	183
Nomenclature	ADGRE2
Previous and unofficial names	EMR2 (EGF-like module-containing, mucin-like, hormone receptor-like 2) \| CD312 (cluster of differentiation 312)
Genes	ADGRE2 (Hs)
Ensembl ID	ENSG00000127507 (Hs)
UniProtKB AC	Q9UHX3 (Hs)
Principal transduction	-
Comment	A mutation destabilizing the GAIN domain sensitizes mast cells to IgE-independent vibration-induced degranulation [2].

ADGRE3 C Show summary »« Hide summary More detailed page

Target Id	184
Nomenclature	ADGRE3
Previous and unofficial names	EMR3 (EGF-like module-containing, mucin-like, hormone receptor-like 3)
Genes	ADGRE3 (Hs)
Ensembl ID	ENSG00000131355 (Hs)
UniProtKB AC	Q9BY15 (Hs)
Principal transduction	-

ADGRE4P C Show summary »« Hide summary More detailed page

Target Id	185
Nomenclature	ADGRE4P
Previous and unofficial names	FIRE (F4/80-like-receptor) \| EMR4 (EGF-like module-containing mucin-like hormone receptor-like 4) \| GPR127 \| G protein-coupled receptor 127
Genes	ADGRE4P (Hs), Adgre4 (Mm), Adgre4 (Rn)
Ensembl ID	ENSG00000186629 (Hs), ENSMUSG00000032915 (Mm), ENSRNOG00000050325 (Rn)
UniProtKB AC	Q86SQ3 (Hs), Q91ZE5 (Mm), Q5Y4N7 (Rn)
Principal transduction	-

ADGRE5 C Show summary »« Hide summary More detailed page

ADGRF1 C Show summary »« Hide summary More detailed page

ADGRF2 C Show summary »« Hide summary More detailed page

ADGRF3 C Show summary »« Hide summary More detailed page

ADGRF4 C Show summary »« Hide summary More detailed page

ADGRF5 C Show summary »« Hide summary More detailed page

ADGRG1 C Show summary »« Hide summary More detailed page

Target Id	186
Nomenclature	ADGRG1
Previous and unofficial names	BFPP \| GPR56 (G-protein coupled receptor 56) \| Cyt28
Genes	ADGRG1 (Hs), Adgrg1 (Mm), Adgrg1 (Rn)
Ensembl ID	ENSG00000205336 (Hs), ENSMUSG00000031785 (Mm), ENSRNOG00000014963 (Rn)
UniProtKB AC	Q9Y653 (Hs), Q8K209 (Mm), Q8K3V3 (Rn)
Principal transduction	-
Comment	Reported to bind tissue transglutaminase 2 [8] and collagen, which activates the G_12/13 pathway [6].

ADGRG2 C Show summary »« Hide summary More detailed page

ADGRG3 C Show summary »« Hide summary More detailed page

ADGRG4 C Show summary »« Hide summary More detailed page

ADGRG5 C Show summary »« Hide summary More detailed page

ADGRG6 C Show summary »« Hide summary More detailed page

Target Id	200
Nomenclature	ADGRG6
Previous and unofficial names	GPR126 (G protein-coupled receptor 126) \| developmentally regulated GPCR \| vascular inducible GPCR
Genes	ADGRG6 (Hs), Adgrg6 (Mm), Adgrg6 (Rn)
Ensembl ID	ENSG00000112414 (Hs), ENSMUSG00000039116 (Mm), ENSRNOG00000011411 (Rn)
UniProtKB AC	Q86SQ4 (Hs), Q6F3F9 (Mm)
Principal transduction	-

ADGRG7 C Show summary »« Hide summary More detailed page

ADGRL1 C Show summary »« Hide summary More detailed page

Target Id	206
Nomenclature	ADGRL1
Previous and unofficial names	LPHN1 (latrophilin 1) \| LEC1 (lectomedin-2) \| CIRL1 (calcium-independent alpha-latrotoxin 1) \| CL1 (CIRL/latrophilin 1)
Genes	ADGRL1 (Hs), Adgrl1 (Mm), Adgrl1 (Rn)
Ensembl ID	ENSG00000072071 (Hs), ENSMUSG00000013033 (Mm), ENSRNOG00000029134 (Rn)
UniProtKB AC	O94910 (Hs), Q80TR1 (Mm), O88917 (Rn)
Principal transduction	-

