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Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP1A1
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| Nomenclature |
CYP1A1
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| Other names |
Aryl hydrocarbon hydroxylase,
CP11,
CYP1,
P1-450,
P450-C,
P450DX,
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1,
AHH,
AHRR,
Cyp45c,
Cypc45c,
P-450MC,
P450form6,
CYPIA1,
Cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c),
P450MT2,
cytochrome P1-450,
cytochrome P450 1A1,
cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c),
cytochrome P450, 1a1,
cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c),
cytochrome P450-C,
cytochrome P450MT2,
dioxin-inducible,
flavoprotein-linked monooxygenase,
microsomal monooxygenase,
xenobiotic monooxygenase,
cytochrome P450 subfamily I, polypeptide 1,
P450-1
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| Genes |
CYP1A1 (Hs), Cyp1a1 (Mm), Cyp1a1 (Rn) |
| Ensembl ID |
ENSG00000140465 (Hs), ENSMUSG00000032315 (Mm), ENSRNOG00000019500 (Rn)
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| EC number |
1.14.1.1
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CYP1A2
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| Nomenclature |
CYP1A2
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| Other names |
Phenacetin O-deethylase,
CP12,
P3-450,
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2,
CYPD45,
P-450d,
RATCYPD45,
CYPIA2,
Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d),
Cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d),
P-448,
P450-D,
cytochrome P-448,
cytochrome P-450d,
cytochrome P450 1A2,
cytochrome P450, 1a2,
cytochrome P450-D,
P450-3,
aromatic compound inducible
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| Genes |
CYP1A2 (Hs), Cyp1a2 (Mm), Cyp1a2 (Rn) |
| Ensembl ID |
ENSG00000140505 (Hs), ENSMUSG00000032310 (Mm)
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| EC number |
1.14.1.1
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CYP1B1
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| Nomenclature |
CYP1B1
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| Other names |
CP1B,
GLC3A,
cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile),
CYPIB1,
Cytochrome P450 1b1,
P450RAP,
cytochrome P450, subfamily 1B, polypeptide 1,
cytochrome P450RAP
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| Genes |
CYP1B1 (Hs), Cyp1b1 (Mm), Cyp1b1 (Rn) |
| Ensembl ID |
ENSG00000138061 (Hs), ENSMUSG00000024087 (Mm), ENSRNOG00000040287 (Rn)
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| EC number |
1.14.1.1
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| Comment |
Mutations have been associated with primary congenitial glucoma [11]
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Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP2A6
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| Nomenclature |
CYP2A6
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| Other names |
Coumarin 7-hydroxylase,
CPA6,
CYP2A,
CYP2A3,
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6,
Cyp2a3a,
RATCYP2A3A,
CYPIIA3,
Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3),
cytochrome P450 2A3,
cytochrome P450, family 2, subfamily A, polypeptide 3a,
Cyp15a1,
D7Ucla4,
testosterone 15alpha-hydroxylase
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| Genes |
CYP2A6 (Hs), Cyp2a4 (Mm), Cyp2a3 (Rn) |
| Ensembl ID |
ENSG00000255974 (Hs), ENSMUSG00000074254 (Mm), ENSRNOG00000028900 (Rn)
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| EC number |
1.14.14.1
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| Comment |
Metabolises nicotine
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CYP2A7
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| Nomenclature |
CYP2A7
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| Other names |
Coumarin 7-hydroxylase,
CYPIIA7,
CYP2A,
P450-IIA4,
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7
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| Genes |
CYP2A7 (Hs) |
| Ensembl ID |
ENSG00000198077 (Hs)
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| EC number |
1.14.14.1
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| Comment |
CYP2A7 does not incorporate haem and is functionally inactive [3]
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CYP2A13
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| Nomenclature |
CYP2A13
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| Other names |
CYPIIA13,
CPAD,
CYP2A,
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
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| Genes |
CYP2A13 (Hs) |
| Ensembl ID |
ENSG00000197838 (Hs)
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| EC number |
1.14.14.1
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CYP2B6
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| Nomenclature |
CYP2B6
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| Other names |
Cype,
CYPIIB6,
P450 IIB1,
CYP2B,
CPB6,
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6,
cytochrome P450, family 2, subfamily B,
cytochrome P450, subfamily IIB (phenobarbital-inducible),
CYPIIB2,
Cyp2b2,
Cytochrome P450 subfamily IIB (phenobarbital-inducible)(b e),
Cytochrome P450, family 2, subfamily b, polypeptide 2,
Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e),
cytochrome P-450b type e,
cytochrome P-450e-M,
cytochrome P450 2B2,
cytochrome P450 PB4,
cytochrome P450E,
p16,
phenobarbitol inducible, type b,
Cyp2b20
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| Genes |
CYP2B6 (Hs), Cyp2b10 (Mm), Cyp2b2 (Rn) |
| Ensembl ID |
ENSG00000197408 (Hs), ENSMUSG00000030483 (Mm), ENSRNOG00000020775 (Rn)
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| EC number |
1.14.14.1
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CYP2C8
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| Nomenclature |
CYP2C8
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| Other names |
CYPIIC8,
P450 form 1,
P450 MP-12/MP-20,
P450 IIC2,
S-mephenytoin 4-hydroxylase ,
CPC8,
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8,
Cyp2c65,
Cyp2c65_predicted,
Cyp2c79_predicted,
LOC293985,
