Haem oxygenase (heme,hydrogen-donor:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)), E.C. 1.14.99.3, converts heme into biliverdin and carbon monoxide, utilizing NADPH as cofactor.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Enzymes 
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Abraham, NG; Kappas, A. (2008) Pharmacological and clinical aspects of heme oxygenase. Pharmacol. Rev., 60 (1): 79-127. [PMID:18323402]
Bilban, M; Haschemi, A; Wegiel, B; Chin, BY; Wagner, O; Otterbein, LE. (2008) Heme oxygenase and carbon monoxide initiate homeostatic signaling. J. Mol. Med., 86 (3): 267-79. [PMID:18034222]
Chan, KH; Ng, MK; Stocker, R. (2011) Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential. Clin. Sci., 120 (12): 493-504. [PMID:21355854]
Dulak, J; Deshane, J; Jozkowicz, A; Agarwal, A. (2008) Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation, 117 (2): 231-41. [PMID:18195184]
Gozzelino, R; Jeney, V; Soares, MP. (2010) Mechanisms of cell protection by heme oxygenase-1. Annu. Rev. Pharmacol. Toxicol., 50: 323-54. [PMID:20055707]
Kim, HP; Pae, HO; Back, SH; Chung, SW; Woo, JM; Son, Y; Chung, HT. (2011) Heme oxygenase-1 comes back to endoplasmic reticulum. Biochem. Biophys. Res. Commun., 404 (1): 1-5. [PMID:21094129]
Larsen, K; Cheng, C; Duckers, HJ. (2010) Regulation of vulnerable plaque development by the heme oxygenase/carbon monoxide system. Trends Cardiovasc. Med., 20 (2): 58-65. [PMID:20656217]
Paine, A; Eiz-Vesper, B; Blasczyk, R; Immenschuh, S. (2010) Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem. Pharmacol., 80 (12): 1895-903. [PMID:20643109]
Soares, MP; Marguti, I; Cunha, A; Larsen, R. (2009) Immunoregulatory effects of HO-1: how does it work?. Curr Opin Pharmacol, 9 (4): 482-9. [PMID:19586801]
Syapin, PJ. (2008) Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br. J. Pharmacol., 155 (5): 623-40. [PMID:18794892]
Zhu, Y; Silverman, RB. (2008) Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s). Biochemistry, 47 (8): 2231-43. [PMID:18237198]
1. Drummond, GS; Kappas, A. (1981) Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc. Natl. Acad. Sci. U.S.A., 78 (10): 6466-70. [PMID:6947237]
2. Hayashi, S; Omata, Y; Sakamoto, H; Higashimoto, Y; Hara, T; Sagara, Y; Noguchi, M. (2004) Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene. Gene, 336 (2): 241-50. [PMID:15246535]
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The existence of a third non-catalytic version of haem oxygenase, HO3, has been proposed, although this has been suggested to be a pseudogene [2]. The chemical tin protoporphyrin IX acts as a haem oxygenase inhibitor in rat liver with an IC50 value of 11 nM [1].