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Although identified as a haem transporter , subsequent evidence suggests this 4TM-containing protein associates with the V-ATPase in lysosomes for heme degradation . As yet, this transporter awaits characterization.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Heme transporter (SLC48A1) Show »
References Show »
1. O'Callaghan, KM; Ayllon, V; O'Keeffe, J; Wang, Y; Cox, OT; Loughran, G; Forgac, M; O'Connor, R. (2010) Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. J. Biol. Chem., 285 (1): 381-91. [PMID:19875448]
2. Rajagopal, A; Rao, AU; Amigo, J; Tian, M; Upadhyay, SK; Hall, C; Uhm, S; Mathew, MK; Fleming, MD; Paw, BH; et al.. (2008) Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature, 453 (7198): 1127-31. [PMID:18418376]