cytochrome P450, family 2, subfamily c, polypeptide 65,
cytochrome P450, family 2, subfamily c, polypeptide 65 (predicted),
cytochrome P450, family 2, subfamily c, polypeptide 79,
cytochrome P450, family 2, subfamily c, polypeptide 79 (predicted)
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| Genes |
CYP2C8 (Hs), Cyp2c65 (Mm), Cyp2c79 (Rn) |
| Ensembl ID |
ENSG00000138115 (Hs), ENSMUSG00000067231 (Mm), ENSRNOG00000030661 (Rn)
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| EC number |
1.14.14.1
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CYP2C9
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| Nomenclature |
CYP2C9
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| Other names |
(R)-Limonene 6-monooxygenase,
(S)-limonene 6-monooxygenase,
(S)-limonene 7-monooxygenase,
CYPIIC9,
P450 PB-1,
P450 MP-4/MP-8,
S-mephenytoin 4-hydroxylase,
P-450MP,
CYP2C10,
P450IIC9,
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9
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| Genes |
CYP2C9 (Hs) |
| Ensembl ID |
ENSG00000138109 (Hs)
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| EC number |
1.14.13.80
1.14.13.48
1.14.13.49
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CYP2C18
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| Nomenclature |
CYP2C18
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| Other names |
CYPIIC18,
P450-6B/29C,
CYP2C17,
P450IIC17,
CPCI,
CYP2C,
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18,
Cyp2c55,
Cyp2c55_predicted,
Cyp2c80_predicted,
LOC292330,
CYPIIC24,
CYPIIC55,
P450-PROS2,
cytochrome P450 2C24,
cytochrome P450 2C55,
cytochrome P450, family 2, subfamily c, polypeptide 55,
cytochrome P450, family 2, subfamily c, polypeptide 55 (predicted),
cytochrome P450, family 2, subfamily c, polypeptide 80 (predicted),
cytochrome P450-PROS2
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| Genes |
CYP2C18 (Hs), Cyp2c55 (Mm), Cyp2c80 (Rn) |
| Ensembl ID |
ENSG00000108242 (Hs), ENSMUSG00000025002 (Mm), ENSRNOG00000001466 (Rn)
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| EC number |
1.14.14.1
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CYP2C19
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| Nomenclature |
CYP2C19
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| Other names |
(R)-limonene 6-monooxygenase,
(S)-limonene 6-monooxygenase,
(S)-limonene 7-monooxygenase,
CYPIIC19,
P450-11A,
mephenytoin 4-hydroxylase,
CYPIIC17,
P450-254C,
CYP2C,
P450IIC19,
CPCJ,
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19,
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
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| Genes |
CYP2C19 (Hs), Cyp2c50 (Mm), LOC246070 (Rn) |
| Ensembl ID |
ENSG00000165841 (Hs), ENSMUSG00000054827 (Mm)
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| EC number |
1.14.13.80
1.14.13.48
1.14.13.49
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CYP2D6
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| Nomenclature |
CYP2D6
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| Other names |
Debrisoquine 4-hydroxylase,
CYPIID6,
P450-DB1,
CYP2DL1,
CYP2D7P2,
CYP2D7BP,
CYP2D8P2,
CYP2D7AP,
CPD6,
CYP2D,
P450C2D,
cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6,
cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2,
cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2,
cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2,
cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2,
Cyp2d18,
Cyp2d22,
Cyp2d4,
Cyp2d4v1,
Cyp2d4v2,
Cyp2d6,
Cyp2d6_mapped,
CYPIID18,
CYPIID4,
Cytochrome P450 subfamily IID4,
Cytochrome P450, subfamily IID, polypeptide 6,
Cytochrome P450, subfamily IID4,
P450 2D-29/2D-35,
P450-CMF3,
P450-DB4,
cytochrome P450 2D-29,
cytochrome P450 2D-35,
cytochrome P450 2D18,
cytochrome P450 2D4,
cytochrome P450, family 2, subfamily d, polypeptide 22,
cytochrome P450, family 2, subfamily d, polypeptide 4,
cytochrome P450, subfamily 2D, polypeptide 6,
cytochrome P450, subfamily IID, polypeptide 6 (mapped),
cytochrome P450-CMF3,
cytochrome P450-DB4,
2D22
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| Genes |
CYP2D6 (Hs), Cyp2d22 (Mm), Cyp2d4 (Rn) |
| Ensembl ID |
ENSG00000100197 (Hs), ENSMUSG00000061740 (Mm), ENSRNOG00000032261 (Rn)
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| EC number |
1.14.14.1
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CYP2E1
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| Nomenclature |
CYP2E1
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| Other names |
CYPIIE1,
P450-J,
CYP2E,
cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1,
4-nitrophenol 2-hydroxylase,
Cytochrome P450 subfamily 2e1 (ethanol-inducible),
P450RLM6,
cytochrome P450 2E1,
cytochrome P450, family 2, subfamily e, polypeptide 1,
cytochrome P450, subfamily 2E, polypeptide 1,
cytochrome P450, subfamily 2e1 (ethanol-inducible),
cytochrome P450-J,
cytochrome P450RLM6
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| Genes |
CYP2E1 (Hs), Cyp2e1 (Mm), Cyp2e1 (Rn) |
| Ensembl ID |
ENSG00000130649 (Hs), ENSMUSG00000025479 (Mm), ENSRNOG00000012458 (Rn)
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| EC number |
1.14.14.1
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CYP2F1
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| Nomenclature |
CYP2F1
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| Other names |
CYPIIF1,
CYP2F,
cytochrome P450, subfamily IIF, polypeptide 1,
Cyp2f2,
CYPIIF2,
CYP4502F4,
Cyp2f1,
Cytochrome P450 subfamily IIF polypeptide 1,
P450-NAH-2,
cytochrome P450 2F2,
cytochrome P450, family 2, subfamily f, polypeptide 2,
cytochrome P450, family 2, subfamily f, polypeptide 4,
cytochrome P450, subfamily 2F, polypeptide 1,
cytochrome P450-NAH-2,
naphthalene dehydrogenase,
naphthalene hydroxylase
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| Genes |
CYP2F1 (Hs), Cyp2f2 (Mm), Cyp2f4 (Rn) |
| Ensembl ID |
ENSG00000197446 (Hs), ENSMUSG00000052974 (Mm)
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| EC number |
1.14.14.1
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CYP2J2
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| Nomenclature |
CYP2J2
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| Other names |