ADGRL2 C Show summary »« Hide summary More detailed page

Target Id	207
Nomenclature	ADGRL2
Previous and unofficial names	LPHN2 (latrophilin 2) \| LPHH1 (latrophilin homologue in humans 1) \| LEC1 (lectomedin-1) \| CIRL2 (calcium-independent receptor of alpha-latrotoxin 2)
Genes	ADGRL2 (Hs), Adgrl2 (Mm), Adgrl2 (Rn)
Ensembl ID	ENSG00000117114 (Hs), ENSMUSG00000028184 (Mm), ENSRNOG00000032660 (Rn)
UniProtKB AC	O95490 (Hs), Q8JZZ7 (Mm), O88923 (Rn)
Principal transduction	-

ADGRL3 C Show summary »« Hide summary More detailed page

Target Id	208
Nomenclature	ADGRL3
Previous and unofficial names	LPHN3 (latrophilin 3) \| CIRL3 (calcium-independent receptor of alpha-latrotoxin 3) \| LEC3 (Lectomedin-3) \| CL3 (CIRL/latrophilin 3)
Genes	ADGRL3 (Hs), Adgrl3 (Mm), Adgrl3 (Rn)
Ensembl ID	ENSG00000150471 (Hs), ENSMUSG00000037605 (Mm), ENSRNOG00000030149 (Rn)
UniProtKB AC	Q9HAR2 (Hs), Q80TS3 (Mm), Q9Z173 (Rn)
Principal transduction	-

ADGRL4 C Show summary »« Hide summary More detailed page

Target Id	181
Nomenclature	ADGRL4
Previous and unofficial names	ETL \| EGF-TM7-latrophilin-related protein \| ELTD1 \| EGF, latrophilin seven transmembrane domain containing 1
Genes	ADGRL4 (Hs), Adgrl4 (Mm), Adgrl4 (Rn)
Ensembl ID	ENSG00000162618 (Hs), ENSMUSG00000039167 (Mm), ENSRNOG00000033940 (Rn)
UniProtKB AC	Q9HBW9 (Hs), Q923X1 (Mm), Q9ESC1 (Rn)
Principal transduction	-

ADGRV1 C Show summary »« Hide summary More detailed page

Target Id	189
Nomenclature	ADGRV1
Previous and unofficial names	FEB4 \| MASS1 \| USH2C \| VLGR1 \| very large G protein-coupled receptor 1 \| GPR98 (G protein-coupled receptor 98)
Genes	ADGRV1 (Hs), Adgrv1 (Mm), Adgrv1 (Rn)
Ensembl ID	ENSG00000164199 (Hs), ENSMUSG00000069170 (Mm), ENSRNOG00000046496 (Rn)
UniProtKB AC	Q8WXG9 (Hs), Q8VHN7 (Mm)
Principal transduction	-
Comment	Loss-of-function mutations are associated with Usher syndrome, a sensory deficit disorder [5].

References

Show »« Hide

1. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT. (2012) A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J., 31 (6): 1364-78. [PMID:22333914]

2. Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CC, Satorius CL et al.. (2016) Vibratory Urticaria Associated with a Missense Variant in ADGRE2. N. Engl. J. Med., 374 (7): 656-63. [PMID:26841242]

3. Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol, 63: 1256-1272. [PMID:12761335]

4. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B et al.. (2015) International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol. Rev., 67 (2): 338-67. [PMID:25713288]

5. Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Roman AJ, Gardner LM, Prosser HM, Mishra M, Bech-Hansen NT, Herrera W, Schwartz SB, Liu XZ, Kimberling WJ, Steel KP, Williams DS. (2008) Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism. Hum. Mol. Genet., 17 (15): 2405-15. [PMID:18463160]

6. Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X. (2011) G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc. Natl. Acad. Sci. U.S.A., 108 (31): 12925-30. [PMID:21768377]

7. Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS. (2007) BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature, 450 (7168): 430-4. [PMID:17960134]

8. Xu L, Begum S, Hearn JD, Hynes RO. (2006) GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci U S A, 103: 9023-9028. [PMID:16757564]

9. Yona S, Lin HH, Siu WO, Gordon S, Stacey M. (2008) Adhesion-GPCRs: emerging roles for novel receptors. Trends Biochem. Sci., 33 (10): 491-500. [PMID:18789697]

NC-IUPHAR subcommittee and family contributors

Show »« Hide

Demet Arac-Ozkan
Department of Biochemistry and Molecular Biology
University of Chicago
929 E. 57th Street
GCIS W210
Chicago, IL 60637
USA

