Cytochrome P450

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The cytochrome P450 enzyme family (CYP450), E.C. 1.14.-.-, were originally defined by their strong absorbance at 450 nm due to the reduced carbon monoxide-complexed haem component of the cytochromes. They are an extensive family of haem-containing monooxygenases with a huge range of both endogenous and exogenous substrates. Listed below are the human enzymes; their relationship with rodent CYP450 enzyme activities is obscure in that the species orthologue may not mediate metabolism of the same substrates. Although the majority of CYP450 enzyme activities are concentrated in the liver, the extrahepatic enzyme activities also contribute to patho/physiological processes. Genetic variation of CYP450 isoforms is widespread and likely underlies a significant proportion of the individual variation to drug administration.

CYP1 family

Enzymes

CYP1A1 Show summary »

CYP1A2 Show summary »

CYP1B1 Show summary »

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CYP2 family

Enzymes

CYP2A6 Show summary »

CYP2A7 Show summary »

CYP2A13 Show summary »

CYP2B6 Show summary »

CYP2C8 Show summary »

CYP2C9 Show summary »

CYP2C18 Show summary »

CYP2C19 Show summary »

CYP2D6 Show summary »

CYP2E1 Show summary »

CYP2F1 Show summary »

CYP2J2 Show summary »

CYP2R1 Show summary »

CYP2S1 Show summary »

CYP2U1 Show summary »

CYP2W1 Show summary »

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CYP3 family

Enzymes

CYP3A4 Show summary »

CYP3A5 Show summary »

CYP3A7 Show summary »

CYP3A43 Show summary »

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CYP4 family

Enzymes

CYP4A11 Show summary »

CYP4A22 Show summary »

CYP4B1 Show summary »

CYP4F2 Show summary »

CYP4F3 Show summary »

CYP4F8 Show summary »

CYP4F11 Show summary »

CYP4F12 Show summary »

CYP4F22 Show summary »

CYP4V2 Show summary »

CYP4X1 Show summary »

CYP4Z1 Show summary »

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CYP5, CYP7 and CYP8 families

Enzymes

CYP5A1 Show summary »

Prostacyclin synthase (CYP8A1) Show summary »

CYP7A1 Show summary »

CYP7B1 Show summary »

CYP8B1 Show summary »

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CYP11, CYP17, CYP19, CYP20 and CYP21 families

Enzymes

CYP11A1 Show summary » More detailed page

CYP11B1 Show summary » More detailed page

Aldosterone synthase (CYP11B2) Show summary »

CYP17A1 Show summary » More detailed page

Aromatase (CYP19A1) Show summary » More detailed page

CYP20A1 Show summary »

CYP21A2 Show summary »

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CYP24, CYP26 and CYP27 families

Enzymes

CYP24A1 Show summary »

CYP26A1 Show summary »

CYP26B1 Show summary »

CYP26C1 Show summary »

Sterol 27-hydroxylase (CYP27A1) Show summary »

CYP27B1 Show summary »

CYP27C1 Show summary »

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CYP39, CYP46 and CYP51 families

Enzymes

CYP39A1 Show summary »

Cholesterol 24-hydroxylase (CYP46A1) Show summary »

Lanosterol 14-α-demethylase (CYP51A1) Show summary »

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Further reading

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References

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