Arachidonic acid epoxygenase,
CYPIIJ2,
cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2,
cytochrome P450, family 2, subfamily J, polypeptide 4
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| Genes |
CYP2J2 (Hs), Cyp2j6 (Mm), Cyp2j4 (Rn) |
| Ensembl ID |
ENSG00000134716 (Hs), ENSMUSG00000052914 (Mm), ENSRNOG00000031004 (Rn)
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| EC number |
1.14.14.1
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CYP2R1
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| Nomenclature |
CYP2R1
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| Other names |
Vitamin D 25-hydroxylase,
Cyp2r1_predicted,
LOC361631,
cytochrome P450, family 2, subfamily R, polypeptide 1,
cytochrome P450, family 2, subfamily r, polypeptide 1 (predicted)
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| Genes |
CYP2R1 (Hs), Cyp2r1 (Mm), Cyp2r1 (Rn) |
| Ensembl ID |
ENSG00000186104 (Hs), ENSMUSG00000030670 (Mm), ENSRNOG00000011367 (Rn)
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| EC number |
1.14.13.15
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CYP2S1
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| Nomenclature |
CYP2S1
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| Other names |
CYPIIS1,
cytochrome P450, subfamily IIS, polypeptide 1,
Cyp2s1_predicted,
LOC308445,
cytochrome P450 2S1,
cytochrome P450, family 2, subfamily s, polypeptide 1,
cytochrome P450, family 2, subfamily s, polypeptide 1 (predicted)
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| Genes |
CYP2S1 (Hs), Cyp2s1 (Mm), Cyp2s1 (Rn) |
| Ensembl ID |
ENSG00000167600 (Hs), ENSMUSG00000040703 (Mm), ENSRNOG00000020743 (Rn)
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| EC number |
1.14.14.1
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CYP2U1
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| Nomenclature |
CYP2U1
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| Other names |
Cyp2u1_predicted,
LOC310848,
cytochrome P450 2U1,
cytochrome P450, family 2, subfamily u, polypeptide 1,
cytochrome P450, family 2, subfamily u, polypeptide 1 (predicted)
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| Genes |
CYP2U1 (Hs), Cyp2u1 (Mm), Cyp2u1 (Rn) |
| Ensembl ID |
ENSG00000155016 (Hs), ENSMUSG00000027983 (Mm), ENSRNOG00000011053 (Rn)
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| EC number |
1.14.14.1
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CYP2W1
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| Nomenclature |
CYP2W1
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| Other names |
CYPIIW1,
FLJ20359,
MGC34287,
Cyp2w1_predicted,
LOC288517,
cytochrome P450, family 2, subfamily W, polypeptide 1,
cytochrome P450, family 2, subfamily W, polypeptide 1 (predicted)
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| Genes |
CYP2W1 (Hs), Cyp2w1 (Mm), Cyp2w1 (Rn) |
| Ensembl ID |
ENSG00000073067 (Hs), ENSMUSG00000029541 (Mm), ENSRNOG00000022355 (Rn)
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| EC number |
1.14.14.-
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Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP3A4
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| Nomenclature |
CYP3A4
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| Other names |
Quinine 3-monooxygenase,
CYPIIIA4,
Nifedipine oxidase,
CYP4503A3,
CYPIIIA3,
HLp,
taurochenodeoxycholate 6-α-hydroxylase,
NF-25,
P450-PCN1,
albendazole monooxygenase,
albendazole sulfoxidase,
CYP3A3,
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4,
Cyp3a11,
Cyp3a2,
MGC108545,
CYPIIIA2,
P450-PCN2,
P450/6-beta-A,
cytochrome P450 3A2,
cytochrome P450, family 3, subfamily a, polypeptide 11,
cytochrome P450, family 3, subfamily a, polypeptide 2,
cytochrome P450-PCN2,
cytochrome P450/6-beta-A,
testosterone 6-beta-hydroxylase,
steroid inducible,
Cyp3a41
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| Genes |
CYP3A4 (Hs), Cyp3a41a (Mm), Cyp3a2 (Rn) |
| Ensembl ID |
ENSG00000160868 (Hs), ENSMUSG00000075551 (Mm), ENSRNOG00000000978 (Rn)
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| EC number |
1.14.13.67
1.14.13.97
1.14.13.32
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| Comment |
Metabolises a vast range of xenobiotics, including antidepressants, benzodiazepines, calcium channel blockers, and chemotherapeutic agents
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CYP3A5
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| Nomenclature |
CYP3A5
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| Other names |
CYPIIIA5,
P450-PCN3,
HLp2,
PCN3,
P450PCN3,
CP35,
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5,
Cyp3a13,
Cyp3a9,
MGC93139,
P450olf3,
3AH15,
CYPIIIA9,
P450-OLF3,
cytochrome P450 3A9,
cytochrome P450 olfactive 3,
cytochrome P450, family 3, subfamily a, polypeptide 13,
cytochrome P450, family 3, subfamily a, polypeptide 9,
cytochrome P450-OLF3,
olfactive,
olfactory cytochrome P450olf3
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| Genes |
CYP3A5 (Hs), Cyp3a9 (Rn) |
| Ensembl ID |
ENSG00000106258 (Hs), ENSRNOG00000001379 (Rn)
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| EC number |
1.14.14.1
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CYP3A7
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CYP3A43
Show »« Hide
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Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP4A11
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| Nomenclature |
CYP4A11
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| Other names |
CYPIVA11,
lauric acid ω-hydroxylase,
fatty acid ω-hydroxylase,
P-450 HK ω,
CYP4AII,
20-hydroxyeicosatetraenoic acid synthase,
20-HETE synthase,
P450-HL-ω,
CYP4A2,
cytochrome P450, subfamily IVA, polypeptide 11,
CYPIVA10,
Cyp4a1,
Cyp4a10,
Cyp4a22,
MGC108515,
Cytochrome P450 IVA1,
Cytochrome P450, IVA1,
P450-LA-omega 1,
P452,
cytochrome P450 4A10,
cytochrome P450, 4A1,
cytochrome P450, 4a10,
cytochrome P450, family 4, subfamily A, polypeptide 22,
cytochrome P450, family 4, subfamily a, polypeptide 1,
cytochrome P450, family 4, subfamily a, polypeptide 10,
cytochrome P450-LA-omega 1,
cytochrome P452,
