SLC35 family of nucleotide sugar transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Glycoprotein formation in the Golgi and endoplasmic reticulum relies on the accumulation of nucleotide-conjugated sugars via the SLC35 family of transporters. These transporters have a predicted topology of 10 TM domains, with cytoplasmic termini, and function as exchangers, swopping nucleoside monophosphates for the corresponding nucleoside diphosphate conjugated sugar. Five subfamilies of transporters have been identified on the basis of sequence similarity, namely SLC35A1, SLC35A2, SLC35A3, SLC35A4 and SLC35A5; SLC35B1, SLC35B2, SLC35B3 and SLC35B4; SLC35C1 and SLC35C2; SLC35D1, SL35D1, SLC35D2 and SLC35D3, and the subfamily of orphan SLC35 transporters, SLC35E1-4 and SLC35F1-5.

Transporters

CMP-sialic acid transporter / SLC35A1 Show summary »

UDP-galactose transporter / SLC35A2 Show summary »

UDP-N-acetylglucosamine transporter / SLC35A3 Show summary »

MGC2541 / SLC35A4 Show summary »

FLJ11130 / SLC35A5 Show summary »

UGTREL1 / SLC35B1 Show summary »

PAPS transporter 1 / SLC35B2 Show summary »

PAPS transporter 2 / SLC35B3 Show summary »

YEA / SLC35B4 Show summary »

GDP-Fucose transporter / SLC35C1 Show summary »

OVCOV1 / SLC35C2 Show summary »

UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter / SLC35D1 Show summary »

HFRC1 / SLC35D2 Show summary »

FRCL1 / SLC35D3 Show summary »

SLC35E1 Show summary »

SLC35E2 Show summary »

solute carrier family 35, member E2B / SLC35E2B Show summary »

SLC35E3 Show summary »

SLC35E4 Show summary »

SLC35F1 Show summary »

SLC35F2 Show summary »

SLC35F3 Show summary »

SLC35F4 Show summary »

SLC35F5 Show summary »

solute carrier family 35, member F6 / SLC35F6 Show summary »

solute carrier family 35, member G1 / SLC35G1 Show summary »

solute carrier family 35, member G2 / SLC35G2 Show summary »

solute carrier family 35, member G3 / SLC35G3 Show summary »

solute carrier family 35, member G4 / SLC35G4 Show summary »

solute carrier family 35, member G5 / SLC35G5 Show summary »

solute carrier family 35, member G6 / SLC35G6 Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC35 family of nucleotide sugar transporters. Accessed on 20/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=222.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol. 170: 1706–1796.