Adenylyl cyclases (ACs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-bound adenylyl cyclases are typically made up of two clusters of six TM domains separating two intracellular, overlapping catalytic domains that are the target for the nonselective activators forskolin, NKH477 (except AC9, [19]) and Gαs (the stimulatory G protein α subunit). Adenosine and its derivatives (e.g. 2',5'-dideoxyadenosine), acting through the P-site, appear to be physiological inhibitors of adenylyl cyclase activity [25]. Three families of adenylyl cyclase are distinguishable: calmodulin (CALM2, CALM3, CALM1, P62158)-stimulated (AC1, AC3 and AC8), Ca2+-inhibitable (AC5, AC6 and AC9) and Ca2+-insensitive (AC2, AC4 and AC7) forms.

Enzymes

AC1 (adenylate cyclase 1) Show summary »

AC2 (adenylate cyclase 2 (brain) ) Show summary »

AC3 (adenylate cyclase 3) Show summary »

AC4 (adenylate cyclase 4) Show summary »

AC5 (adenylate cyclase 5) Show summary »

AC6 (adenylate cyclase 6) Show summary »

AC7 (adenylate cyclase 7) Show summary »

AC8 (adenylate cyclase 8) Show summary »

AC9 (adenylate cyclase 9) Show summary »

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References

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How to cite this family page

Database page citation:

Adenylyl cyclases (ACs). Accessed on 25/08/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=257.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.