lauric acid omega-hydroxylase,
RP1,
Cyp4a,
D4Rp1
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| Genes |
CYP4A11 (Hs), Cyp4a10 (Mm), Cyp4a1 (Rn) |
| Ensembl ID |
ENSG00000187048 (Hs), ENSMUSG00000066072 (Mm), ENSRNOG00000009597 (Rn)
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| EC number |
1.14.15.3
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CYP4A22
Show »« Hide
| Nomenclature |
CYP4A22
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| Other names |
CYPIVA22,
lauric acid ω-hydroxylase,
fatty acid ω-hydroxylase,
Cyp4a12,
MGC93354,
CYPIVA12,
CYPIVA8,
P450-KP1,
P450-PP1,
cytochrome P450 4A12,
cytochrome P450, 4a12,
cytochrome P450, family 4, subfamily a, polypeptide 8,
cytochrome P450-KP1,
cytochrome P450-PP1
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| Genes |
CYP4A22 (Hs), Cyp4a12b (Mm), Cyp4a8 (Rn) |
| Ensembl ID |
ENSG00000162365 (Hs), ENSMUSG00000078597 (Mm), ENSRNOG00000008842 (Rn)
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| EC number |
1.14.15.3
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CYP4B1
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| Nomenclature |
CYP4B1
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| Other names |
CYPIVB1,
P450-HP,
cytochrome P450, subfamily IVB, polypeptide 1,
Cytochrome P450 subfamily IVB polypeptide 1,
Cytochrome P450 subfamily IVB polypeptide 1 see also D5M4Rp1,
P450 L-2,
P450-isozyme 5,
cytochrome P450 4B1,
cytochrome P450 L-2,
cytochrome P450 isozyme 5,
cytochrome P450, family 4, subfamily b, polypeptide 1,
cytochrome P450, subfamily 4B, polypeptide 1
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| Genes |
CYP4B1 (Hs), Cyp4b1 (Mm), Cyp4b1 (Rn) |
| Ensembl ID |
ENSG00000142973 (Hs), ENSMUSG00000028713 (Mm), ENSRNOG00000009741 (Rn)
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| EC number |
1.14.14.1
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CYP4F2
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| Nomenclature |
CYP4F2
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| Other names |
Leukotriene B4 20-monooxygenase 1,
leukotriene B4 ω-hydroxylase 1,
CYPIVF2,
cytochrome P450-LTB-ω,
cytochrome P450, subfamily IVF, polypeptide 2,
CYPIVF4,
cytochrome P450 4F4,
cytochrome P450, family 4, subfamily f, polypeptide 4
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| Genes |
CYP4F2 (Hs), Cyp4f15 (Mm), Cyp4f4 (Rn) |
| Ensembl ID |
ENSG00000186115 (Hs), ENSMUSG00000073424 (Mm), ENSRNOG00000032895 (Rn)
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| EC number |
1.14.13.30
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| Comment |
Responsible for ω-hydroxylation of LTB4, LXB4 [7], and tocopherols, including vitamin E [10]
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CYP4F3
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| Nomenclature |
CYP4F3
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| Other names |
Leukotriene B4 20-monooxygenase 2,
leukotriene B4 ω-hydroxylase 2,
CYPIVF3,
cytochrome P450-LTB-ω,
LTB4H,
CYP4F,
cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase),
Cyp4f18_predicted,
Cyp4f3,
LOC290623,
MGC124833,
cytochrome P450 4F3,
cytochrome P450, family 4, subfamily f, polypeptide 18,
cytochrome P450, family 4, subfamily f, polypeptide 18 (predicted),
cytochrome P450-LTB-omega,
leukotriene-B(4) 20-monooxygenase 2,
leukotriene-B(4) omega-hydroxylase 2
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| Genes |
CYP4F3 (Hs), Cyp4f18 (Mm), Cyp4f18 (Rn) |
| Ensembl ID |
ENSG00000186529 (Hs), ENSMUSG00000003484 (Mm), ENSRNOG00000015751 (Rn)
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| EC number |
1.14.13.30
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| Comment |
Responsible for ω-hydroxylation of LTB4, LXB4 [7], and polyunsaturated fatty acids [2,6]
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CYP4F8
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| Nomenclature |
CYP4F8
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| Other names |
CYPIVF8,
cytochrome P450, subfamily IVF, polypeptide 8,
Cyp4f17_predicted,
LOC500801,
RGD1561655,
RGD1561655_predicted,
cytochrome P450, family 4, subfamily f, polypeptide 17,
cytochrome P450, family 4, subfamily f, polypeptide 17 (predicted),
similar to Cytochrome P450 4F6 (CYPIVF6),
similar to Cytochrome P450 4F6 (CYPIVF6) (predicted),
EG208285
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| Genes |
CYP4F8 (Hs), Cyp4f17 (Mm), Cyp4f17 (Rn) |
| Ensembl ID |
ENSG00000186526 (Hs), ENSMUSG00000091586 (Mm), ENSRNOG00000042496 (Rn)
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| EC number |
1.14.14.1
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CYP4F11
Show »« Hide
| Nomenclature |
CYP4F11
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| Other names |
CYPIVF11,
cytochrome P450, subfamily IVF, polypeptide 11,
Cyp4f40_predicted,
LOC503122,
RGD1559596,
RGD1559596_predicted,
cytochrome P450, family 4, subfamily f, polypeptide 40,
cytochrome P450, family 4, subfamily f, polypeptide 40 (predicted),
similar to Cyp4f15 protein,
similar to Cyp4f15 protein (predicted),
EG631304
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| Genes |
CYP4F11 (Hs), Cyp4f40 (Mm), Cyp4f40 (Rn) |
| Ensembl ID |
ENSG00000171903 (Hs), ENSMUSG00000090700 (Mm), ENSRNOG00000043344 (Rn)
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| EC number |
1.14.14.1
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CYP4F12
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| Nomenclature |
CYP4F12
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| Other names |
cytochrome P450, subfamily IVF, polypeptide 12,
Cyp4f1,
Cyp4f14,
Cyp4f2,
MGC93476,
CYPIVF1,
P450-A3,
cytochrome P450 4F1,
cytochrome P450, family 4, subfamily F, polypeptide 2,
cytochrome P450, family 4, subfamily f, polypeptide 1,
cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase),
cytochrome P450-A3,
leukotriene B4 omega hydroxylase
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| Genes |
CYP4F12 (Hs), Cyp4f14 (Mm), Cyp4f1 (Rn) |
| Ensembl ID |
ENSG00000186204 (Hs), ENSMUSG00000024292 (Mm), ENSRNOG00000004786 (Rn)
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| EC number |
1.14.14.1