Gabriela Aust
Department of Surgery
University of Leipzig
Liebigstr. 20
04103 Leipzig
Germany

Tom I. Bonner
Special Volunteer
Office of Science Director
NIMH
Bethesda,br/>MD

Heike Cappallo-Obermann
University Hospital Hamburg-Eppendorf
Department of Andrology
Martinistrasse 52
20246 Hamburg
Germany

Caroline Formstone
MRC Centre for Developmental Neurobiology
King's College London
New Hunt's House, 4th Floor
Guy's Hospital Campus
London SE1 1UL
UK

Jörg Hamann
Academic Medical Center
University of Amsterdam
Meibergdreef 9
1105AZ Amsterdam
The Netherlands

Breanne Harty
Washington University School of Medicine
Dept of Developmental Biology
660 S. Euclid Ave
St. Louis
MO 63130
USA

Henrike Heyne
Institute of Biochemistry,
Medical Faculty
University of Leipzig
Johannisallee 30
04103 Leipzig
Germany

Christiane Kirchhoff
University Hospital Hamburg-Eppendorf
Department of Andrology
Martinistrasse 52
20246 Hamburg
Germany

Barbara Knapp
Johannes-Gutenberg Universitaet Mainz
Institut fuer Zoologie, Abt. I - AG Wolfrum
Muellerweg 6
D-55099 Mainz
Germany

Arunkumar Krishnan
Department of Neuroscience
Biomedical Center
Box 593
75 124 Uppsala
Sweden

Tobias Langenhan
Division of General Biochemistry
Rudolf-Schönheimer-Institute of Biochemistry
University of Leipzig
Johannisallee 3004103
Leipzig
Germany

Diana Le Duc
Institute of Biochemistry
Medical Faculty
University of Leipzig
Johannisallee 30
04103 Leipzig
Germany

Hsi-Hsien Lin
Department of Microbiology and Immunology
College of Medicine
Chang Gung University
259 Wen-Hwa 1st Road
Kwei-Shan
Tao-Yuan
Taiwan

David C. Martinelli
265 Campus Drive
Stanford
California 94305
USA

Kelly Monk
Washington University School of Medicine
Dept of Developmental Biology
660 S. Euclid Ave
St. Louis
MO 63130
USA

Xianhua Piao
Boston Children's Hospital,
Department of Newborn Medicine
300 Longwood Avenue,
Boston,
MA 02115, USA

Simone Prömel
Institute of Biochemistry
Medical Faculty
University of Leipzig
Johannisallee 30
04103 Leipzig
Germany

Helgi Schiöth
Dept. of Neuroscience
Biomedical Centre
Uppsala University
Uppsala
Sweden

Torsten Schöneberg
Institute of Biochemistry
Medical Faculty
University of Leipzig
Johannisallee 30
04103 Leipzig
Germany

Kathleen Singer
Boston Children's Hospital,
Department of GI/Nutrition,
300 Longwood Avenue,
Boston,
MA 02115, USA

Martin Stacey
Institute of Molecular and Cellular Biology
Garstang 8.54
University of Leeds
Leeds, LS2 9JT
UK

Yuri Ushkaryov
Medway School of Pharmacy
University of Kent
Central Avenue
Anson Building
Chatham Maritime
ME4 4TB
UK

Uwe Wolfrum
Johannes-Gutenberg Universitaet Mainz
Institut fuer Zoologie, Abt. I - AG Wolfrum
Muellerweg 6
D-55099 Mainz
Germany

Lei Xu
601 Elmwood Ave.,
Department of Biomedical Genetics,
University of Rochester Medical Center,
Rochester,
NY 14642, USA

How to cite this family page

Database page citation:

Demet Arac-Ozkan, Gabriela Aust, Tom I. Bonner, Heike Cappallo-Obermann, Caroline Formstone, Jörg Hamann, Breanne Harty, Henrike Heyne, Christiane Kirchhoff, Barbara Knapp, Arunkumar Krishnan, Tobias Langenhan, Diana Le Duc, Hsi-Hsien Lin, David C. Martinelli, Kelly Monk, Xianhua Piao, Simone Prömel, Helgi Schiöth, Torsten Schöneberg, Kathleen Singer, Martin Stacey, Yuri Ushkaryov, Uwe Wolfrum, Lei Xu. Adhesion Class GPCRs. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=17.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.