Guanylyl cyclases (GCs) C

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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase (GTP diphosphate-lyase (cyclising)), E.C. 4.6.1.2, is a heterodimer comprising a β1 subunit and one of two alpha subunits (α1, α2) giving rise to two functionally indistinguishable isoforms, GC-1 (α1β1) and GC-2 (α2β1) [2-3]. A haem group is associated with the β subunit and is the target for the endogenous ligand NO, and, potentially, carbon monoxide [1]. The enzyme converts guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

The mammalian genome encodes seven transmembrane guanylyl cyclases, GC-A to GC-G, that are homodimeric receptors activated by a diverse range of endogenous ligands. These enzymes also convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adrian Hobbs, Scott Waldman, Annie Beuve, Peter Brouckaert, John C. Burnett, Andreas Friebe, John Garthwaite, Doris Koesling, Michaela Kuhn, Lincoln Potter, Harald Schmidt. Guanylyl cyclases (GCs). Accessed on 24/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=258.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.