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| Comment |
AC004597.1 (ENSG00000225607) is described as being highly similar to CYP4F12
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CYP4F22
Show »« Hide
| Nomenclature |
CYP4F22
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| Other names |
FLJ39501,
Cyp4f39_predicted,
LOC299566_predicted,
RGD1308796,
RGD1308796_predicted,
cytochrome P450, family 4, subfamily f, polypeptide 39,
cytochrome P450, family 4, subfamily f, polypeptide 39 (predicted),
similar to RIKEN cDNA 4732474A20 gene (predicted)
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| Genes |
CYP4F22 (Hs), Cyp4f39 (Mm), Cyp4f39 (Rn) |
| Ensembl ID |
ENSG00000171954 (Hs), ENSMUSG00000061126 (Mm), ENSRNOG00000029478 (Rn)
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| EC number |
1.14.14.-
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CYP4V2
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CYP4X1
Show »« Hide
| Nomenclature |
CYP4X1
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| Other names |
MGC40051,
CYPIVX1,
cytochrome P450 4X1,
cytochrome P450, family 4, subfamily x, polypeptide 1,
Cyp4a28-ps
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| Genes |
CYP4X1 (Hs), Cyp4x1 (Mm), Cyp4x1 (Rn) |
| Ensembl ID |
ENSG00000186377 (Hs), ENSMUSG00000047155 (Mm), ENSRNOG00000043513 (Rn)
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| EC number |
1.14.14.1
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CYP4Z1
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CYP5, CYP7 and CYP8 families
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP5A1
Show »« Hide
| Nomenclature |
CYP5A1
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| Other names |
Thromboxane synthase,
TXA synthase,
TBXAS1,
CYP5,
THAS,
TS,
TXAS,
TXS,
thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V),
cytochrome P450, family 5, subfamily A, polypeptide 1,
ThromboxA ane synthase 1,
cytochrome P450 5A1,
thromboxane A synthase 1,
thromboxane A synthase 1, platelet,
thromboxane-A synthase
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| Genes |
TBXAS1 (Hs), Tbxas1 (Mm), Tbxas1 (Rn) |
| Ensembl ID |
ENSG00000059377 (Hs), ENSMUSG00000029925 (Mm), ENSRNOG00000007918 (Rn)
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| EC number |
5.3.99.5
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| Comment |
Converts PGH2 to thromboxane A2. Inhibited by dazoxiben [9] and camonagrel [5]
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CYP7A1
Show »« Hide
| Nomenclature |
CYP7A1
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| Other names |
Cholesterol 7-α-monooxygenase,
cholesterol 7-α-hydroxylase,
CYPVII,
CYP7,
cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase), polypeptide 1,
cholesterol 7 alpha-monooxygenase,
CHAP,
CYP7S1,
Cytochrom P450 (cholesterol hydroxylase 7 alpha),
cholesterol 7-alpha hydroxylase,
cholesterol 7-alpha-hydroxylase,
cholesterol 7-alpha-monooxygenase,
cytochrome P450 (cholesterol hydroxylase 7 alpha),
cytochrome P450, 7a1,
cytochrome P450, family 7, subfamily a, polypeptide 1,
cholesterol 7 alpha hydroxylase
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| Genes |
CYP7A1 (Hs), Cyp7a1 (Mm), Cyp7a1 (Rn) |
| Ensembl ID |
ENSG00000167910 (Hs), ENSMUSG00000028240 (Mm), ENSRNOG00000009488 (Rn)
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| EC number |
1.14.13.17
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CYP7B1
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| Nomenclature |
CYP7B1
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| Other names |
Oxysterol 7-α-hydroxylase,
25-hydroxycholesterol 7-α-hydroxylase,
SPG5A,
cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1,
spastic paraplegia 5A (autosomal recessive),
25-hydroxycholesterol 7-alpha-hydroxylase,
Cytochrom P450,
HCT-1,
cytochrome P450 7B1,
cytochrome P450, subfamily 7B, polypeptide 1,
hippocampal transcript 1 protein,
oxysterol 7-alpha-hydroxylase,
D3Ertd552e
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| Genes |
CYP7B1 (Hs), Cyp7b1 (Mm), Cyp7b1 (Rn) |
| Ensembl ID |
ENSG00000172817 (Hs), ENSMUSG00000039519 (Mm), ENSRNOG00000009730 (Rn)
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| EC number |
1.14.13.100
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CYP8A1
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| Nomenclature |
CYP8A1
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| Other names |
Prostaglandin I2 synthase,
PTGIS,
PGIS,
cytochrome P450, family 8, subfamily A, polypeptide 1,
Prostaglandin I2 (prostacyclin) synthase,
prostacyclin synthase,
prostaglandin I2 synthase,
Pgi2
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| Genes |
PTGIS (Hs), Ptgis (Mm), Ptgis (Rn) |
| Ensembl ID |
ENSG00000124212 (Hs), ENSMUSG00000017969 (Mm), ENSRNOG00000008245 (Rn)
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| EC number |
5.3.99.4
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| Comment |
Inhibited by tranylcypromine [4]
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CYP8B1
Show »« Hide
| Nomenclature |
CYP8B1
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| Other names |
7-α-Hydroxycholest-4-en-3-one 12-α-hydroxylase,
CYPVIIIB1,
7-α-hydroxy-4-cholesten-3-one 12-α-hydroxylase,
sterol 12-α-hydroxylase,
CYP12,
cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1,
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase,
cytochrome P450 8b1 sterol 12 alpha-hydrolase,
cytochrome P450, 8b1, sterol 12 alpha-hydrolase,
cytochrome P450, family 8, subfamily b, polypeptide 1,
sterol 12-alpha-hydrolase
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| Genes |
CYP8B1 (Hs), Cyp8b1 (Mm), Cyp8b1 (Rn) |
| Ensembl ID |
ENSG00000180432 (Hs), ENSMUSG00000050445 (Mm), ENSRNOG00000019481 (Rn)
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| EC number |
1.14.13.95
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CYP11, CYP17, CYP19, CYP20 and CYP21 families
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP11A1
Show »« Hide
| Nomenclature |
CYP11A1
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| Other names |
Cholesterol side-chain cleavage enzyme,
cholesterol desmolase,
CYPXIA1,
