Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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Zinc transporter 1
(SLC39A1)
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| Nomenclature |
Zinc transporter 1 |
| Systematic nomenclature |
SLC39A1 |
| Common abbreviation |
ZIP1 |
| Other names |
Zinc/iron-regulated transporter-like; ZIRTL,
ZRT- and IRT-like protein 1,
ZIRTL,
ZIP1,
zinc/iron regulated transporter-like,
LOC361986,
Slc39a1_predicted,
solute carrier family 39 (zinc transporter), member 1,
solute carrier family 39 (zinc transporter), member 1 (predicted),
zinc transporter ZIP1
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| Genes |
SLC39A1 (Hs), Slc39a1 (Mm), Slc39a1 (Rn) |
| Ensembl ID |
ENSG00000143570 (Hs), ENSMUSG00000052310 (Mm), ENSRNOG00000016344 (Rn)
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Zinc transporter 2
(SLC39A2)
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| Nomenclature |
Zinc transporter 2 |
| Systematic nomenclature |
SLC39A2 |
| Common abbreviation |
ZIP2 |
| Other names |
ZRT- and IRT-like protein 2,
ZIP2,
LOC305846,
Slc39a2_predicted,
solute carrier family 39 (zinc transporter), member 2,
solute carrier family 39 (zinc transporter), member 2 (predicted),
zinc transporter ZIP2
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| Genes |
SLC39A2 (Hs), Slc39a2 (Mm), Slc39a2 (Rn) |
| Ensembl ID |
ENSG00000165794 (Hs), ENSMUSG00000072572 (Mm), ENSRNOG00000010375 (Rn)
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Zinc transporter 3
(SLC39A3)
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| Nomenclature |
Zinc transporter 3 |
| Systematic nomenclature |
SLC39A3 |
| Common abbreviation |
ZIP3 |
| Other names |
ZRT- and IRT-like protein 3,
ZIP3,
LOC314637,
MGC105842,
Slc39a3_predicted,
ZIP-3,
solute carrier family 39 (zinc transporter), member 3 (predicted),
solute carrier family 39 member 3,
zinc transporter ZIP3
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| Genes |
SLC39A3 (Hs), Slc39a3 (Mm), Slc39a3 (Rn) |
| Ensembl ID |
ENSG00000141873 (Hs), ENSMUSG00000046822 (Mm), ENSRNOG00000019874 (Rn)
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Zinc transporter 4
(SLC39A4)
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| Nomenclature |
Zinc transporter 4 |
| Systematic nomenclature |
SLC39A4 |
| Common abbreviation |
ZIP4 |
| Other names |
ZRT- and IRT-like protein 4,
AEZ,
ZIP4,
AWMS2,
acrodermatitis enteropathica, zinc-deficiency type,
Slc39a4_predicted,
MGC156705,
LOC300051,
ZIP-4,
solute carrier family 39 (zinc transporter), member 4 (predicted),
solute carrier family 39 member 4,
zinc transporter ZIP4
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| Genes |
SLC39A4 (Hs), Slc39a4 (Mm), Slc39a4 (Rn) |
| Ensembl ID |
ENSG00000206288 (Hs), ENSMUSG00000063354 (Mm), ENSRNOG00000014314 (Rn)
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metal ion transporter 5
(SLC39A5)
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| Nomenclature |
metal ion transporter 5 |
| Systematic nomenclature |
SLC39A5 |
| Common abbreviation |
ZIP5 |
| Other names |
Metal ion transporter 5,
LOC362812,
Slc39a5_predicted,
solute carrier family 39 (metal ion transporter), member 5,
solute carrier family 39 (metal ion transporter), member 5 (predicted),
zinc transporter ZIP5,
Zip5
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| Genes |
SLC39A5 (Hs), Slc39a5 (Mm), Slc39a5 (Rn) |
| Ensembl ID |
ENSG00000139540 (Hs), ENSMUSG00000039878 (Mm), ENSRNOG00000033361 (Rn)
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Zinc transporter 6
(SLC39A6)
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| Nomenclature |
Zinc transporter 6 |
| Systematic nomenclature |
SLC39A6 |
| Common abbreviation |
ZIP6 |
| Other names |
LIV1,
LIV-1,
solute carrier family 39 (metal ion transporter), member 6,
LOC291733,
Slc39a6_predicted,
ZIP-6,
solute carrier family 39 (metal ion transporter), member 6 (predicted),
solute carrier family 39 member 6,
