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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Predicted to be 12 TM segment proteins, members of this family transport the reduced form of ascorbic acid (while the oxidized form may be handled by members of the SLC2 family (GLUT1/SLC2A1, GLUT3/SLC2A3 and GLUT4/SLC2A4). Phloretin is considered a non-selective inhibitor of these transporters, with an affinity in the micromolar range.
* Key recommended reading is highlighted with an asterisk
* Bürzle M, Suzuki Y, Ackermann D, Miyazaki H, Maeda N, Clémençon B, Burrier R, Hediger MA. (2013) The sodium-dependent ascorbic acid transporter family SLC23. Mol. Aspects Med., 34 (2-3): 436-54. [PMID:23506882]
* May JM. (2011) The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C. Br. J. Pharmacol., 164 (7): 1793-801. [PMID:21418192]
Rivas CI, Zúñiga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC. (2008) Vitamin C transporters. J. Physiol. Biochem., 64 (4): 357-75. [PMID:19391462]
* Savini I, Rossi A, Pierro C, Avigliano L, Catani MV. (2008) SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids, 34 (3): 347-55. [PMID:17541511]
Takanaga H, Mackenzie B, Hediger MA. (2004) Sodium-dependent ascorbic acid transporter family SLC23. Pflugers Arch., 447 (5): 677-82. [PMID:12845532]
1. MacDonald L, Thumser AE, Sharp P. (2002) Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line. Br. J. Nutr., 87 (2): 97-100. [PMID:11895172]
2. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA. (1999) A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature, 399 (6731): 70-5. [PMID:10331392]
3. Yamamoto S, Inoue K, Murata T, Kamigaso S, Yasujima T, Maeda JY, Yoshida Y, Ohta KY, Yuasa H. (2010) Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals. J. Biol. Chem., 285 (9): 6522-31. [PMID:20042597]
Database page citation:
James May. SLC23 family of ascorbic acid transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=201.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.