P450scc,
CYP11A,
P450SCC,
cytochrome P450, subfamily XIA (cholesterol side chain cleavage),
cholesterol monooxygenase (side-chain-cleaving),
P450(scc),
cholesterol side-chain cleavage cytochrome P450,
cholesterol side-chain cleavage enzyme, mitochondrial,
cytochrome P450 subfamily 11A,
cytochrome P450 11A1,
cytochrome P450 11a cholesterol side chain cleavage,
cytochrome P450 side-chain cleavage enzyme,
cytochrome P450 subfamily 11A,
cytochrome P450(scc),
cytochrome P450, subfamily 11A,
cytochrome P450, 11a, cholesterol side,
cytochrome P450, family 11, subfamily a, polypeptide 1,
D9Ertd411e,
cholesterol side chain cleavage,
Scc,
cscc
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| Genes |
CYP11A1 (Hs), Cyp11a1 (Mm), Cyp11a1 (Rn) |
| Ensembl ID |
ENSG00000140459 (Hs), ENSMUSG00000032323 (Mm), ENSRNOG00000008074 (Rn)
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| EC number |
1.14.15.6
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| Comment |
Converts cholesterol to pregnenolone
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CYP11B1
Show »« Hide
| Nomenclature |
CYP11B1
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| Other names |
Steroid 11β-hydroxylase,
CYPXIB1,
P450C11,
P-450c11,
CYP11B,
FHI,
CPN1,
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1,
Cp11ba,
RATCP11BA,
Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase),
P450(11 beta)-DS,
aldosterone synthase,
cytochrome P450 11B1, mitochondrial,
cytochrome P450(11 beta)-DS,
cytochrome P450, subfamily 11B, polypeptide 1,
cytochrome P450C11,
steroid 11-beta-hydroxylase,
Cyp11b-1
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| Genes |
CYP11B1 (Hs), Cyp11b1 (Mm), Cyp11b1 (Rn) |
| Ensembl ID |
ENSG00000160882 (Hs), ENSMUSG00000075604 (Mm), ENSRNOG00000032450 (Rn)
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| EC number |
1.14.15.4
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| Comment |
Converts deoxycortisone and 11-deoxycortisol to cortisone and cortisol, respectively. Loss-of-function mutations are associated with familial adrenal hyperplasia and hypertension. Inhibited by metyrapone [12]
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CYP11B2
Show »« Hide
| Nomenclature |
CYP11B2
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| Other names |
Aldosterone synthase,
ALDOS,
CYPXIB2,
P-450Aldo,
aldosterone-synthesizing enzyme,
steroid 18-hydroxylase,
P-450C18,
CYP11B,
CYP11BL,
CPN2,
P450aldo,
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2,
steroid 11-beta-hydroxylase,
Cp45as,
Cyp11b3,
RNCP45AS,
CYPXIB3,
Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase),
Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase),
P450-Aldo-1,
P450-Aldo-2,
cytochrome P450 11B2, mitochondrial,
cytochrome P450 11B3, mitochondrial,
cytochrome P450, family 11, subfamily B, polypeptide 2,
cytochrome P450, subfamily 11B, polypeptide 2,
cytochrome P450-Aldo-1,
cytochrome P450-Aldo-2,
Cyp11b-2,
steroid-11-beta-hydroxylase
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| Genes |
CYP11B2 (Hs), Cyp11b2 (Mm), Cyp11b2 (Rn) |
| Ensembl ID |
ENSG00000179142 (Hs), ENSMUSG00000022589 (Mm), ENSRNOG00000030111 (Rn)
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| EC number |
1.14.15.4
1.14.15.5
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| Comment |
Converts corticosterone to aldosterone
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CYP17A1
Show »« Hide
| Nomenclature |
CYP17A1
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| Other names |
Steroid 17-α-hydroxylase/17,20 lyase,
CYPXVII,
P450-C17,
P450c17,
steroid 17-α-monooxygenase,
CYP17,
CPT7,
S17AH,
cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia,
Steroid 17-alpha-monooxygenase,
Cytochrome P450 subfamily XVII,
Cytochrome P450, subfamily XVII,
P45017alpha,
cytochrome P450 17A1,
cytochrome P450, family 17, subfamily a, polypeptide 1,
cytochrome P450, subfamily 17,
cytochrome P450-C17,
cytochrome P450c17,
steroid 17-alpha-hydroxylase/17,20 lyase,
steroid 17-alpha hydroxylase
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| Genes |
CYP17A1 (Hs), Cyp17a1 (Mm), Cyp17a1 (Rn) |
| Ensembl ID |
ENSG00000148795 (Hs), ENSMUSG00000003555 (Mm), ENSRNOG00000020035 (Rn)
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| EC number |
1.14.99.9
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| Comment |
Converts pregnenolone and progesterone to 17α-hydroxypregnenolone and 17α-hydroxyprogesterone, respectively. Converts 17α-hydroxypregnenolone and 17α-hydroxyprogesterone to dehydroepiandrosterone and androstenedione, respectively. Converts corticosterone to cortisol
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CYP19A1
Show »« Hide
| Nomenclature |
CYP19A1
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| Other names |
Aromatase,
estrogen synthetase,
P-450AROM,
CYPXIX,
CYP19,
ARO,
CPV1,
ARO1,
CYAR,
cytochrome P450, subfamily XIX (aromatization of androgens),
Cyp19a,
p450arom,
Cytochrome P450 19 aromatase,
Cytochrome P450, 19, aromatase,
cytochrome P-450AROM,
cytochrome P450 19A1,
cytochrome P450 19A1-like,
cytochrome P450 family 19 subfamily a,
cytochrome P450, family 19, subfamily a, polypeptide 1,
cytochrome P450, subfamily 19,
estrogen synthase,
Int-5,
Int5,
Ar,
ArKO
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| Genes |
CYP19A1 (Hs), Cyp19a1 (Mm), Cyp19a1 (Rn) |
| Ensembl ID |
ENSG00000137869 (Hs), ENSMUSG00000032274 (Mm), ENSRNOG00000000196 (Rn)
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| EC number |
1.14.14.1
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| Comment |
Converts androstenedione and testosterone to estrone and 17β-estradiol, respectively. Inhibited by anastrazole [8], and letrozole [1]
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CYP20A1
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CYP21A2
Show »« Hide
| Nomenclature |
CYP21A2
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| Other names |
Steroid 21-hydroxylase,
cytochrome P450 XXI,
21-Ohase,
P450-C21,
P-450c21,
P450-C21B,
CYP21,
CYP21B,
P450c21B,
CA21H,
CPS1,
CAH1,
cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2,
Steroid 21-monooxygenase,
Cyp21a2ps,
21OHB,
Cyp21-ps1,
Oh21-2,
EG632302
