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Based on the proptypical member of this family, PCFT, this family are proton-driven transporters with 11 TM segments. SLC46A1 has been described to act as an intestinal proton-coupled high-affinity folic acid transporter , with lower affinity for heme. folic acid accumulation is independent of Na+ or K+ ion concentrations, but driven by extracellular protons with an as yet undefined stoichiometry.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Proton-coupled folate transporter (SLC46A1) Show »
Thymic stromal co-transporter (SLC46A2) Show »
SLC46A3 Show »
Further Reading Show »
Anderson, CM; Thwaites, DT. (2010) Hijacking solute carriers for proton-coupled drug transport. Physiology (Bethesda), 25 (6): 364-77. [PMID:21186281]
Krishnamurthy, P; Xie, T; Schuetz, JD. (2007) The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol. Ther., 114 (3): 345-58. [PMID:17368550]
Latunde-Dada, GO; Simpson, RJ; McKie, AT. (2006) Recent advances in mammalian haem transport. Trends Biochem. Sci., 31 (3): 182-8. [PMID:16487711]
Thwaites, DT; Anderson, CM. (2007) H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp. Physiol., 92 (4): 603-19. [PMID:17468205]
Wolf, G. (2007) Identification of proton-coupled high-affinity human intestinal folate transporter mutated in human hereditary familial folate malabsorption. Nutr. Rev., 65 (12 Pt 1): 554-7. [PMID:18236695]
Yuasa, H; Inoue, K; Hayashi, Y. (2009) Molecular and functional characteristics of proton-coupled folate transporter. J Pharm Sci, 98 (5): 1608-16. [PMID:18823045]
References Show »
1. Nakai, Y; Inoue, K; Abe, N; Hatakeyama, M; Ohta, KY; Otagiri, M; Hayashi, Y; Yuasa, H. (2007) Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J. Pharmacol. Exp. Ther., 322 (2): 469-76. [PMID:17475902]
2. Qiu, A; Jansen, M; Sakaris, A; Min, SH; Chattopadhyay, S; Tsai, E; Sandoval, C; Zhao, R; Akabas, MH; Goldman, ID. (2006) Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell, 127 (5): 917-28. [PMID:17129779]