zinc transporter ZIP6,
zrt- and Irt-like protein 6,
Ermelin
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| Genes |
SLC39A6 (Hs), Slc39a6 (Mm), Slc39a6 (Rn) |
| Ensembl ID |
ENSG00000141424 (Hs), ENSMUSG00000024270 (Mm), ENSRNOG00000028703 (Rn)
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Zinc transporter 7
(SLC39A7)
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| Nomenclature |
Zinc transporter 7 |
| Systematic nomenclature |
SLC39A7 |
| Common abbreviation |
ZIP7 |
| Other names |
HKE4,
H2-KE4,
D6S2244E,
KE4,
RING5,
ZIP7,
HLA class II region expressed gene KE4,
MGC94153,
RT1-Ke4,
RT1-Ke4_mapped,
Rt1Ke4,
Histidine-rich membrane protein,
RT1 class I, locus Ke4,
RT1 class I, locus Ke4 (mapped),
RT1 region expressed gene KE4,
solute carrier family 39 (zinc transporter), member 7,
Ke-4,
H-2Ke4
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| Genes |
SLC39A7 (Hs), Slc39a7 (Mm), Slc39a7 (Rn) |
| Ensembl ID |
ENSG00000112473 (Hs), ENSMUSG00000024327 (Mm), ENSRNOG00000000465 (Rn)
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Zinc transporter 8
(SLC39A8)
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| Nomenclature |
Zinc transporter 8 |
| Systematic nomenclature |
SLC39A8 |
| Common abbreviation |
ZIP8 |
| Other names |
BIGM103,
solute carrier family 39 (metal ion transporter), member 8,
LOC295455,
MGC108852,
Slc39a8_predicted,
ZIP-8,
solute carrier family 39 (metal ion transporter), member 8 (predicted),
solute carrier family 39 member 8,
zinc transporter ZIP8,
zrt- and Irt-like protein 8,
ZIP8
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| Genes |
SLC39A8 (Hs), Slc39a8 (Mm), Slc39a8 (Rn) |
| Ensembl ID |
ENSG00000138821 (Hs), ENSMUSG00000053897 (Mm), ENSRNOG00000012508 (Rn)
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| Substrates |
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| Stoichiometry |
1 Zn2+ (in) : 2 HCO3- (in) [3]
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Zinc transporter 9
(SLC39A9)
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| Nomenclature |
Zinc transporter 9 |
| Systematic nomenclature |
SLC39A9 |
| Common abbreviation |
ZIP9 |
| Other names |
FLJ11274,
LOC314275,
MGC125246,
Slc39a9_predicted,
ZIP-9,
solute carrier family 39 (zinc transporter), member 9 (predicted),
solute carrier family 39 member 9,
zinc transporter ZIP9,
zrt- and Irt-like protein 9
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| Genes |
SLC39A9 (Hs), Slc39a9 (Mm), Slc39a9 (Rn) |
| Ensembl ID |
ENSG00000029364 (Hs), ENSMUSG00000048833 (Mm), ENSRNOG00000005052 (Rn)
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Zinc transporter 10
(SLC39A10)
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| Nomenclature |
Zinc transporter 10 |
| Systematic nomenclature |
SLC39A10 |
| Common abbreviation |
ZIP10 |
| Other names |
KIAA1265,
FLJ90515,
DKFZp564L2123,
solute carrier family 39 (metal ion transporter), member 10,
LOC363229,
Slc39a10_predicted,
solute carrier family 39 (zinc transporter), member 10,
solute carrier family 39 (zinc transporter), member 10 (predicted),
zinc transporter ZIP10
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| Genes |
SLC39A10 (Hs), Slc39a10 (Mm), Slc39a10 (Rn) |
| Ensembl ID |
ENSG00000196950 (Hs), ENSMUSG00000025986 (Mm), ENSRNOG00000011677 (Rn)
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Zinc transporter 11
(SLC39A11)
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| Nomenclature |
Zinc transporter 11 |
| Systematic nomenclature |
SLC39A11 |
| Common abbreviation |
ZIP11 |
| Other names |
Metal ion transporter 11,
C17orf26,
chromosome 17 open reading frame 26,
LOC287796,
Slc39a11_predicted,
ZIP-11,
solute carrier family 39 (metal ion transporter), member 11 (predicted),
solute carrier family 39 member 11,
zinc transporter ZIP11,
zrt- and Irt-like protein 11
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| Genes |
SLC39A11 (Hs), Slc39a11 (Mm), Slc39a11 (Rn) |
| Ensembl ID |
