CYP39, CYP46 and CYP51 families | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

CYP39, CYP46 and CYP51 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Enzymes

CYP39A1 C Show summary »« Hide summary

Target Id

1372

Nomenclature

CYP39A1

Previous and unofficial names

24-hydroxycholesterol 7-alpha-hydroxylase | oxysterol 7-alpha-hydroxylase | cytochrome P450, family 39, subfamily A, polypeptide 1 | cytochrome P450

Genes

CYP39A1 (Hs), Cyp39a1 (Mm), Cyp39a1 (Rn)

Ensembl ID

ENSG00000146233 (Hs), ENSMUSG00000023963 (Mm), ENSRNOG00000010519 (Rn)

UniProtKB AC

Q9NYL5 (Hs), Q9JKJ9 (Mm)

EC number

1.14.13.99

Comment

Converts 24-hydroxycholesterol to 7α,24-dihydroxycholesterol [1].

Cholesterol 24-hydroxylase (CYP46A1) C Show summary »« Hide summary

Lanosterol 14-α-demethylase (CYP51A1) C Show summary »« Hide summary

Target Id

1374

Nomenclature

CYP51A1

Common abbreviation

Lanosterol 14-α-demethylase

Previous and unofficial names

lanosterol 14-alpha demethylase | sterol 14-alpha demethylase | Cytochrom P450 Lanosterol 14 alpha-demethylase | cytochrome P450, family 51, subfamily A, polypeptide 1 | cytochrome P450

Genes

CYP51A1 (Hs), Cyp51 (Mm), Cyp51 (Rn)

Ensembl ID

ENSG00000001630 (Hs), ENSMUSG00000001467 (Mm), ENSRNOG00000007234 (Rn)

UniProtKB AC

Q16850 (Hs), Q8K0C4 (Mm), Q64654 (Rn)

Inhibitors

azalanstat pK_i 9.1 [2]

Comment

Converts lanosterol to 4,4-dimethylcholesta-8.14.24-trienol.

References

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How to cite this family page

Database page citation:

CYP39, CYP46 and CYP51 families. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=268.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.