SLC48 haem transporter
Overview 
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Although identified as a haem transporter [2], subsequent evidence suggests this 4TM-containing protein associates with the V-ATPase in lysosomes for heme degradation [1]. As yet, this transporter awaits characterization.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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Heme transporter
(SLC48A1)
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| Nomenclature |
Heme transporter |
| Systematic nomenclature |
SLC48A1 |
| Common abbreviation |
HRG1 |
| Other names |
Heme-responsive gene 1,
hHRG-1,
FLJ20489,
HRG1,
HRG-1,
LOC300191,
MGC125237,
Heme transporter HRG1,
Heme-responsive gene 1 protein homolog,
similar to RIKEN cDNA 4930570C03,
solute carrier family 48 member 1
|
| Genes |
SLC48A1 (Hs), Slc48a1 (Mm), Slc48a1 (Rn) |
| Ensembl ID |
ENSG00000211584 (Hs), ENSMUSG00000081534 (Mm), ENSRNOG00000008192 (Rn)
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References Show »« Hide
1. O'Callaghan, KM; Ayllon, V; O'Keeffe, J; Wang, Y; Cox, OT; Loughran, G; Forgac, M; O'Connor, R. (2010) Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.
J. Biol. Chem., 285 (1): 381-91.
[PMID:19875448]
2. Rajagopal, A; Rao, AU; Amigo, J; Tian, M; Upadhyay, SK; Hall, C; Uhm, S; Mathew, MK; Fleming, MD; Paw, BH; et al.. (2008) Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
Nature, 453 (7198): 1127-31.
[PMID:18418376]
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