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| Genes |
CYP21A2 (Hs), Cyp21a2-ps (Mm) |
| Ensembl ID |
ENSG00000198457 (Hs), ENSMUSG00000092471 (Mm)
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| EC number |
1.14.99.10
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| Comment |
Converts progesterone and 17α-hydroxyprogesterone to deoxycortisone and 11-deoxycortisol, respectively
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CYP24, CYP26 and CYP27 families
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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CYP24A1
Show »« Hide
| Nomenclature |
CYP24A1
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| Other names |
1,25-Dihydroxyvitamin D3 24-hydroxylase,
vitamin D3 24-hydroxylase,
24-Ohase,
P450-CC24,
CYP24,
CP24,
cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase),
24R-Ohase,
25-hydroxyvitaminD324-hydroxylase,
VITD12,
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial,
25-hydroxyvitamin D3 24-hydroxylase,
Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase),
cytochrome P450 24A1,
cytochrome P450, subfamily 24,
cytochrome P450-CC24,
vitamin D(3) 24-hydroxylase,
25-hydroxyvitamin D-24-hydroxylase
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| Genes |
CYP24A1 (Hs), Cyp24a1 (Mm), Cyp24a1 (Rn) |
| Ensembl ID |
ENSG00000019186 (Hs), ENSMUSG00000038567 (Mm), ENSRNOG00000013062 (Rn)
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| EC number |
1.14.13.126
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CYP26A1
Show »« Hide
| Nomenclature |
CYP26A1
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| Other names |
Retinoic acid-metabolizing cytochrome,
P450 retinoic acid-inactivating 1,
P450RAI,
retinoic acid 4-hydroxylase,
CP26,
CYP26,
P450RAI1,
cytochrome P450, subfamily XXVIA, polypeptide 1,
cytochrome P450, 26, retinoic acid,
cytochrome P450, family 26, subfamily A, polypeptide 1,
retinoic acid hydrolase,
retinoic acid hydroxylase,
P450RA,
RAH
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| Genes |
CYP26A1 (Hs), Cyp26a1 (Mm), Cyp26a1 (Rn) |
| Ensembl ID |
ENSG00000095596 (Hs), ENSMUSG00000024987 (Mm), ENSRNOG00000016750 (Rn)
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| EC number |
1.14.-.-
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| Comment |
Inhibited by liarozole
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CYP26B1
Show »« Hide
| Nomenclature |
CYP26B1
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| Other names |
Retinoic acid-metabolizing cytochrome,
P450 retinoic acid-inactivating 2,
P450RAI-2,
P450 26A2,
cytochrome P450 26B1,
cytochrome P450, family 26, subfamily b, polypeptide 1,
CP26,
retinoic acid B1
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| Genes |
CYP26B1 (Hs), Cyp26b1 (Mm), Cyp26b1 (Rn) |
| Ensembl ID |
ENSG00000003137 (Hs), ENSMUSG00000063415 (Mm), ENSRNOG00000015076 (Rn)
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| EC number |
1.14.-.-
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CYP26C1
Show »« Hide
| Nomenclature |
CYP26C1
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| Other names |
Cyp26c1_predicted,
LOC308190,
cytochrome P450, family 26, subfamily C, polypeptide 1,
cytochrome P450, family 26, subfamily C, polypeptide 1 (predicted),
EG546726
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| Genes |
CYP26C1 (Hs), Cyp26c1 (Mm), Cyp26c1 (Rn) |
| Ensembl ID |
ENSG00000187553 (Hs), ENSMUSG00000062432 (Mm), ENSRNOG00000030698 (Rn)
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| EC number |
1.14.-.-
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CYP27A1
Show »« Hide
| Nomenclature |
CYP27A1
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| Other names |
Sterol 26-hydroxylase,
cytochrome P-450C27/25,
sterol 27-hydroxylase,
vitamin D3 25-hydroxylase,
5-β-cholestane-3-α,7-α,12-α-triol 27-hydroxylase,
CYP27,
CTX,
CP27,
cerebrotendinous xanthomatosis,
cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1,
P450C27,
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase,
cytochrome P450 27,
cytochrome P450, family 27, subfamily a, polypeptide 1,
sterol 26-hydroxylase, mitochondrial,
vitamin D(3) 25-hydroxylase,
cholesterol 27 hydroxylase
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| Genes |
CYP27A1 (Hs), Cyp27a1 (Mm), Cyp27a1 (Rn) |
| Ensembl ID |
ENSG00000135929 (Hs), ENSMUSG00000026170 (Mm), ENSRNOG00000017188 (Rn)
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| EC number |
1.14.13.15
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CYP27B1
Show »« Hide
| Nomenclature |
CYP27B1
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| Other names |
25-hydroxyvitamin D-1 α hydroxylase,
cytochrome P450 subfamily XXVIIB polypeptide 1,
calcidiol 1-monooxygenase,
25-OHD-1 α-hydroxylase,
25-hydroxyvitamin D3 1-α-hydroxylase,
VD3 1A hydroxylase,
P450C1 α,
P450VD1-α,
VDD1,
PDDR,
CYP1,
P450c1,
cytochrome P450, subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase), polypeptide 1,
VDDR I,
1alpha(OH)ase,
25-Hydroxyvitamin D3 1alpha-hydroxylase,
Cyp40,
25-OHD-1 alpha-hydroxylase,
25-hydroxyvitamin D(3) 1-alpha-hydroxylase,
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial,
P450C1 alpha,
P450VD1-alpha,
cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase),
cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1,
cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase),
cytochrome P450, family 27, subfamily b, polypeptide 1,
cytochrome P450, subfamily 27b, polypeptide 1,
cytochrome P450C1 alpha,
cytochrome P450VD1-alpha,
cytochrome p450 27B1,
P450VD1alpha,
25(OH)D 1alpha-hydroxylase,
Cp2b,
Vddr,
Cyp27b,
VddrI
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| Genes |
CYP27B1 (Hs), Cyp27b1 (Mm), Cyp27b1 (Rn) |
| Ensembl ID |
ENSG00000111012 (Hs), ENSMUSG00000006724 (Mm)
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| EC number |
1.14.13.13
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CYP27C1
Show »« Hide
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CYP39, CYP46 and CYP51 families
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Cipollone, F; Cicolini, G; Bucci, M. (2008) Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.