ENSG00000133195 (Hs), ENSMUSG00000041654 (Mm), ENSRNOG00000031213 (Rn)
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Zinc transporter 12
(SLC39A12)
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| Nomenclature |
Zinc transporter 12 |
| Systematic nomenclature |
SLC39A12 |
| Common abbreviation |
ZIP12 |
| Other names |
FLJ30499,
solute carrier family 39 (metal ion transporter), member 12,
LOC291328,
Slc39a12_predicted,
solute carrier family 39 (zinc transporter), member 12,
solute carrier family 39 (zinc transporter), member 12 (predicted),
zinc transporter ZIP12,
LOC277468
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| Genes |
SLC39A12 (Hs), Slc39a12 (Mm), Slc39a12 (Rn) |
| Ensembl ID |
ENSG00000148482 (Hs), ENSMUSG00000036949 (Mm), ENSRNOG00000025639 (Rn)
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Zinc transporter 13
(SLC39A13)
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| Nomenclature |
Zinc transporter 13 |
| Systematic nomenclature |
SLC39A13 |
| Common abbreviation |
ZIP13 |
| Other names |
FLJ25785,
solute carrier family 39 (metal ion transporter), member 13,
LOC295928,
MGC124816,
Slc39a13_predicted,
ZIP-13,
solute carrier family 39 (zinc transporter), member 13 (predicted),
solute carrier family 39 member 13,
zinc transporter ZIP13,
zrt- and Irt-like protein 13,
ZIP13
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| Genes |
SLC39A13 (Hs), Slc39a13 (Mm), Slc39a13 (Rn) |
| Ensembl ID |
ENSG00000165915 (Hs), ENSMUSG00000002105 (Mm), ENSRNOG00000011981 (Rn)
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Zinc transporter 14
(SLC39A14)
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| Nomenclature |
Zinc transporter 14 |
| Systematic nomenclature |
SLC39A14 |
| Common abbreviation |
ZIP14 |
| Other names |
KIAA0062,
NET34,
ZIP14,
solute carrier family 39 (metal ion transporter), member 14,
LOC306009,
Slc39a14_predicted,
solute carrier family 39 (zinc transporter), member 14,
solute carrier family 39 (zinc transporter), member 14 (predicted),
zinc transporter ZIP14
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| Genes |
SLC39A14 (Hs), Slc39a14 (Mm), Slc39a14 (Rn) |
| Ensembl ID |
ENSG00000104635 (Hs), ENSMUSG00000022094 (Mm), ENSRNOG00000009832 (Rn)
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| Substrates |
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Eide, DJ. (2004) The SLC39 family of metal ion transporters.
Pflugers Arch., 447 (5): 796-800.
[PMID:12748861]
Himeno, S; Yanagiya, T; Fujishiro, H. (2009) The role of zinc transporters in cadmium and manganese transport in mammalian cells.
Biochimie, 91 (10): 1218-22.
[PMID:19375483]
Rungby, J. (2010) Zinc, zinc transporters and diabetes.
Diabetologia, 53 (8): 1549-51.
[PMID:20490449]
Thévenod, F. (2010) Catch me if you can! Novel aspects of cadmium transport in mammalian cells.
Biometals, 23 (5): 857-75.
[PMID:20204475]
1. Dalton, TP; He, L; Wang, B; Miller, ML; Jin, L; Stringer, KF; Chang, X; Baxter, CS; Nebert, DW. (2005) Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis.
Proc. Natl. Acad. Sci. U.S.A., 102 (9): 3401-6.
[PMID:15722412]
2. Girijashanker, K; He, L; Soleimani, M; Reed, JM; Li, H; Liu, Z; Wang, B; Dalton, TP; Nebert, DW. (2008) Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter.
Mol. Pharmacol., 73 (5): 1413-23.
[PMID:18270315]
3. Liu, Z; Li, H; Soleimani, M; Girijashanker, K; Reed, JM; He, L; Dalton, TP; Nebert, DW. (2008) Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.
Biochem. Biophys. Res. Commun., 365 (4): 814-20.
[PMID:18037372]
4. Liuzzi, JP; Aydemir, F; Nam, H; Knutson, MD; Cousins, RJ. (2006) Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.
Proc. Natl. Acad. Sci. U.S.A., 103 (37): 13612-7.
[PMID:16950869]
@GuidetoPHARM 
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Zinc fluxes may be monitored through the use of radioisotopic Zn-65 or the fluorescent dye FluoZin 3.
The bicarbonate transport inhibitor DIDS has been reported to inhibit cation accumulation through ZIP14 [2].