Pharmacol. Ther., 118 (2): 161-80.
[PMID:18420277]
Fleming, I. (2008) Vascular cytochrome p450 enzymes: physiology and pathophysiology.
Trends Cardiovasc. Med., 18 (1): 20-5.
[PMID:18206805]
Haining, RL; Nichols-Haining, M. (2007) Cytochrome P450-catalyzed pathways in human brain: metabolism meets pharmacology or old drugs with new mechanism of action?.
Pharmacol. Ther., 113 (3): 537-45.
[PMID:17270273]
Hisaka, A; Ohno, Y; Yamamoto, T; Suzuki, H. (2010) Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450 activity using in vivo information.
Pharmacol. Ther., 125 (2): 230-48.
[PMID:19951720]
Ingelman-Sundberg, M; Sim, SC; Gomez, A; Rodriguez-Antona, C. (2007) Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects.
Pharmacol. Ther., 116 (3): 496-526.
[PMID:18001838]
Johnson, WW. (2008) Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance.
Drug Metab. Rev., 40 (1): 101-47.
[PMID:18259986]
Johnston, JB; Ouellet, H; Podust, LM; Ortiz de Montellano, PR. (2011) Structural control of cytochrome P450-catalyzed ω-hydroxylation.
Arch. Biochem. Biophys., 507 (1): 86-94.
[PMID:20727847]
Kirchheiner, J; Seeringer, A. (2007) Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes.
Biochim. Biophys. Acta, 1770 (3): 489-94.
[PMID:17113714]
Laursen, T; Jensen, K; Møller, BL. (2011) Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450.
Biochim. Biophys. Acta, 1814 (1): 132-8.
[PMID:20624491]
Omura, T. (2010) Structural diversity of cytochrome P450 enzyme system.
J. Biochem., 147 (3): 297-306.
[PMID:20068028]
Ortiz de Montellano, PR. (2010) Hydrocarbon hydroxylation by cytochrome P450 enzymes.
Chem. Rev., 110 (2): 932-48.
[PMID:19769330]
Pelkonen, O; Turpeinen, M; Hakkola, J; Honkakoski, P; Hukkanen, J; Raunio, H. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status.
Arch. Toxicol., 82 (10): 667-715.
[PMID:18618097]
Rezen, T; Contreras, JA; Rozman, D. (2007) Functional genomics approaches to studies of the cytochrome p450 superfamily.
Drug Metab. Rev., 39 (2-3): 389-99.
[PMID:17786628]
Schuster, I. (2011) Cytochromes P450 are essential players in the vitamin D signaling system.
Biochim. Biophys. Acta, 1814 (1): 186-99.
[PMID:20619365]
Shaik, S; Cohen, S; Wang, Y; Chen, H; Kumar, D; Thiel, W. (2010) P450 enzymes: their structure, reactivity, and selectivity-modeled by QM/MM calculations.
Chem. Rev., 110 (2): 949-1017.
[PMID:19813749]
Wijnen, PA; Op den Buijsch, RA; Drent, M; Kuijpers, PM; Kuipers, PM; Neef, C; Bast, A; Bekers, O; Koek, GH. (2007) Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms.
Aliment. Pharmacol. Ther., 26 Suppl 2: 211-9.
[PMID:18081664]
Zanger, UM; Turpeinen, M; Klein, K; Schwab, M. (2008) Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation.
Anal Bioanal Chem, 392 (6): 1093-108.
[PMID:18695978]
1. Bhatnagar, AS; Häusler, A; Schieweck, K; Lang, M; Bowman, R. (1990) Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.
J. Steroid Biochem. Mol. Biol., 37 (6): 1021-7.
[PMID:2149502]
2. Fer, M; Corcos, L; Dréano, Y; Plée-Gautier, E; Salaün, JP; Berthou, F; Amet, Y. (2008) Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.
J. Lipid Res., 49 (11): 2379-89.
[PMID:18577768]
3. Fukami, T; Nakajima, M; Sakai, H; McLeod, HL; Yokoi, T. (2006) CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.
Pharmacogenomics J., 6 (6): 401-12.
[PMID:16636685]
4. Gryglewski, RJ; Bunting, S; Moncada, S; Flower, RJ; Vane, JR. (1976) Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.
Prostaglandins, 12 (5): 685-713.
[PMID:824685]
5. Gryglewski, RJ; Szczeklik, A; Korbut, R; Swies, J; Musiał, J; Krzanowski, M; Maga, P. (1995) The mechanism of anti-thrombotic, thrombolytic and fibrinolytic actions of camonagrel--a new thromboxane synthase inhibitor.
Wien. Klin. Wochenschr., 107 (9): 283-9.
[PMID:7778318]
6. Harmon, SD; Fang, X; Kaduce, TL; Hu, S; Raj Gopal, V; Falck, JR; Spector, AA. (2006) Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.
Prostaglandins Leukot. Essent. Fatty Acids, 75 (3): 169-77.
[PMID:16820285]
7. Mizukami, Y; Sumimoto, H; Isobe, R; Minakami, S. (1993) Omega-hydroxylation of lipoxin B4 by human neutrophil microsomes: identification of omega-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 omega-hydroxylase (cytochrome P-450LTB omega).
Biochim. Biophys. Acta, 1168 (1): 87-93.
[PMID:8389204]
8. Plourde, PV; Dyroff, M; Dukes, M. (1994) Arimidex: a potent and selective fourth-generation aromatase inhibitor.
Breast Cancer Res. Treat., 30 (1): 103-11.
[PMID:7949201]
9. Randall, MJ; Parry, MJ; Hawkeswood, E; Cross, PE; Dickinson, RP. (1981) UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity.
Thromb. Res., 23 (1-2): 145-62.
[PMID:6795753]
10. Sontag, TJ; Parker, RS. (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status.
J. Biol. Chem., 277 (28): 25290-6.
[PMID:11997390]
11. Stoilov, I; Akarsu, AN; Sarfarazi, M. (1997) Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21.
Hum. Mol. Genet., 6 (4): 641-7.
[PMID:9097971]
12. Watanuki, M; Tilley, BE; Hall, PF. (1978) Cytochrome P-450 for 11beta- and 18-hydroxylase activities of bovine adrenocortical mitochondria: one enzyme or two?.
Biochemistry, 17 (1): 127-30.
[PMID:412519]
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